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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Corte. Para informações adicionais entre em contato com biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Gado de Corte. |
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Data corrente: |
17/07/2018 |
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Data da última atualização: |
27/09/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ANDREOTTI, R.; GIACHETTO, P. F.; CUNHA, R. C. |
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Afiliação: |
RENATO ANDREOTTI E SILVA, CNPGC; POLIANA FERNANDA GIACHETTO, CNPTIA; RODRIGO CASQUERO CUNHA, Bolsista PNPD/Capes. |
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Título: |
Advances in tick vaccinology in Brazil: from gene expression to immunoprotection. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Frontiers in Bioscience - Scholar, v. 10, n. 1, p. 127-142, Jan. 2018 |
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Idioma: |
Inglês |
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Conteúdo: |
Rhipicephalus (Boophilus) microplus has substantial economic impact on the cattle breeding industry and, chemical control and tick resistance development are the major concern. There is a worldwide search for new options, and control using vaccines has been the main focus nowadays. Studies performed in Brazil found that Bm86-based immunization of bovines reduced the infestation of R. (B.) microplus of vaccinated bovines by 45% to 60%. Native Boophilus microplus tripsin inhibitors (BmTIs) with trypsin-, kallikrein-, and elastase-inhibiting activities have been used as immunogens in bovines reaching 72.8.% of efficacy. The reverse vaccinology approach has also been used for antigen search using transcriptome analysis to identify and characterize potential antigens. Study has generated more than 600 million sequences using RNA-seq of larvae, nymphs, salivary glands, intestines, and ovaries of the tick R. (B) microplus. Based on the set of transcripts obtained using this strategy, a total of 20,326 protein sequences have been identified. A pipeline analysis built in house identified the protein sequences that were most likely to be immunogenic based on the overall structural characteristic analysis. |
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Thesagro: |
Vacina. |
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Thesaurus Nal: |
Gene expression; Rhipicephalus microplus; Transcriptome; Vaccines. |
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Categoria do assunto: |
--
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 01823naa a2200205 a 4500
001 2093371
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008 2018 bl uuuu u00u1 u #d
100 1 $aANDREOTTI, R.
245 $aAdvances in tick vaccinology in Brazil$bfrom gene expression to immunoprotection.$h[electronic resource]
260 $c2018
520 $aRhipicephalus (Boophilus) microplus has substantial economic impact on the cattle breeding industry and, chemical control and tick resistance development are the major concern. There is a worldwide search for new options, and control using vaccines has been the main focus nowadays. Studies performed in Brazil found that Bm86-based immunization of bovines reduced the infestation of R. (B.) microplus of vaccinated bovines by 45% to 60%. Native Boophilus microplus tripsin inhibitors (BmTIs) with trypsin-, kallikrein-, and elastase-inhibiting activities have been used as immunogens in bovines reaching 72.8.% of efficacy. The reverse vaccinology approach has also been used for antigen search using transcriptome analysis to identify and characterize potential antigens. Study has generated more than 600 million sequences using RNA-seq of larvae, nymphs, salivary glands, intestines, and ovaries of the tick R. (B) microplus. Based on the set of transcripts obtained using this strategy, a total of 20,326 protein sequences have been identified. A pipeline analysis built in house identified the protein sequences that were most likely to be immunogenic based on the overall structural characteristic analysis.
650 $aGene expression
650 $aRhipicephalus microplus
650 $aTranscriptome
650 $aVaccines
650 $aVacina
700 1 $aGIACHETTO, P. F.
700 1 $aCUNHA, R. C.
773 $tFrontiers in Bioscience - Scholar$gv. 10, n. 1, p. 127-142, Jan. 2018
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Embrapa Gado de Corte (CNPGC) |
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| Registros recuperados : 2 | |
| 1. |  | QUEZADA, M.; PASTINA, M. M.; RAVEST, G.; SILVA, P.; VIGNALE, B.; CABRERA, D.; HINRICHSEN, P.; GARCIA, A. A. F.; PRITSCH, C. A first genetic map of Acca sellowiana based on ISSR, AFLP and SSR markers. Scientia Horticulturae, v. 169, p. 138-146, 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 2. | | BONIFACINO, J. M.; MAILHOS, A.; MARCHESI, E.; ROSSADO, A.; HARETCHE, F.; ROSALES, A. G.; BRUSSA, C.; MORENTE, P. M.; SPERONI, G.; VALTIERRA, V.; TORANZA, C.; PAÑELLA, P.; LEZAMA, F.; COSSE, M.; GRATTAROLA, F.; PRELIASCO, M.; BEYHAUT, R.; ZABALETA, M.; CAIRELLO, F.; HEIDEN, G.; IGANCI, J.; WURDACK, K. J.; BONIFACINO, J. M.; MAILHOS, A.; MARCHESI, E.; ROSSADO, A.; HARETCHE, F.; ROSALES, A. G.; BRUSSA, C.; MORENTE, P. M.; SPERONI, G.; VALTIERRA, V.; TORANZA, C.; PAÑELLA, P.; LEZAMA, F.; COSSE, M.; GRATTAROLA, F.; PRELIASCO, M.; BERAZATEGUI, P.; BEYHAUT, R.; ZABALETA, M.; CAIRELLO, F.; HEIDEN, G.; IGANCI, J.; WURDACK, K. J.; UNDEFINED, U.; AMBITE, S.; ANDRADE, B. O.; ANZUINELLI, M.; ARCILA‐LOPERA, A.; UGON, P. A.; BARTOLI, A.; MUÑOZ, D. B.; BELGRANO, M.; BERI, Á.; BERRUTI, A.; BERRY, P.; BOGGIANO, P. R.; BOLDRINI, I.; BORDIGNON, S.; BRUSSA, P.; BUENO, V. R.; BÜNEKER, H. M.; CHAMORRO, D. C.; CRISCI, J. V.; DAVIES, P.; PUERTO, O. D.; DÍAZ, M.; DONADÍO, S.; ELY, C.; EZCURRA, C.; FAGÚNDEZ‐PACHÓN, C.; FORTUNATO, R.; GADEA, F.; GAIERO, P.; GOLDENBERG, R.; GONZÁLEZ, S. E.; GRELA, I. A.; GREPPI, J. A.; GRINGS, M.; OLVEYRA, P. H.; HOAG, C.; JAURENA, M.; JOLOCHIN, G.; KATINAS, L.; KÖHLER, M.; LANDRUM, L.; LUCAS, D. B.; LUPO, S.; MANDEL, J. R.; MARTÍNEZ, G.; MELLO, A.; MENDOZA‐DÍAZ, N.; METZING, D.; MEYER, F. S.; MICHELANGELI, F. A.; MONGE, M.; MORAN, R.; MUÑOZ, F.; NOLI, F.; O'LEARY, N.; OLORIZ, M.; PEDRERO, E.; PÉREZ, C.; PIASTRI, S.; MARTÍNEZ, A. P.; PONCE, M.; PRADO, J.; PRITSCH, C.; PUPPO, M.; QUEZADA, M.; RIVAS, M.; ROSSINI, C.; SANCHO, G.; MELLO, A. S. de; SCHIAVINATO, D.; SOUZA‐PÉREZ, M.; SPERANZA, P. R.; SUÁREZ, G.; TARDÁGUILA, A.; TRUJILLO, C.; URTUBEY, E.; VAIO, M.; VALDIVIA, M.; VIDAL, R.; BARRETO, J. V.; WELKER, C. A.; ZAMENGO, H.; ZULOAGA, F. O.; UY‐BOL, U. Uruguay's Online Flora: A new resource connecting science, society, and conservation. TAXON, v. 75, n. 2, 2025.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| Registros recuperados : 2 | |
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