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Registro Completo |
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Biblioteca(s): |
Embrapa Soja. |
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Data corrente: |
15/02/2012 |
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Data da última atualização: |
31/03/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CARRARA, V. da S.; AMADO, C. B.; MELO, J. O. de; MANDARINO, J. M. G.; CORTEZ, D. A. G. |
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Afiliação: |
VANESSA DA SILVA CARRARA, UEM; CIOMAR BERSANI AMADO, UEM; JULIANA OLIVEIRA DE MELO, UEM; JOSE MARCOS GONTIJO MANDARINO, CNPSO; DIÓGENES APARÍCIO GARCIA CORTEZ, UEM. |
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Título: |
Evaluation of soybean methanol fraction on acute inflammation. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Journal of Medicinal Food, v. 14, n. 12, p. 1570-1575, 2011. |
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DOI: |
10.1089/jmf.2010.0320 |
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Idioma: |
Inglês |
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Conteúdo: |
Soybeans have been of interest of researchers because of the presence of isoflavones, a subclass of flavonoids, which have demonstrated anti-inflammatory activity. The aim of this study was investigate the anti-inflammatory activity of the methanol fraction from soybean, which contains mainly isoflavone glucosides and malonylglucosides. The anti-inflammatory activity of the methanol fraction from soybean was studied using croton oil?induced mouse ear edema and carrageenan-induced pleurisy models. The methanol fraction inhibited the ear edema in a dose-dependent manner: 0.625 mg/kg by 44.23% (P < .05), 1.25 mg/kg by 60.68% (P < .01), and 2.5 mg/kg by 65.68% (P < .01). Myeloperoxidase enzyme activity was reduced at the dose of 2.5 mg/kg (64.79%, P < .05). No effects were seen on carrageenan-induced pleurisy at different doses of the methanol fraction (100 or 400 mg/kg). These results demonstrated that the methanol fraction containing conjugated isoflavones showed topical anti-inflammatory activity. There was no acute toxicity in Swiss mice after oral administration of the fraction, at doses of 1,000, 2,000, 3,000, and 4,000 mg/kg. |
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Thesagro: |
Antiinflamatório; Soja. |
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Thesaurus Nal: |
Acute toxicity; Anti-inflammatory activity; Isoflavones; Soybeans. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 01881naa a2200253 a 4500
001 1915573
005 2025-03-31
008 2011 bl uuuu u00u1 u #d
024 7 $a10.1089/jmf.2010.0320$2DOI
100 1 $aCARRARA, V. da S.
245 $aEvaluation of soybean methanol fraction on acute inflammation.$h[electronic resource]
260 $c2011
520 $aSoybeans have been of interest of researchers because of the presence of isoflavones, a subclass of flavonoids, which have demonstrated anti-inflammatory activity. The aim of this study was investigate the anti-inflammatory activity of the methanol fraction from soybean, which contains mainly isoflavone glucosides and malonylglucosides. The anti-inflammatory activity of the methanol fraction from soybean was studied using croton oil?induced mouse ear edema and carrageenan-induced pleurisy models. The methanol fraction inhibited the ear edema in a dose-dependent manner: 0.625 mg/kg by 44.23% (P < .05), 1.25 mg/kg by 60.68% (P < .01), and 2.5 mg/kg by 65.68% (P < .01). Myeloperoxidase enzyme activity was reduced at the dose of 2.5 mg/kg (64.79%, P < .05). No effects were seen on carrageenan-induced pleurisy at different doses of the methanol fraction (100 or 400 mg/kg). These results demonstrated that the methanol fraction containing conjugated isoflavones showed topical anti-inflammatory activity. There was no acute toxicity in Swiss mice after oral administration of the fraction, at doses of 1,000, 2,000, 3,000, and 4,000 mg/kg.
650 $aAcute toxicity
650 $aAnti-inflammatory activity
650 $aIsoflavones
650 $aSoybeans
650 $aAntiinflamatório
650 $aSoja
700 1 $aAMADO, C. B.
700 1 $aMELO, J. O. de
700 1 $aMANDARINO, J. M. G.
700 1 $aCORTEZ, D. A. G.
773 $tJournal of Medicinal Food$gv. 14, n. 12, p. 1570-1575, 2011.
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