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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
25/09/2023 |
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Data da última atualização: |
25/09/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GRIZZO, A.; SANTOS, D. M. dos; COSTA, V. P. V. da; LOPES, R. G.; INADA, N. M.; CORREA, D. S.; CAMPANA-FILHO, S. P. |
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Afiliação: |
Sao Carlos Institute of Chemistry/University of Sao Paulo; Nanotechnology National Laboratory for Agriculture (LNNA); Center for Exact Sciences and Technology, Federal University of Sao Carlos (UFSCar); Sao Carlos Institute of Physics/University of Sao Paulo; Sao Carlos Institute of Physics/University of Sao Paulo; DANIEL SOUZA CORREA, CNPDIA; CAMPANA-FILHO, S. P., Sao Carlos Institute of Chemistry/University of Sao Paulo. |
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Título: |
Multifunctional bilayer membranes composed of poly(lactic acid), beta-chitin whiskers and silver nanoparticles for wound dressing applications. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
International Journal of Biological Macromolecules, v. 251, 126314, 2023. |
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ISSN: |
0141-8130 |
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DOI: |
https://doi.org/10.1016/j.ijbiomac.2023.126314 |
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Idioma: |
Inglês |
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Conteúdo: |
Nanomaterial-based wound dressings have been extensively studied for the treatment of both minor and lifethreatening tissue injuries. These wound dressings must possess several crucial characteristics, such as tissue compatibility, non-toxicity, appropriate biodegradability to facilitate wound healing, effective antibacterial activity to prevent infection, and adequate physical and mechanical strength to withstand repetitive dynamic forces that could potentially disrupt the healing process. Nevertheless, the development of nanostructured wound dressings that incorporate various functional micro- and nanomaterials in distinct architectures, each serving specific purposes, presents significant challenges. In this study, we successfully developed a novel multifunctional wound dressing based on poly(lactic acid) (PLA) fibrous membranes produced by solution-blow spinning (SBS) and electrospinning. The PLA-based membranes underwent surface modifications aimed at tailoring their properties for utilization as effective wound dressing platforms. Initially, beta-chitin whiskers were deposited onto the membrane surface through filtration, imparting hydrophilic character. Afterward, silver nanoparticles (AgNPs) were incorporated onto the beta-chitin layer using a spray deposition method, resulting in platforms with antimicrobial properties against both Staphylococcus aureus and Escherichia coli. Cytotoxicity studies demonstrated the biocompatibility of the membranes with the neonatal human dermal fibroblast (HDFn) cell line. Moreover, bilayer membranes exhibited a high surface area and porosity (> 80%), remarkable stability in aqueous media, and favorable mechanical properties, making them promising candidates for application as multifunctional wound dressings. MenosNanomaterial-based wound dressings have been extensively studied for the treatment of both minor and lifethreatening tissue injuries. These wound dressings must possess several crucial characteristics, such as tissue compatibility, non-toxicity, appropriate biodegradability to facilitate wound healing, effective antibacterial activity to prevent infection, and adequate physical and mechanical strength to withstand repetitive dynamic forces that could potentially disrupt the healing process. Nevertheless, the development of nanostructured wound dressings that incorporate various functional micro- and nanomaterials in distinct architectures, each serving specific purposes, presents significant challenges. In this study, we successfully developed a novel multifunctional wound dressing based on poly(lactic acid) (PLA) fibrous membranes produced by solution-blow spinning (SBS) and electrospinning. The PLA-based membranes underwent surface modifications aimed at tailoring their properties for utilization as effective wound dressing platforms. Initially, beta-chitin whiskers were deposited onto the membrane surface through filtration, imparting hydrophilic character. Afterward, silver nanoparticles (AgNPs) were incorporated onto the beta-chitin layer using a spray deposition method, resulting in platforms with antimicrobial properties against both Staphylococcus aureus and Escherichia coli. Cytotoxicity studies demonstrated the biocompatibility of the membranes with the neonatal hu... Mostrar Tudo |
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Palavras-Chave: |
Beta-chitin whiskers; Biocompatible material; Electrospun nanofibers; Natural polymer; Solution blow spinning; Wound dressing. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02746naa a2200289 a 4500
001 2156857
005 2023-09-25
008 2023 bl uuuu u00u1 u #d
022 $a0141-8130
024 7 $ahttps://doi.org/10.1016/j.ijbiomac.2023.126314$2DOI
100 1 $aGRIZZO, A.
245 $aMultifunctional bilayer membranes composed of poly(lactic acid), beta-chitin whiskers and silver nanoparticles for wound dressing applications.$h[electronic resource]
260 $c2023
520 $aNanomaterial-based wound dressings have been extensively studied for the treatment of both minor and lifethreatening tissue injuries. These wound dressings must possess several crucial characteristics, such as tissue compatibility, non-toxicity, appropriate biodegradability to facilitate wound healing, effective antibacterial activity to prevent infection, and adequate physical and mechanical strength to withstand repetitive dynamic forces that could potentially disrupt the healing process. Nevertheless, the development of nanostructured wound dressings that incorporate various functional micro- and nanomaterials in distinct architectures, each serving specific purposes, presents significant challenges. In this study, we successfully developed a novel multifunctional wound dressing based on poly(lactic acid) (PLA) fibrous membranes produced by solution-blow spinning (SBS) and electrospinning. The PLA-based membranes underwent surface modifications aimed at tailoring their properties for utilization as effective wound dressing platforms. Initially, beta-chitin whiskers were deposited onto the membrane surface through filtration, imparting hydrophilic character. Afterward, silver nanoparticles (AgNPs) were incorporated onto the beta-chitin layer using a spray deposition method, resulting in platforms with antimicrobial properties against both Staphylococcus aureus and Escherichia coli. Cytotoxicity studies demonstrated the biocompatibility of the membranes with the neonatal human dermal fibroblast (HDFn) cell line. Moreover, bilayer membranes exhibited a high surface area and porosity (> 80%), remarkable stability in aqueous media, and favorable mechanical properties, making them promising candidates for application as multifunctional wound dressings.
653 $aBeta-chitin whiskers
653 $aBiocompatible material
653 $aElectrospun nanofibers
653 $aNatural polymer
653 $aSolution blow spinning
653 $aWound dressing
700 1 $aSANTOS, D. M. dos
700 1 $aCOSTA, V. P. V. da
700 1 $aLOPES, R. G.
700 1 $aINADA, N. M.
700 1 $aCORREA, D. S.
700 1 $aCAMPANA-FILHO, S. P.
773 $tInternational Journal of Biological Macromolecules$gv. 251, 126314, 2023.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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| Registros recuperados : 12 | |
| 1. |  | ROSA, J. O.; VARGAS, G.; BERNARDES, P. A.; FIGUEIREDO, E. A. P. de; LEDUR, M. C.; MUNARI, D. P. Avaliação da endogamia de uma população de aves de postura White Leghorn. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 10., 2013, Uberaba. Anais... Belo Horizonte: SBMA, 2013.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 3. | | ROSA, J. O.; SAVEGNAGO, R. P.; MARCHESI, J. A. P.; CRUZ, V. A. R. da; LEDUR, M. C.; MUNARI, D. P. Análise de componentes principais dos valores genéticos para peso corporal e de órgãos de aves de corte. In: CURSO DE INVERNO DE GENÉTICA, 7., FACAV-UNESP, 2016. Publicado: Ciência & Tecnologia: Fatec-JB, Jaboticabal, v. 8, n. 1, 2016. Número especial 2.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 4. | | BAINY, A. M.; SAVEGNAGO, R. P.; FREITAS, L. A. de; NUNES, B. do N.; ROSA, J. O.; LEDUR, M. C.; MUNARI, D. P. Estimates of genetic parameters and cluster analyses for carcass and meat quality traits in birds. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 52, n. 3, p. 205-213, mar. 2017. Título em inglês: Estimativa de parâmetros genéticos e análises de agrupamento para características de carcaça e qualidade da carne em aves.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Suínos e Aves; Embrapa Unidades Centrais. |
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| 5. | | VENTURINI, G. C.; CRUZ, V. A. R. da; ROSA, J. O.; BALDI, F.; EL FARO, L.; LEDUR, M. C.; PEIXOTO, J. de O.; MUNARI, D. P. Genetic and phenotypic parameters of carcass and organ traits of broiler chickens. Genetics and Molecular Research, Ribeirão Preto, v. 13, n. 4, p. 10294-10300.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 6. | | ROSA, J. O.; PIRES, B. C.; CHUD, T. C. S.; BUZANSKAS, M. E.; CRUZ, V. A. R.; LEDUR, M. C.; SCHMIDT, G. S.; MUNARI, D. P. Genetic parameters reproductive traits in a strain if laying hens. In: CONGRESSO BRASILEIRO DE GENÉTICA, 60., 2014, Guarujá. Resumos? Ribeirão Preto: Sociedade Brasileira de Genética, 2014. p. 24| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 7. | | CRUZ, V. A. R. da; IBELLI, A. M. G.; BUZANSKAS, M. E.; ROSA, J. O.; CHUD, T. C. S.; LEDUR, M. C.; PEIXOTO, J. de O.; MUNARI, D. P. Association of Apolipoprotein B gene with carcass, performance, and organ traits in a paternal broiler line. In: REUNIÃO ANNUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 51, 2014, Barra dos Coqueiros. Anais ... Barra dos Coqueiros: SBZ, 2014. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 8. | | CHUD, T. C. S.; ROSA, J. O.; SILVA, M. V. G. B.; SILVA, T. B. R.; OLIVEIRA, G. A.; VENTURINI, G. C.; BALDI REY, F. S.; MUNARI, D. P. Genome-wide identification of copy number variation regions in Girolando cattle. In: CONGRESSO BRASILEIRO DE GENÉTICA, 61., 2015, Águas de Lindóia. Resumos... Ribeirão Preto: Sociedade Brasileira de Genética, 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 9. | | PIRES, B. C.; THOLON, P.; BUZANSKAS, M. E.; SBARDELLA, A. P.; ROSA, J. O.; SILVA, L. O. C. da; TORRES JUNIOR, R. A. de A.; MUNARI, D. P.; ALENCAR, M. M. de. Genetic analyses on bodyweight, reproductive, and carcass traits in composite beef cattle. Animal Production Science, v. 57, n. 3, 415-421, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 10. | | CHUD, T. C. S.; VENTURA, R. V.; SCHENKEL, F. S.; CARVALHEIRO, R.; BUZANSKAS, M. E.; ROSA, J. O.; MUDADU, M. de A.; SILVA, M. V. G. B.; MARCONDES, C. R.; REGITANO, L. C. de A.; MUNARI, D. P. Strategies for genotype imputation in composite beef cattle. BMC Genetics, v. 16, p. 99, 2015. 10 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 11. | | ROSA, J. O.; VENTURINI, G. C.; CHUD, T. C. S.; PIRES, B. C.; BUZANSKAS, M. E.; STAFUZZA, N. B.; FURQUIM, G. R.; CRUZ, V. A. R. da; SCHMIDT, G. S.; FIGUEIREDO, E. A. P. de; LIMA, V. F. M. H. de; LEDUR, M. C.; MUNARI, D. P. Bayesian inference of genetic parameters for reproductive and performance traits in white leghorn hens. Czech Journal of Animal Science, v. 63 n. 6, p. 230-236, 2018.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 12. | | CHUD, T. C. S.; VENTURA, R. V.; SCHENKEL, F. S.; CARVALHEIRO, R.; BUZANSKAS, M. E.; ROSA, J. O.; MUDADU, M. de A.; SILVA, M. V. G. B.; MOKRY, F. B.; MARCONDES, C. R.; REGITANO, L. C. de A.; MUNARI, D. P. Strategies for genotype imputation in composite beef cattle. BMC Genomics, v. 16, n. 99, 2015. 10 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| Registros recuperados : 12 | |
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