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| 1. |  | SOARES, S. M.; DOMINGUES, R.; GASPAR, E. B.; SANTOS, P. A. dos; CANUTO, K. M.; MINHO, A. P.; VIEIRA, M. I. B. In vitro ovicidal effect of a Senecio brasiliensis extract and its fractions on Haemonchus contortus. BMC Veterinary Research, v. 15, n. 99, 25 Mar. 2019. 9 p.| Biblioteca(s): Embrapa Agroindústria Tropical; Embrapa Pecuária Sudeste; Embrapa Pecuária Sul. |
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Registro Completo
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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Pecuária Sudeste; Embrapa Pecuária Sul. |
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Data corrente: |
09/05/2019 |
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Data da última atualização: |
17/02/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SOARES, S. M.; DOMINGUES, R.; GASPAR, E. B.; SANTOS, P. A. dos; CANUTO, K. M.; MINHO, A. P.; VIEIRA, M. I. B. |
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Afiliação: |
SUELEN MENDONÇA SOARES, UPF; ROBERT DOMINGUES, CPPSUL; EMANUELLE BALDO GASPAR, CPPSUL; PATRÍCIO AZEVEDO DOS SANTOS, URCAMP; KIRLEY MARQUES CANUTO, CNPAT; ALESSANDRO PELEGRINE MINHO, CPPSE; MARIA ISABEL BOTELHO VIEIRA, UPF. |
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Título: |
In vitro ovicidal effect of a Senecio brasiliensis extract and its fractions on Haemonchus contortus. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
BMC Veterinary Research, v. 15, n. 99, 25 Mar. 2019. |
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Páginas: |
9 p. |
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DOI: |
10.1186/s12917-019-1843-7 |
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Idioma: |
Inglês |
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Conteúdo: |
Background: Haemonchosis affects sheep husbandry and its treatment is often compromised due to the
development of anthelminthic resistance. Plant-derived bioactive compounds have been studied as alternative to
control Haemonchus contortus. The objective of this study was to evaluate the effect of Senecio brasiliensis extracts
on H. contortus egg hatching and infective larvae migration.
Results: The aqueous extract from dried and fresh plant and alkaloid-enriched fraction of the previously dried
leaves of S. brasiliensis inhibited H. contortus egg hatching. The main plant compound in alkaloid fraction was
integerrimine, a pyrrolizidine alkaloid (PA). However, the aqueous extract from dried plant displayed higher efficacy
when compared to their alkaloid enriched or non-polar fractions, meaning that, although PAs contributed to the
ovicidal effect, other compounds in the plant can also contribute to their effect. Furthermore, the aqueous extract
from dried plant also had higher efficacy than aqueous extract from fresh plant in larvae migration inhibition.
Finally, extract from dried plant presented low in vitro cytotoxic effect.
Conclusion: Taken together our results suggest a good anthelmintic effect of S. brasiliensis, especially
when aqueous extract is prepared from dried plant. Further in vivo studies should be performed focused on forms
of administration of this extract in rearing sheep. |
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Palavras-Chave: |
Alcalóides de pirrolizidina; Antelmíntico; Egg hatching; Incubação de ovos; Infective larvae migration; Migração de larvas infectantes; Pequenos ruminantes. |
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Thesagro: |
Anti-Helmíntico; Extrato Vegetal; Incubação Artificial; Maria Mole; Nematóide; Planta Tóxica. |
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Thesaurus NAL: |
Plant extracts; Pyrrolizidine alkaloids; Small ruminants. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/197181/1/In-vitro-ovicidal-effect-Senecio.pdf
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/208998/1/ART19126.pdf
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Marc: |
LEADER 02626naa a2200409 a 4500
001 2108906
005 2020-02-17
008 2019 bl uuuu u00u1 u #d
024 7 $a10.1186/s12917-019-1843-7$2DOI
100 1 $aSOARES, S. M.
245 $aIn vitro ovicidal effect of a Senecio brasiliensis extract and its fractions on Haemonchus contortus.$h[electronic resource]
260 $c2019
300 $a9 p.
520 $aBackground: Haemonchosis affects sheep husbandry and its treatment is often compromised due to the development of anthelminthic resistance. Plant-derived bioactive compounds have been studied as alternative to control Haemonchus contortus. The objective of this study was to evaluate the effect of Senecio brasiliensis extracts on H. contortus egg hatching and infective larvae migration. Results: The aqueous extract from dried and fresh plant and alkaloid-enriched fraction of the previously dried leaves of S. brasiliensis inhibited H. contortus egg hatching. The main plant compound in alkaloid fraction was integerrimine, a pyrrolizidine alkaloid (PA). However, the aqueous extract from dried plant displayed higher efficacy when compared to their alkaloid enriched or non-polar fractions, meaning that, although PAs contributed to the ovicidal effect, other compounds in the plant can also contribute to their effect. Furthermore, the aqueous extract from dried plant also had higher efficacy than aqueous extract from fresh plant in larvae migration inhibition. Finally, extract from dried plant presented low in vitro cytotoxic effect. Conclusion: Taken together our results suggest a good anthelmintic effect of S. brasiliensis, especially when aqueous extract is prepared from dried plant. Further in vivo studies should be performed focused on forms of administration of this extract in rearing sheep.
650 $aPlant extracts
650 $aPyrrolizidine alkaloids
650 $aSmall ruminants
650 $aAnti-Helmíntico
650 $aExtrato Vegetal
650 $aIncubação Artificial
650 $aMaria Mole
650 $aNematóide
650 $aPlanta Tóxica
653 $aAlcalóides de pirrolizidina
653 $aAntelmíntico
653 $aEgg hatching
653 $aIncubação de ovos
653 $aInfective larvae migration
653 $aMigração de larvas infectantes
653 $aPequenos ruminantes
700 1 $aDOMINGUES, R.
700 1 $aGASPAR, E. B.
700 1 $aSANTOS, P. A. dos
700 1 $aCANUTO, K. M.
700 1 $aMINHO, A. P.
700 1 $aVIEIRA, M. I. B.
773 $tBMC Veterinary Research$gv. 15, n. 99, 25 Mar. 2019.
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Embrapa Pecuária Sul (CPPSUL) |
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