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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
18/04/2023 |
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Data da última atualização: |
28/11/2024 |
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Tipo da produção científica: |
Capítulo em Livro Técnico-Científico |
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Autoria: |
CORREIA, B. S. B.; DALLE PIAGE, P. M. F.; ALMEIDA, L. S.; RIBEIRO, G. H.; PEIXOTO, C. S.; COLNAGO, L. A.; CARDOSO, D. R. |
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Afiliação: |
BANNY SILVA BARBOSA CORREIA, UNIVERSITY OF SAO PAULO; PRISCILA MARQUES FIRMIANO DALLE PIAGGE, UNIVERSITY OF SAO PAULO; LUÍSA SOUZA ALMEIDA, UNIVERSITY OF SAO PAULO; GABRIEL HENRIQUE RIBEIRO GONÇALVES, UNIVERSIDADE FEDERAL DO PARANÁ (UFPR); CRISTINA DE SOUZA PEIXOTO, UNIVERSITY OF SAO PAULO; LUIZ ALBERTO COLNAGO, CNPDIA; DANIEL RODRIGUES CARDOSO, UNIVERSITY OF SAO PAULO. |
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Título: |
The Use of NMR Based Metabolomics to Discriminate Patients with Viral. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
In: COVID-19 Metabolomics and Diagnosis: Chemical Science for Prevention and Understanding Outbreaks of Infectious Diseases. Cham: Springer International Publishing, 2023. |
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Páginas: |
129 - 174 |
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ISBN: |
978-3-031-15889-6 (eletrônico) |
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DOI: |
https://doi.org/10.1007/978-3-031-15889-6_7 |
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Idioma: |
Inglês |
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Conteúdo: |
Infectious diseases are one of the most common conditions impacting global health, being a matter of concern for health agencies due to their contagious capacity and periodic outbreaks of new diseases, such as the global pandemic COVID-19. Viruses are among the main causes of this illness and it is defined as obligate intracellular parasites for their need to have a host cell to live and reproduce, since they won?t produce proteins and compete for nutrients and metabolites leading to the alteration of the host metabolome. The diagnosis of these viral infections can be done by detecting viral particles or components, isolating the virus in cell culture, or even by evaluating immune responses. In this context, metabolomics comes as a very useful tool that reflects all ?omics? techniques and best represents the phenotype. Since water-soluble metabolites and lipids are the major molecular constituents of human plasma, their abnormalities are commonly observed during disease, which contributes to the understanding of physiology and pathology. Nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) are the most widely used techniques in metabolomics. NMR spectroscopy has emerged as a valuable application due to its ability to identify compounds with simple sample preparation, in addition, to being a non-destructive, highly reproducible, and quantitative technique (primary ratio method). These features make NMR a valuable tool that is frequently used in metabolomics analysis, and nowadays used in the diagnosis of viral diseases. Therefore, in this chapter, we will address a short integrative description of viral diseases and diagnostics, metabolomics, and NMR concepts. Furthermore, we will explore the advances in NMR-based metabolomics applied in medicine, and finally, the viral diseases discriminated by NMR-based metabolomics. MenosInfectious diseases are one of the most common conditions impacting global health, being a matter of concern for health agencies due to their contagious capacity and periodic outbreaks of new diseases, such as the global pandemic COVID-19. Viruses are among the main causes of this illness and it is defined as obligate intracellular parasites for their need to have a host cell to live and reproduce, since they won?t produce proteins and compete for nutrients and metabolites leading to the alteration of the host metabolome. The diagnosis of these viral infections can be done by detecting viral particles or components, isolating the virus in cell culture, or even by evaluating immune responses. In this context, metabolomics comes as a very useful tool that reflects all ?omics? techniques and best represents the phenotype. Since water-soluble metabolites and lipids are the major molecular constituents of human plasma, their abnormalities are commonly observed during disease, which contributes to the understanding of physiology and pathology. Nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) are the most widely used techniques in metabolomics. NMR spectroscopy has emerged as a valuable application due to its ability to identify compounds with simple sample preparation, in addition, to being a non-destructive, highly reproducible, and quantitative technique (primary ratio method). These features make NMR a valuable tool that is frequently used in metabolomic... Mostrar Tudo |
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Palavras-Chave: |
NMR; Viral diseases. |
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Categoria do assunto: |
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Marc: |
LEADER 02696naa a2200241 a 4500
001 2153223
005 2024-11-28
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/978-3-031-15889-6_7$2DOI
100 1 $aCORREIA, B. S. B.
245 $aThe Use of NMR Based Metabolomics to Discriminate Patients with Viral.$h[electronic resource]
260 $c2023
300 $a129 - 174
520 $aInfectious diseases are one of the most common conditions impacting global health, being a matter of concern for health agencies due to their contagious capacity and periodic outbreaks of new diseases, such as the global pandemic COVID-19. Viruses are among the main causes of this illness and it is defined as obligate intracellular parasites for their need to have a host cell to live and reproduce, since they won?t produce proteins and compete for nutrients and metabolites leading to the alteration of the host metabolome. The diagnosis of these viral infections can be done by detecting viral particles or components, isolating the virus in cell culture, or even by evaluating immune responses. In this context, metabolomics comes as a very useful tool that reflects all ?omics? techniques and best represents the phenotype. Since water-soluble metabolites and lipids are the major molecular constituents of human plasma, their abnormalities are commonly observed during disease, which contributes to the understanding of physiology and pathology. Nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) are the most widely used techniques in metabolomics. NMR spectroscopy has emerged as a valuable application due to its ability to identify compounds with simple sample preparation, in addition, to being a non-destructive, highly reproducible, and quantitative technique (primary ratio method). These features make NMR a valuable tool that is frequently used in metabolomics analysis, and nowadays used in the diagnosis of viral diseases. Therefore, in this chapter, we will address a short integrative description of viral diseases and diagnostics, metabolomics, and NMR concepts. Furthermore, we will explore the advances in NMR-based metabolomics applied in medicine, and finally, the viral diseases discriminated by NMR-based metabolomics.
653 $aNMR
653 $aViral diseases
700 1 $aDALLE PIAGE, P. M. F.
700 1 $aALMEIDA, L. S.
700 1 $aRIBEIRO, G. H.
700 1 $aPEIXOTO, C. S.
700 1 $aCOLNAGO, L. A.
700 1 $aCARDOSO, D. R.
773 $tIn: COVID-19 Metabolomics and Diagnosis: Chemical Science for Prevention and Understanding Outbreaks of Infectious Diseases. Cham: Springer International Publishing, 2023.
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