Data/hora: 19/04/2024 11:54:56

Biblioteca(s): 	Embrapa Caprinos e Ovinos.	
Data corrente: 	28/01/2015	
Data da última atualização: 	23/09/2019	
Autoria: 	BRESSANI, F. A.; TIZIOTO, P. C.; GIGLIOTI, R.; MEIRELLHES, S. L. C.; COUTINHO, L. L.; BENVENUTI, C. L.; MALAGO JUNIOR, W.; MUDADU, M. de A.; VIEIRA, L. da S.; ZAROS, L. G.; CARRILHO, E.; REGITANO, L. C. de A.	
Afiliação: 	FLAVIA ALINE BRESSANI DONATONI, CPPSE; Pós-graduação - Universidade Federal de São Carlos (UFSCAR) - São Carlos, SP, Brasil; Universidade Estadual Paulista (Unesp) - Jaboticabal, SP, Brasil; Universidade Federal de Lavras, Lavras, MG, Brasil.; Universidade Federal do Rio Grande do Norte (UFRN) - Natal, RN, Brasil; UFRN - Natal, RN, Brasil; WILSON MALAGO JUNIOR, CPPSE; MAURICIO DE ALVARENGA MUDADU, CPPSE; LUIZ DA SILVA VIEIRA, CNPC; UFRN - Natal, RN, Brasil; Universidade de São Paulo - São Carlos, SP, Brasil.; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.	
Título: 	Single nucleotide polymorphisms in candidate genes associated with gastrointestinal nematode infection in goats.	
Ano de publicação: 	2014	
Fonte/Imprenta: 	Genetics and Molecular Research, v. 13, n. 4, p. 8530-8436, Oct. 2014.	
DOI: 	10.4238/2014.October.20.29	
Idioma: 	Inglês	
Conteúdo: 	Abstract: Cytokines are small cell-signaling proteins that play an important role in the immune system, participating in intracellular communication. Four candidate genes of the cytokine family (IL2, IL4, IL13, and IFNG) were selected to identify Single Nucleotide Polymorphisms (SNPs) that might be associated with resistance to gastrointestinal endoparasites in goats. A population of 229 goats, F2 offspring from an F1 intercross was produced by crossing pure Saanen goats, considered as susceptible to gastrointestinal endoparasites, with pure Anglo-Nubian goats, considered resistant. Blood was collected for DNA extraction and fecal samples were also collected for parasite egg count. Polymorphisms were prospected by sequencing animals with extreme phenotype for fecal egg count (FEC) distribution. The association between SNPs and phenotype was determined by using the Fisher exact test with correction for multiple tests. Three of the 10 SNPs were identified as significant (P ? 0.03). They were found in intron 1 of IL2 (ENSBTA00000020883), intron 3 of IL13 (ENSBTA00000015953) and exon 3 of IFNG (ENSBTA00000012529), suggesting an association between them and gastrointestinal endoparasite resistance. Further studies will help describe the effects of these markers accurately before implementing them in marker assisted selection. This study is the pioneer in describing such associations in goats.	
Palavras-Chave: 	Candidate gene; Citocina; Gastrointestinal diseases; Nematode; Nematódeo gastrintestinal; Resistance.	
Thesagro: 	Caprino; Helminto gastrintestinal; Infecção; Marcador genetico; Nematóide; Resistência.	
Thesaurus Nal: 	Cytokines; Genetic markers; Goats; Infection; Nematode infections; single nucleotide polymorphism.	
Categoria do assunto: 	G Melhoramento Genético	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/item/113908/1/PROCI-2014.00127.pdf	
Registro original: 	Embrapa Caprinos e Ovinos (CNPC)	
Exemplares: 	CNPC - (28382-1) - UPC - AP - DD -  -  -  - DIS