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 | Acesso ao texto completo restrito à biblioteca da Embrapa Rondônia. Para informações adicionais entre em contato com cpafro.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Rondônia. |
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Data corrente: |
14/08/2013 |
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Data da última atualização: |
14/08/2013 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
AKBAR, H.; SCHMITT, E.; BALLOU, M. A.; CORRÊA, M. N.; DEPETERS, E. J.; LOOR, J. J. |
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Afiliação: |
haji Akbar, University of illinois, Urbana; EDUARDO SCHMITT, CPAF-RO; Michael A. Ballou, Texas Tech University; Marcio N. Corrêa, NUPeeC, UFPel; Edward J. DePeter, University of California; Juan J. Loor, University of illinois, Urbana. |
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Título: |
Dietary Lipid During Late-pregnancy and early-Lactation to Manipulate Metabolic and Inflammatory Gene Network Expression in Dairy Cattle Liver with a Focus on PPARs. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
Gene Regulation and Systems Biology, v. 7, p. 103?123, 2013. |
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Idioma: |
Inglês |
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Conteúdo: |
Polyunsaturated (PUFA) long-chain fatty acids (LCFAs) are more potent in eliciting molecular and tissue functional changes in monogastrics than saturated LCFA. From −21 through 10 days relative to parturition dairy cows were fed no supplemental LCFA (control), saturated LCFA (SFAT; mainly 16:0 and 18:0), or fish oil (FISH; high-PUFA). Twenty-seven genes were measured via quantitative RT-PCR in liver tissue on day −14 and day 10. Expression of nuclear receptor co-activators (CARM1, MED1), LCFA metabolism (ACSL1, SCD, ACOX1), and inflammation (IL6, TBK1, IKBKE) genes was lower with SFAT than control on day −14. Expression of SCD, however, was markedly lower with FISH than control or SFAT on both −14 and 10 days. FISH led to further decreases in expression on day 10 of LCFA metabolism (CD36, PLIN2, ACSL1, ACOX1), intracellular energy (UCP2, STK11, PRKAA1), de novo cholesterol synthesis (SREBF2), inflammation (IL6, TBK1, IKBKE), and nuclear receptor signaling genes (PPARD, MED1, NRIP1). No change in expression was observed for PPARA and RXRA. The increase of DGAT2, PLIN2, ACSL1, and ACOX1 on day 10 versus −14 in cows fed SFAT suggested upregulation of both beta-oxidation and lipid droplet (LD) formation. However, liver triacylglycerol concentration was similar among treatments. The hepatokine FGF21 and the gluconeogenic genes PC and PCK1 increased markedly on day 10 versus −14 only in controls. At the levels supplemented, the change in the profile of metabolic genes after parturition in cows fed saturated fat suggested a greater capacity for uptake of fatty acids and intracellular handling without excessive storage of LD. MenosPolyunsaturated (PUFA) long-chain fatty acids (LCFAs) are more potent in eliciting molecular and tissue functional changes in monogastrics than saturated LCFA. From −21 through 10 days relative to parturition dairy cows were fed no supplemental LCFA (control), saturated LCFA (SFAT; mainly 16:0 and 18:0), or fish oil (FISH; high-PUFA). Twenty-seven genes were measured via quantitative RT-PCR in liver tissue on day −14 and day 10. Expression of nuclear receptor co-activators (CARM1, MED1), LCFA metabolism (ACSL1, SCD, ACOX1), and inflammation (IL6, TBK1, IKBKE) genes was lower with SFAT than control on day −14. Expression of SCD, however, was markedly lower with FISH than control or SFAT on both −14 and 10 days. FISH led to further decreases in expression on day 10 of LCFA metabolism (CD36, PLIN2, ACSL1, ACOX1), intracellular energy (UCP2, STK11, PRKAA1), de novo cholesterol synthesis (SREBF2), inflammation (IL6, TBK1, IKBKE), and nuclear receptor signaling genes (PPARD, MED1, NRIP1). No change in expression was observed for PPARA and RXRA. The increase of DGAT2, PLIN2, ACSL1, and ACOX1 on day 10 versus −14 in cows fed SFAT suggested upregulation of both beta-oxidation and lipid droplet (LD) formation. However, liver triacylglycerol concentration was similar among treatments. The hepatokine FGF21 and the gluconeogenic genes PC and PCK1 increased markedly on day 10 versus −14 only in controls. At the levels supplemented, the change in the pro... Mostrar Tudo |
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Palavras-Chave: |
Fat supplementation; Hepatic gene network; Rede de gene hepática; Suplementação de gordura; Vacas leiteiras. |
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Thesaurus Nal: |
Dairy cows. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02512naa a2200253 a 4500
001 1964101
005 2013-08-14
008 2013 bl uuuu u00u1 u #d
100 1 $aAKBAR, H.
245 $aDietary Lipid During Late-pregnancy and early-Lactation to Manipulate Metabolic and Inflammatory Gene Network Expression in Dairy Cattle Liver with a Focus on PPARs.$h[electronic resource]
260 $c2013
520 $aPolyunsaturated (PUFA) long-chain fatty acids (LCFAs) are more potent in eliciting molecular and tissue functional changes in monogastrics than saturated LCFA. From −21 through 10 days relative to parturition dairy cows were fed no supplemental LCFA (control), saturated LCFA (SFAT; mainly 16:0 and 18:0), or fish oil (FISH; high-PUFA). Twenty-seven genes were measured via quantitative RT-PCR in liver tissue on day −14 and day 10. Expression of nuclear receptor co-activators (CARM1, MED1), LCFA metabolism (ACSL1, SCD, ACOX1), and inflammation (IL6, TBK1, IKBKE) genes was lower with SFAT than control on day −14. Expression of SCD, however, was markedly lower with FISH than control or SFAT on both −14 and 10 days. FISH led to further decreases in expression on day 10 of LCFA metabolism (CD36, PLIN2, ACSL1, ACOX1), intracellular energy (UCP2, STK11, PRKAA1), de novo cholesterol synthesis (SREBF2), inflammation (IL6, TBK1, IKBKE), and nuclear receptor signaling genes (PPARD, MED1, NRIP1). No change in expression was observed for PPARA and RXRA. The increase of DGAT2, PLIN2, ACSL1, and ACOX1 on day 10 versus −14 in cows fed SFAT suggested upregulation of both beta-oxidation and lipid droplet (LD) formation. However, liver triacylglycerol concentration was similar among treatments. The hepatokine FGF21 and the gluconeogenic genes PC and PCK1 increased markedly on day 10 versus −14 only in controls. At the levels supplemented, the change in the profile of metabolic genes after parturition in cows fed saturated fat suggested a greater capacity for uptake of fatty acids and intracellular handling without excessive storage of LD.
650 $aDairy cows
653 $aFat supplementation
653 $aHepatic gene network
653 $aRede de gene hepática
653 $aSuplementação de gordura
653 $aVacas leiteiras
700 1 $aSCHMITT, E.
700 1 $aBALLOU, M. A.
700 1 $aCORRÊA, M. N.
700 1 $aDEPETERS, E. J.
700 1 $aLOOR, J. J.
773 $tGene Regulation and Systems Biology$gv. 7, p. 103?123, 2013.
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Embrapa Rondônia (CPAF-RO) |
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| Registros recuperados : 3 | |
| 1. |  | BERNARDI, A. C. de C.; PITRAT, T.; RABELLO, L. M.; PEZZOPANE, J. R. M.; BOSI, C.; MAZZUCO, G. G.; BETTIOL, G. M. Differences in soil electrical resistivity tomography due to soil water contents in an integrated agricultural system. Pesquisa Agropecuária Brasileira, Brasília, v.54, e00774, p. 1-5, 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Unidades Centrais. |
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| 2. | | SANTOS, D. P.; PITRAT, T.; RABELLO, L. M.; INAMASU, R. Y.; BETTIOL, G. M.; PEZZOPANE, J. R. M.; BERNARDI, A. C. de C. Resistividade elétrica do solo para o estabelecimento de zonas de manejo e em um sistema de integração lavoura-pecuária-floresta. In: JORNADA CIENTÍFICA - EMBRAPA SÃO CARLOS, 8., 2016, São Carlos, SP. Anais... São Carlos: Embrapa Instrumentação: Embrapa Pecuária Sudeste, 2016. p.22. Editores técnicos: Wilson Tadeu Lopes da Silva, José Manoel Marconcini, Maria Alice Martins, Lucimara Aparecida Forato, Paulino Ribeiro Villas Boas. (Embrapa Instrumentação. Documentos, 61).| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação; Embrapa Pecuária Sudeste. |
|  |
| 3. | | BERNARDI, A. C. de C.; PITRAT, T.; RABELLO, L. M.; PEZZOPANE, J. R. M.; BOSI, C.; MAZZUCO, G. G.; BETTIOL, G. M. Soil electrical resistivity at different water contents in an integrated crop-livestock-forest system in Brazil. Advances in Animal Biosciences, v. 8, n. 2, p. 885-886, July 2017. Papers presented at the 11th European Conference on Precision Agriculture (ECPA 2017), John McIntyre Centre, Edinburgh, UK, July 16-20 2017.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Cerrados; Embrapa Pecuária Sudeste. |
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| Registros recuperados : 3 | |
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