| |
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Arroz e Feijão. Para informações adicionais entre em contato com cnpaf.biblioteca@embrapa.br. |
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Arroz e Feijão. |
|
Data corrente: |
15/04/2016 |
|
Data da última atualização: |
15/04/2016 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
ALVES, N. E. G.; VASCONCELOS, C. M.; BASSINELLO, P. Z.; MEJIA, E. G. de; MARTINO, H. S. D. |
|
Afiliação: |
NATALIA ELIZABETH GALDINO ALVES, UFV; CHRISTIANE MILEIB VASCONCELOS, UNIVERSIDADE FEDERAL DE OURO PRETO; PRISCILA ZACZUK BASSINELLO, CNPAF; ELVIRA GONZALEZ DE MEJIA, UNIVERSITY OF ILLINOIS URBANA, Champaign; HERCIA STAMPINI DUARTE MARTINO, UFV. |
|
Título: |
Digested protein isolate from fresh and stored Carioca beans reduced markers of atherosclerosis in oxidized LDL-induced THP-1 macrophages. |
|
Ano de publicação: |
2016 |
|
Fonte/Imprenta: |
Journal of Functional Foods, v. 24, p. 97-111, 2016. |
|
ISSN: |
1756-4646 |
|
DOI: |
10.1016/j.jff.2016.03.027 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Oxidized LDL (ox-LDL) and its interaction with lectin type ox-LDL receptor (LOX-1) determine atherosclerosis progression. The potential of peptides from digested protein isolate (DPI) derived from fresh and stored Carioca bean (Phaseolus vulgaris L.) to prevent ox-LDL induced inflammation in humanTHP-1 macrophage-like cells was examined here. BRS Pontal (PO) and BRSMG Madreperola (MP) fresh and stored for 6 months were cooked, and protein isolates were digested by pepsin?pancreatin. Peptides from stored Carioca beans decreased prostaglandin E-2 (PGE-2) (from 17.7 to 47%) and tumour necrosis factor-α (TNF-α) (12.3 to 82%). Stored MP (0.01 mg/mL) inhibited reactive oxygen species (ROS). LOX-1 and matrix metalloproteinase-9 (MMP-9) expression were reduced by peptides from all beans. Stored PO and MP digested protein isolates reduced expression of 10 cytokines related to atherosclerosis process. Peptides from Carioca beans presented anti-atherosclerotic properties comparable to simvastatin, which were related to inhibition of LOX-1, MMP-9 and ICAM-1. |
|
Palavras-Chave: |
Bioactive peptides; Lectin type ox-LDL receptor 1; Oxidized LDL. |
|
Thesagro: |
Feijão; Phaseolus vulgaris. |
|
Categoria do assunto: |
Q Alimentos e Nutrição Humana |
|
Marc: |
LEADER 01888naa a2200253 a 4500
001 2043480
005 2016-04-15
008 2016 bl uuuu u00u1 u #d
022 $a1756-4646
024 7 $a10.1016/j.jff.2016.03.027$2DOI
100 1 $aALVES, N. E. G.
245 $aDigested protein isolate from fresh and stored Carioca beans reduced markers of atherosclerosis in oxidized LDL-induced THP-1 macrophages.$h[electronic resource]
260 $c2016
520 $aOxidized LDL (ox-LDL) and its interaction with lectin type ox-LDL receptor (LOX-1) determine atherosclerosis progression. The potential of peptides from digested protein isolate (DPI) derived from fresh and stored Carioca bean (Phaseolus vulgaris L.) to prevent ox-LDL induced inflammation in humanTHP-1 macrophage-like cells was examined here. BRS Pontal (PO) and BRSMG Madreperola (MP) fresh and stored for 6 months were cooked, and protein isolates were digested by pepsin?pancreatin. Peptides from stored Carioca beans decreased prostaglandin E-2 (PGE-2) (from 17.7 to 47%) and tumour necrosis factor-α (TNF-α) (12.3 to 82%). Stored MP (0.01 mg/mL) inhibited reactive oxygen species (ROS). LOX-1 and matrix metalloproteinase-9 (MMP-9) expression were reduced by peptides from all beans. Stored PO and MP digested protein isolates reduced expression of 10 cytokines related to atherosclerosis process. Peptides from Carioca beans presented anti-atherosclerotic properties comparable to simvastatin, which were related to inhibition of LOX-1, MMP-9 and ICAM-1.
650 $aFeijão
650 $aPhaseolus vulgaris
653 $aBioactive peptides
653 $aLectin type ox-LDL receptor 1
653 $aOxidized LDL
700 1 $aVASCONCELOS, C. M.
700 1 $aBASSINELLO, P. Z.
700 1 $aMEJIA, E. G. de
700 1 $aMARTINO, H. S. D.
773 $tJournal of Functional Foods$gv. 24, p. 97-111, 2016.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Arroz e Feijão (CNPAF) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 237 | |
| 4. |  | SANTOS, K. M. O. dos S. Grupo dos óleos e gorduras. In: PHILIPPI, S. T. (Org.). Pirâmide dos alimentos: fundamentos básico da nutrição. Barueri: Manole, 2008. Cap. 7, p. 243-292.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
|    |
| 12. | | SANTOS, K. M.; BRONDANI, C.; BASSINELLO, P. Z. Caracterização de acessos da coleção nuclear brasileira de arroz, cultivados em dois locais, quanto a dois parâmetros de qualidade de grãos. In: SIMPÓSIO LATINO AMERICANO DE CIÊNCIA DE ALIMENTOS, 6., 2005, Campinas. Ciência de alimentos abrindo caminhos para o desenvolvimento científico, tecnológico e industrial. Campinas: Unicamp, 2005.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Arroz e Feijão. |
|  |
| Registros recuperados : 237 | |
|
| Expressão de busca inválida. Verifique!!! |
|
|
