| |
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Gado de Leite. |
|
Data corrente: |
03/12/2018 |
|
Data da última atualização: |
24/01/2023 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
BARROS, P. A. V. de; ANDRADE, M. E. R.; GENEROSO, S. de V.; MIRANDA, S. E. M.; REIS, D. C. dos; LEOCÁDIO, P. C. L.; SOUZA, E. L. de S. e; MARTINS, F. dos S.; GAMA, M. A. S. da; CASSALI, G. D.; LEITE, J. I. A.; FERNANDES, S. O. A.; CARDOSO, V. N. |
|
Afiliação: |
PATRÍCIA APARECIDA VIEIRA DE BARROS, UFMG; MARIA EMÍLIA RABELO ANDRADE, UFMG; SIMONE DE VASCONCELOS GENEROSO, UFMG; SUED EUSTÁQUIO MENDES MIRANDA, UFMG; DIEGO CARLOS DOS REIS, UFMG; PAOLA CAROLINE LACERDA LEOCÁDIO, UFMG; ÉRICKA LORENNA DE SALES E SOUZA, UFMG; FLAVIANO DOS SANTOS MARTINS, UFMG; MARCO ANTONIO SUNDFELD DA GAMA, CNPGL; GEOVANNI DANTAS CASSALI, UFMG; JACQUELINE ISAURA ALVAREZ LEITE, UFMG; SIMONE ODÍLIA ANTUNES FERNANDES, UFMG; VALBERT NASCIMENTO CARDOSO, UFMG. |
|
Título: |
Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model. |
|
Ano de publicação: |
2018 |
|
Fonte/Imprenta: |
Biomedicine & Pharmacotherapy, v. 103, p. 1567-1576, 2018. |
|
DOI: |
10.1016/j.biopha.2018.04.133 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Abstract BACKGROUND: Studies have showed the protective effects of conjugated linoleic acid (CLA) on intestinal epithelium, modulating host immune and inflammatory responses on intestinal diseases. OBJECTIVE: To evaluate the preventive effects of CLA on the intestinal mucositis induced by 5-FU in a murine model. METHODS: Sixty-four BALB/c mice were randomly divided into four groups: Control (CTL), fed a standard chow diet; CLAs, fed a diet supplemented with CLA; Mucositis (5-FU), fed a standard chow diet and underwent mucositis induction and CLAs 5-FU, fed a diet supplemented with CLA and underwent mucositis induction. Mucositis was induced by intraperitoneal injection of 300 mg/kg 5-FU. After 72 h, the animals were euthanized and intestinal permeability, bacterial translocation, inflammatory mediators, and intestinal histology were evaluated. RESULTS: Mice in the CLAs 5-FU group showed reduced weight loss compared to those in the 5-FU group (p < 0.005). Furthermore, the results also showed that the treatment with CLA reduced intestinal permeability, bacterial translocation, and biomarkers of inflammatory response besides minor damage to ZO-1 and occludin with maintenance of the integrity of the intestinal epithelium and a favorable balance between the inflammatory and regulatory cytokines. CONCLUSION: This study suggests that CLA reduced the adverse effects from 5-FU administration on the intestinal mucosa. |
|
Palavras-Chave: |
Bacterial translocation; Conjugated linoleic acids; Intestinal damage; Mucositis; Tight junction protein. |
|
Thesaurus Nal: |
Cytokines. |
|
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
|
Marc: |
LEADER 02555naa a2200349 a 4500
001 2100591
005 2023-01-24
008 2018 bl uuuu u00u1 u #d
024 7 $a10.1016/j.biopha.2018.04.133$2DOI
100 1 $aBARROS, P. A. V. de
245 $aConjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model.$h[electronic resource]
260 $c2018
520 $aAbstract BACKGROUND: Studies have showed the protective effects of conjugated linoleic acid (CLA) on intestinal epithelium, modulating host immune and inflammatory responses on intestinal diseases. OBJECTIVE: To evaluate the preventive effects of CLA on the intestinal mucositis induced by 5-FU in a murine model. METHODS: Sixty-four BALB/c mice were randomly divided into four groups: Control (CTL), fed a standard chow diet; CLAs, fed a diet supplemented with CLA; Mucositis (5-FU), fed a standard chow diet and underwent mucositis induction and CLAs 5-FU, fed a diet supplemented with CLA and underwent mucositis induction. Mucositis was induced by intraperitoneal injection of 300 mg/kg 5-FU. After 72 h, the animals were euthanized and intestinal permeability, bacterial translocation, inflammatory mediators, and intestinal histology were evaluated. RESULTS: Mice in the CLAs 5-FU group showed reduced weight loss compared to those in the 5-FU group (p < 0.005). Furthermore, the results also showed that the treatment with CLA reduced intestinal permeability, bacterial translocation, and biomarkers of inflammatory response besides minor damage to ZO-1 and occludin with maintenance of the integrity of the intestinal epithelium and a favorable balance between the inflammatory and regulatory cytokines. CONCLUSION: This study suggests that CLA reduced the adverse effects from 5-FU administration on the intestinal mucosa.
650 $aCytokines
653 $aBacterial translocation
653 $aConjugated linoleic acids
653 $aIntestinal damage
653 $aMucositis
653 $aTight junction protein
700 1 $aANDRADE, M. E. R.
700 1 $aGENEROSO, S. de V.
700 1 $aMIRANDA, S. E. M.
700 1 $aREIS, D. C. dos
700 1 $aLEOCÁDIO, P. C. L.
700 1 $aSOUZA, E. L. de S. e
700 1 $aMARTINS, F. dos S.
700 1 $aGAMA, M. A. S. da
700 1 $aCASSALI, G. D.
700 1 $aLEITE, J. I. A.
700 1 $aFERNANDES, S. O. A.
700 1 $aCARDOSO, V. N.
773 $tBiomedicine & Pharmacotherapy$gv. 103, p. 1567-1576, 2018.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Gado de Leite (CNPGL) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 16 | |
| 3. |  | MOREIRA, J. C. S.; OSORIO, E. A. Associação de caracteres morfológicos da planta de trigo com o rendimento de grãos. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA PARA O PROGRESSO DA CIÊNCIA, 29., 1977, São Paulo. Resumo... Ciência e Cultura, São Paulo, v. 29, n. 7, p. 706-707, 1977. S| Biblioteca(s): Embrapa Trigo. |
|   |
| 6. | | OSORIO, E. A.; BARCELLOS, A. L.; MOREIRA, J. C. S. Reações a campo de cultivares de trigo à ferrugem da folha. Pesquisa Agropecuária Brasileira, Série Agronomia, Brasília, DF, v. 11, n. 12, p. 15-18, 1976.| Biblioteca(s): Embrapa Trigo; Embrapa Unidades Centrais. |
|  |
| 11. | | LUZZARDI, G. C.; PIEROBOM, C. R.; OSORIO, E. A.; MOREIRA, J. C. S.; DIAS, J. C. A.; SOUZA, P. G. Reação de cultivares de trigo a giberela, em casa de vegetação, nos anos de 1971 a 1974. In: REUNIÃO ANUAL CONJUNTA DE PESQUISA DE TRIGO, 7., 1975, Passo Fundo. Súmula... Passo Fundo: EMBRAPA-CNPT, 1975. p. 44-45| Biblioteca(s): Embrapa Trigo. |
| |
| 12. | | LUZZARDI, G. C.; PIEROBON, C. R.; OSORIO, E. A.; MOREIRA, J. C. S.; WETZEL, M. M.; DIAS, J. C. A. Wheat reaction to Septoria nodorum (Berk.). Annual Wheat Newsletter, Fort Collins, v. 21, p. 52, May 1975.| Biblioteca(s): Embrapa Trigo. |
| |
| 13. | | MOREIRA, J. C.; LANGER, F. A.; DOTTO, S. R.; PAN, C. L.; MEDEIROS, M. C.; GOMES, E. P.; OSORIO, E. A.; IGNACZAK, J. C.; PERUZZO, G. Experimentação com trigo no IPEAS-RS. In: IPEAS - Estação Experimental de Passo Fundo. Trigo - experimentação. Passo Fundo, 1973. p. 1-49 Trabalho apresentado na V Reunião Anual Conjunta de Pesquisa de Trigo, Porto Alegre, 1973.| Biblioteca(s): Embrapa Trigo. |
| |
| 16. | | MOREIRA, J. C. S.; OSORIO, E. A.; MEDEIROS, M. C. C.; LANGER, F. A.; LINHARES, V. I.; GOMES, E. P.; SOUZA, C. N. A. de; COPPOLLA, G. C. Variedades. In: IPEAS. Cultura do trigo no Rio Grande do Sul e Santa Catarina. Pelotas, 1971. p. 19-29 (IPEAS. Circular, 48).| Biblioteca(s): Embrapa Trigo. |
| |
| Registros recuperados : 16 | |
|
| Expressão de busca inválida. Verifique!!! |
|
|
