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 | Acesso ao texto completo restrito à biblioteca da Embrapa Suínos e Aves. Para informações adicionais entre em contato com cnpsa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
22/03/2012 |
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Data da última atualização: |
22/03/2012 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ELLINGSON, J. S.; WANG, Y.; LAYTON, S.; ZANELLA, J. R. C.; ROOF, M. B.; FAABERG, K. S. |
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Afiliação: |
JOSHUA S. ELLINGSON, Iowa State University; YUE WANG, University of Minnesota; SARAH LAYTON, Boerhinger Ingelheim Vetmedica; JANICE REIS CIACCI ZANELLA, CNPSA; MICHAEL B. ROOF, Boehringer Ingelheim Vetmedica; KAY S. FAABERG, University of Minnesota. |
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Título: |
Vaccine efficacy of porcine reproductive and respiratory syndrome virus chimeras. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Vaccine, v. 28, n. 14, p. 2679-2686, 2010. |
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Idioma: |
Inglês |
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Notas: |
Projeto/Plano de Ação: 03.09.00.046. |
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Conteúdo: |
The vaccine efficacy of six PRRSV Type 2 infectious clones, including five chimeras and a strain-specific deletion mutant, were examined using a respiratory challenge model in growing swine. The chimeras were constructed from different combinations of a licensed modified live vaccine (Ingelvac® PRRS MLV) and a virulent field isola e (wt MN184) which differ by 14.3% on a nucleotide basis, while the deletion mutant tested had a broad deletion in the nsp2 region of strain MN184. The appearance of antibodies and virus characterization revealed regions of the genome that could influence PRRSV replication in vivo. Swine growth, clinical signs and lung lesions were also monitored. Average daily weight gain was negatively and directly impacted by some vaccines, and after challenge, vaccination with different constructs led to variable weight gain. We determined that 3 of the tested chimeras, including two previously published chimeras [1] and one in which strain MN184 ORF5-6 was placed on the background of Ingelvac® PRRS MLV were able to prevent lung consolidation to a similar extent as traditionally prepared cell-passaged attenuated vaccines. The study suggested that only specific chimeras can attenuate clinical signs in swine and that attenuation cannot be directly linked to primary virus replication. Additionally, the strain MN184 deletion mutant was not found to have been sufficiently attenuated nor efficacious against heterologous challenge with strain JA-142. |
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Thesagro: |
Suíno; Vacina; Vírus. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02125naa a2200229 a 4500
001 1919883
005 2012-03-22
008 2011 bl uuuu u00u1 u #d
100 1 $aELLINGSON, J. S.
245 $aVaccine efficacy of porcine reproductive and respiratory syndrome virus chimeras.$h[electronic resource]
260 $c2011
500 $aProjeto/Plano de Ação: 03.09.00.046.
520 $aThe vaccine efficacy of six PRRSV Type 2 infectious clones, including five chimeras and a strain-specific deletion mutant, were examined using a respiratory challenge model in growing swine. The chimeras were constructed from different combinations of a licensed modified live vaccine (Ingelvac® PRRS MLV) and a virulent field isola e (wt MN184) which differ by 14.3% on a nucleotide basis, while the deletion mutant tested had a broad deletion in the nsp2 region of strain MN184. The appearance of antibodies and virus characterization revealed regions of the genome that could influence PRRSV replication in vivo. Swine growth, clinical signs and lung lesions were also monitored. Average daily weight gain was negatively and directly impacted by some vaccines, and after challenge, vaccination with different constructs led to variable weight gain. We determined that 3 of the tested chimeras, including two previously published chimeras [1] and one in which strain MN184 ORF5-6 was placed on the background of Ingelvac® PRRS MLV were able to prevent lung consolidation to a similar extent as traditionally prepared cell-passaged attenuated vaccines. The study suggested that only specific chimeras can attenuate clinical signs in swine and that attenuation cannot be directly linked to primary virus replication. Additionally, the strain MN184 deletion mutant was not found to have been sufficiently attenuated nor efficacious against heterologous challenge with strain JA-142.
650 $aSuíno
650 $aVacina
650 $aVírus
700 1 $aWANG, Y.
700 1 $aLAYTON, S.
700 1 $aZANELLA, J. R. C.
700 1 $aROOF, M. B.
700 1 $aFAABERG, K. S.
773 $tVaccine$gv. 28, n. 14, p. 2679-2686, 2010.
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Registro original: |
Embrapa Suínos e Aves (CNPSA) |
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| Registros recuperados : 11 | |
| 3. |  | OLIVARES, C.; FONSECA, J. F. da; SARAIVA, H.; ALFRADIQUE, V.; CÔRTES, L.; COSTA, L.; BRANDÃO, F.; SOUZA-FABJAN, J. M. Influence of Mini-Percoll techniques on motility parameters of ram frozen-thawed sperm. In: INTERNATIONAL CONGRESS OF ANIMAL REPRODUCTION, 18., 2016, Tours. Abstracts... Tous: Society for Reprocutive Biololy, 2016. p. 168-169. Abstract PW171 Poster.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 5. | | OLIVARES, C. C. S.; FONSECA, J. F. da; CAMARGO, L. S. de A.; SOUZA FABJAN, J. M. G. de; RODRIGUES, A. L. R.; BRANDÃO, F. Z. Comparison of different methods of goat sperm selection and capacitation for optimization of assisted reproductive technologies. Small Ruminant Research, v. 127, p. 44-49, June, 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 6. | | BRANDÃO, F. Z.; LEITE, C. R.; FONSECA, J. F. da; FERNANDES, D. A. de M.; BALARO, M. F. A.; SARZEDAS, A. C.; OLIVARES, C. C. S. Dilatação cervical em ovelhas da raça santa inês induzida por misoprostol, ocitocina e estradiol para desenvolvimento de método não cirúrgico para coleta de embriões. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE TECNOLOGIA DE EMBRIÕES, 29., 2015, Gramado. Anais... [S.l.]: SBTE, 2015. p. 326.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 7. | | OLIVARES, C. C. S.; SOUZA-FABJAN, J. M. G.; PENEIRAS, A. B. V.; BALARO, M. F. A.; FREITAS, V. J. F.; FONSECA, J. F. da; BRANDÃO, F. Z. The influence of different methods of frozen-thawed ovine spermatozoa selection on sperm capacitation and viability after incubation. Animal Reproduction, v. 12, n. 3, p. 554, Jul./Sept. 2015. Proceedings of the 29th Annual Meeting of the Brazilian Embryo Technology Society (SBTE); Gramado, RS, Brazil, August 20 to 23, 2015. Abstracts.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 8. | | OLIVARES, C. C. S.; SOUZA-FABJAN, J. M. G. de; FONSECA, J. F. da; BALARO, M. F. A.; FREITAS, V. J. de F.; OLIVEIRA, R. V. de; BRANDÃO, F. Z. Comparison of different sperm selection techniques in ram frozen-thawed sperm. Acta Scientiae Veterinariae, v. 45, p. 1431, 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 9. | | SOUZA-FABJAN, J. M. G. de; OLIVARES, C. C. S.; VELTRI, A. B. P.; BALARO, M. F. A.; FREITAS, V. J. de F.; FONSECA, J. F. da; BRANDÃO, F. Z. Avaliação da longevidade espermática após o uso de diferentes métodos de seleção de espermatozóides ovinos congelados. In: CONGRESSO BRASILEIRO DE REPRODUÇÃO ANIMAL, 21., 2015, Belo Horizonte. Anais... Belo Horizonte: CBRA, 2015. p. 199.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 10. | | OLIVARES, C. C. S.; ALFRADIQUE, V. A. P.; SOUZA FABJAN, J. M. G.; FONSECA, J. F. da; SARAIVA, H. F. R. A.; CÔRTES, L. R.; COSTA, L. C. da; BRANDÃO, F. Z. Influence of mini-Percoll techniques in sperm capacitation and plasma membrane integrity of ram frozen-thawed sperm. Animal Reproduction, v. 13, n. 3, p. 552, Jul./Sept. 2016. Proceedings of the 30th Annual Meeting of the Brazilian Embryo Technology Society (SBTE); Foz do Iguaçu, PR, Brazil, August 25th to 27th, 2016, and 32nd Meeting of the European Embryo Transfer Association (AETE); Barcelona, Spain,...| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 11. | | ALFRADIQUE, V. A. P.; OLIVARES, C. C. S.; SOUZA-FABJAN, J. M. G. de; FONSECA, J. F. da; BATISTA, R. I. T. P.; BALARO, M. F. A.; SARAIVA, H. F. R. de A.; CÔRTES, L. R.; BRANDÃO, F. Z. Mini-percoll technique induces Similar capacitation features in domestic ruminant frozen-thawed spermatozoa regardless of the presence of heparin. Acta Scientiae Veterinariae, v. 47, Pub. 1707, p. 1-8, 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| Registros recuperados : 11 | |
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