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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Ocidental. Para informações adicionais entre em contato com cpaa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
13/07/2006 |
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Data da última atualização: |
06/01/2015 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
FUKUMASU, H.; SILVA, T. C. da; AVANZO, J. L.; LIMA, C. E. de; MACKOWIAK, I. I.; ATROCH, A.; SPINOSA, H. de S.; MORENO, F. S.; DAGLI, M. L. Z. |
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Afiliação: |
Heidge Fukumasu, USP; Tereza Cristina da Silva, USP; José Luis Avanzo, USP; Cyntia Esteves de Lima, USP; Ivone Isabel Mackowiak, USP; André Atroch, CPAA; Helenice de Souza Spinosa, USP; Fernando Salvador Moreno, USP; Maria Lucia Zaidan Dagli, USP. |
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Título: |
Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guarana, on mouse hepatocarcinogenesis. |
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Ano de publicação: |
2006 |
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Fonte/Imprenta: |
Cancer Letters, v. 233, n. 1, p. 158-164, fev. 2006. |
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Idioma: |
Inglês |
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Conteúdo: |
Guarana (Paullinia cupana) is originally front Amazon, Brazil. Its effects on mouse hepatocarcinogenesis have been investigated in this study. Mice were treated with N-nitrosodiethylamine (DEN), received three different doses of P. cupana added to commercial food, and euthanized after 25 weeks. Gross lesions were quantified, and preneoplastic lesions (PNL) were histologically measured. Cellular proliferation was evaluated by immunobloting for the proliferating cell nuclear antigen (PCNA). The incidence and multiplicity of macroscopic lesions were reduced. The PNL number and PCNA expression were reduced in the highest P. cupana dose. According to these results, guarana presented inhibitory effects on DEN hepatocarcinogenesis in mice. |
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Palavras-Chave: |
Prevenção. |
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Thesagro: |
Cafeína; Câncer; Carcinôgeno; Fígado; Guaraná; Paullinia Cupana. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01561naa a2200301 a 4500
001 1678453
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008 2006 bl uuuu u00u1 u #d
100 1 $aFUKUMASU, H.
245 $aChemopreventive effects of Paullinia cupana Mart var. sorbilis, the guarana, on mouse hepatocarcinogenesis.
260 $c2006
520 $aGuarana (Paullinia cupana) is originally front Amazon, Brazil. Its effects on mouse hepatocarcinogenesis have been investigated in this study. Mice were treated with N-nitrosodiethylamine (DEN), received three different doses of P. cupana added to commercial food, and euthanized after 25 weeks. Gross lesions were quantified, and preneoplastic lesions (PNL) were histologically measured. Cellular proliferation was evaluated by immunobloting for the proliferating cell nuclear antigen (PCNA). The incidence and multiplicity of macroscopic lesions were reduced. The PNL number and PCNA expression were reduced in the highest P. cupana dose. According to these results, guarana presented inhibitory effects on DEN hepatocarcinogenesis in mice.
650 $aCafeína
650 $aCâncer
650 $aCarcinôgeno
650 $aFígado
650 $aGuaraná
650 $aPaullinia Cupana
653 $aPrevenção
700 1 $aSILVA, T. C. da
700 1 $aAVANZO, J. L.
700 1 $aLIMA, C. E. de
700 1 $aMACKOWIAK, I. I.
700 1 $aATROCH, A.
700 1 $aSPINOSA, H. de S.
700 1 $aMORENO, F. S.
700 1 $aDAGLI, M. L. Z.
773 $tCancer Letters$gv. 233, n. 1, p. 158-164, fev. 2006.
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