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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria de Alimentos. Para informações adicionais entre em contato com ctaa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
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Data corrente: |
16/12/2020 |
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Data da última atualização: |
05/02/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ROMUALDO, G. R.; SOUZA, I. P. de; SOUZA, L. V. de; PRATA, G. B.; FRAGA-SILVA, T. F. de; SARTORI, A.; BORGUINI, R. G.; SANTIAGO, M. C. P. de A.; FERNANDES, A. A. H.; COGLIATI, B.; BARBOSAN, L. F. |
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Afiliação: |
Guilherme Ribeiro Romualdo, UNESP; Isadora Penedo de Souza, UNESP; Lucas Vilhegas de Souza, UNESP; Gabriel Bacil Prata, UNESP; Thais Fernanda de Campos Fraga-Silva, UNESP; Alexandrina Sartori, UNESP; RENATA GALHARDO BORGUINI, CTAA; MANUELA CRISTINA P DE A SANTIAGO, CTAA; Ana Angélica Henrique Fernandes, UNESP; Bruno Cogliati, USP; Luís Fernando Barbisan, UNESP. |
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Título: |
Beneficial effects of anthocyanin-rich peels of Myrtaceae fruits on chemically-induced liver fibrosis and carcinogenesis in mice. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Food Research International, v. 139, 109964, 2021. p. 1-11. |
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DOI: |
https://doi.org/10.1016/j.foodres.2020.109964 |
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Idioma: |
Inglês |
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Conteúdo: |
Hepatocellular carcinoma (HCC) arising from fibrosis/cirrhosis is the most common type of primary liver cancer. Conversely, a higher intake of fruits and vegetables might play a protective role in HCC risk. Recently, Myrtaceae family tropical fruits have raised great interest due to the high levels of anthocyanins especially in their peels, which are usually discarded upon consumption. Anthocyanins are antioxidant pigments known to have beneficial effects in vivo/in vitro cancer bioassays. Thus, we evaluated whether dietary Myrciaria jaboticaba, Syzygium cumini, and Syzygium malaccense fruit peel powders reduce fibrosis and hepatocarcinogenesis in mice. Female C3H/HeJ mice were submitted to the model of diethylnitrosamine/carbon tetrachloride-induced liver fibrosis and carcinogenesis. Concomitantly, mice received a basal diet containing 2% of M. jaboticaba, S. cumini, or S. malaccense fruit peel powders, obtained by convective drying, for 10 weeks. M. jaboticaba peel powder showed the highest levels of total anthocyanins, while S. cumini peel powder displayed the greatest diversity of these pigments. All Myrtaceae family peel powders reduced the serum levels of the liver injury marker alanine aminotransferase. M. jaboticaba peel feeding reduced the incidence of liver preneoplastic foci, hepatocyte proliferation (Ki-67), and the protein levels of hepato-mitogen tumor necrosis factor-alpha (TNF-?). M. jaboticaba peel feeding also diminished liver lipid peroxidation and increased total glutathione levels. S. cumini peel feeding reduced hepatic collagen, lipid peroxidation, and TNF-? levels while increased catalase activity. Although S. malaccense peel powder, which displayed the lowest anthocyanin levels, decreased oxidative stress, and cytokine levels, no effects were observed on liver fibrosis or preneoplastic lesion outcomes. Findings indicate a protective effect of anthocyanin-rich M. jaboticaba and S. cumini peel powder feeding on preneoplastic lesion development and fibrosis, respectively. Results indicate that differential biological responses may be attributed to distinct anthocyanin profiles and levels, assigning a functional/market value to the underutilized peel fraction. MenosHepatocellular carcinoma (HCC) arising from fibrosis/cirrhosis is the most common type of primary liver cancer. Conversely, a higher intake of fruits and vegetables might play a protective role in HCC risk. Recently, Myrtaceae family tropical fruits have raised great interest due to the high levels of anthocyanins especially in their peels, which are usually discarded upon consumption. Anthocyanins are antioxidant pigments known to have beneficial effects in vivo/in vitro cancer bioassays. Thus, we evaluated whether dietary Myrciaria jaboticaba, Syzygium cumini, and Syzygium malaccense fruit peel powders reduce fibrosis and hepatocarcinogenesis in mice. Female C3H/HeJ mice were submitted to the model of diethylnitrosamine/carbon tetrachloride-induced liver fibrosis and carcinogenesis. Concomitantly, mice received a basal diet containing 2% of M. jaboticaba, S. cumini, or S. malaccense fruit peel powders, obtained by convective drying, for 10 weeks. M. jaboticaba peel powder showed the highest levels of total anthocyanins, while S. cumini peel powder displayed the greatest diversity of these pigments. All Myrtaceae family peel powders reduced the serum levels of the liver injury marker alanine aminotransferase. M. jaboticaba peel feeding reduced the incidence of liver preneoplastic foci, hepatocyte proliferation (Ki-67), and the protein levels of hepato-mitogen tumor necrosis factor-alpha (TNF-?). M. jaboticaba peel feeding also diminished liver lipid peroxidation and increas... Mostrar Tudo |
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Thesaurus Nal: |
Anthocyanins; Fruit peels; Myrciaria; Syzygium cumini. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 03166naa a2200301 a 4500
001 2128263
005 2021-02-05
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.foodres.2020.109964$2DOI
100 1 $aROMUALDO, G. R.
245 $aBeneficial effects of anthocyanin-rich peels of Myrtaceae fruits on chemically-induced liver fibrosis and carcinogenesis in mice.$h[electronic resource]
260 $c2021
520 $aHepatocellular carcinoma (HCC) arising from fibrosis/cirrhosis is the most common type of primary liver cancer. Conversely, a higher intake of fruits and vegetables might play a protective role in HCC risk. Recently, Myrtaceae family tropical fruits have raised great interest due to the high levels of anthocyanins especially in their peels, which are usually discarded upon consumption. Anthocyanins are antioxidant pigments known to have beneficial effects in vivo/in vitro cancer bioassays. Thus, we evaluated whether dietary Myrciaria jaboticaba, Syzygium cumini, and Syzygium malaccense fruit peel powders reduce fibrosis and hepatocarcinogenesis in mice. Female C3H/HeJ mice were submitted to the model of diethylnitrosamine/carbon tetrachloride-induced liver fibrosis and carcinogenesis. Concomitantly, mice received a basal diet containing 2% of M. jaboticaba, S. cumini, or S. malaccense fruit peel powders, obtained by convective drying, for 10 weeks. M. jaboticaba peel powder showed the highest levels of total anthocyanins, while S. cumini peel powder displayed the greatest diversity of these pigments. All Myrtaceae family peel powders reduced the serum levels of the liver injury marker alanine aminotransferase. M. jaboticaba peel feeding reduced the incidence of liver preneoplastic foci, hepatocyte proliferation (Ki-67), and the protein levels of hepato-mitogen tumor necrosis factor-alpha (TNF-?). M. jaboticaba peel feeding also diminished liver lipid peroxidation and increased total glutathione levels. S. cumini peel feeding reduced hepatic collagen, lipid peroxidation, and TNF-? levels while increased catalase activity. Although S. malaccense peel powder, which displayed the lowest anthocyanin levels, decreased oxidative stress, and cytokine levels, no effects were observed on liver fibrosis or preneoplastic lesion outcomes. Findings indicate a protective effect of anthocyanin-rich M. jaboticaba and S. cumini peel powder feeding on preneoplastic lesion development and fibrosis, respectively. Results indicate that differential biological responses may be attributed to distinct anthocyanin profiles and levels, assigning a functional/market value to the underutilized peel fraction.
650 $aAnthocyanins
650 $aFruit peels
650 $aMyrciaria
650 $aSyzygium cumini
700 1 $aSOUZA, I. P. de
700 1 $aSOUZA, L. V. de
700 1 $aPRATA, G. B.
700 1 $aFRAGA-SILVA, T. F. de
700 1 $aSARTORI, A.
700 1 $aBORGUINI, R. G.
700 1 $aSANTIAGO, M. C. P. de A.
700 1 $aFERNANDES, A. A. H.
700 1 $aCOGLIATI, B.
700 1 $aBARBOSAN, L. F.
773 $tFood Research International$gv. 139, 109964, 2021. p. 1-11.
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Registro original: |
Embrapa Agroindústria de Alimentos (CTAA) |
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| Registros recuperados : 24 | |
| 5. |  | BICUDO, S. D.; AZEVEDO, H. C.; MAIA, M. S. S.; SOUSA, D. B.; RODELLO, L. Aspectos peculiares da inseminação artificial em ovinos. Acta Scientiae Veterinariae, Porto Alegre, v. 33, supl 1, p. 127-130, 2005.| Tipo: Artigo em Anais de Congresso / Nota Técnica | Circulação/Nível: -- - -- |
| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 7. | | MAUES, M. M.; LEÃO, N. V. M.; SOUSA, D. B. de. Fenologia reprodutiva de especies arbustivas e arbóreas de vegetação secundária em duas áreas de diferentes idades, no município de Igarapé-Açu (PA). In: SEMINÁRIO DE INICIAÇÃO CIENTÍFICA CNPq/FCAP/EMBRAPA, 6., 1996, Belém, PA. Resumos. Belém, PA: FCAP, 1996. p. 85, 151. Publicado também em Congresso Brasileiro de Iniciação Científica em Ciências Agrárias, 16., 1996, Santa Maria, RS.| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 8. | | SOUSA, D. B. de; MAUES, M. M.; LEÃO, N. V. M. Fenologia reprodutiva de espécies arbustivas e arbóreas em vegetação secundária no Nordeste paraense. In: SEMINÁRIO DE INICIAÇÃO CIENTÍFICA, 5., 1995, Belém, PA. Resumos... Belém, PA: FCAP, Unidade de Apoio à Pesquisa, 1995. p. 58, 148.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 9. | | SOUSA, D. B. A. de; SILVA, K. J. D. e; ROCHA, M. de M.; MENEZES JUNIOR, J. A. de. Competição de linhagens de feijão-caupi, subclasse fradinho, em Teresina, PI. In: JORNADA DE INICIAÇÃO CIENTÍFICA DA EMBRAPA MEIO-NORTE, 3., 2017, Teresina, PI. Anais da III Jornada Científica da Embrapa Meio-Norte. Teresina: Embrapa Meio-Norte, 2017. p. 40.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Meio-Norte. |
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| 10. | | SOUSA, D. B.; BICUDO, S. D.; MANZATO, A. J.; AZEVEDO, H. C.; MAIA, M. S.; RODELLO, L.; SICHERLE, C. C. Ranqueamento qualitativo do sêmen congelado de carneiros através da análise estatística multivariada avaliado pelo sistema Casa e sondas fluorescentes. In: CONGRESSO BRASILEIRO DE REPRODUÇÃO ANIMAL, 17., 2007, Curitiba. Anais... Belo Horizonte: CBRA, 2007. p. 148.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 12. | | MAIA, M. da S.; BICUDO, S. D.; AZEVEDO, H. C.; SICHERLE, C. C.; SOUSA, D. B. de; RODELLO, L. Molity and viability of ram sperm cryopreserved in a Tris-egg yolk extender supplemented with anti-oxidants. Small Ruminant Research, Ney Yourk, v. 85, p. 85-90, 2009. Artigo de periódico.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 13. | | AZEVEDO, H. C.; BICUDO, S. D.; SOUSA, D. B.; MAIA, M. da S.; RODELLO, L.; SICHERLE, C. C. Measurement of sperm capacitation and acrosome reaction - like changes by chlortetracycline test (CTC) can predict the freezability of ram semen? Reproduction in Domestic Animals, Berlin, v. 43, n. 3, p. 70, 2008. Supplement 3, ref. P128. Edição dos Abstracts do 16. International Congress on Animal Reproduction, Budapest, jul. 2008.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Semiárido. |
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| 14. | | AZEVEDO, H. C.; BICUDO, S D.; SOUSA, D. B.; MAIA, M. S.; RODELLO, L.; SICHERLE, C. C. Measurement of sperm capacitation and acrosome reaction - like changes by chortetracycline test (CTC) can predict the freezability of ram semen? In: INTERNATIONAL CONGRESS ON ANIMAL REPRODUCTION, 16., 2008, Budapest. Abstracts... European Society for Domestic Animal Reproduction, 2008. Resumo em anais.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 17. | | MAIA, M. S.; BICUDO, S. D.; AZEVEDO, H. C.; SICHERLE, C. C; SOUSA, D. B.; RODELLO, L. Geração de metabólitos reativos do oxigênio (ROS) em diluentes para a criopreservação de sêmen. In: CONGRESSO BRASILEIRO DE REPRODUÇÃO ANIMAL, 17., 2007, . Anais... Belo Horizonte: CBRA, 2007. p. 198| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 18. | | AZEVEDO, H. C.; BICUDO, S. D.; MAIA, M. da S.; SOUSA, D. B.; RODELLO, L.; SICHERLE, C. C. Influência da crioresistência da membrana plasmática sobre a avaliação computadorizada ma motilidade de espermatozóides ovinos criopreservados. In: SIMPÓSIO INTERNACIONAL SOBRE CAPRINOS E OVINOS DE CORTE, 3., 2007, João Pessoa. Anais... João Pessoa, 2007. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| Registros recuperados : 24 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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