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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Oriental. Para informações adicionais entre em contato com cpatu.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
20/03/2025 |
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Data da última atualização: |
20/03/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
NUNES, J. de A.; TEIXEIRA, L. L.; NASCIMENTO, W. M. O. do; LOPES, D. C. F.; SILVA, J. K. R. da; PINTO, L. C.; SANTOS, P. V. L.; FIGUEIREDO, P. F. B. |
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Afiliação: |
JENNIFER DE A. NUNES, UNIVERSIDADE DO ESTADO DO PARÁ; LEONAN L. TEIXEIRA, UNIVERSIDADE FEDERAL DO PARÁ; WALNICE MARIA O DO NASCIMENTO, CPATU; DIELLY C. F. LOPES, UNIVERSIDADE FEDERAL DO PARÁ; JOYCE KELLY R. DA SILVA, UNIVERSIDADE FEDERAL DO PARÁ; LAINE C. PINTO, UNIVERSIDADE FEDERAL DO PARÁ; PAULO VINICIUS L. SANTOS, UNIVERSIDADE DO ESTADO DO PARÁ; PABLO LUIS B. FIGUEIREDO, UNIVERSIDADE DO ESTADO DO PARÁ. |
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Título: |
Seasonal variation on chemical composition and in vitro cytotoxic and anti-inflammatory activities of Myrciaria dubia (Kunth) McVaugh essential oil from Amazon. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
Biochemical Systematics and Ecology, v. 121, 105001, Aug. 2025. |
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DOI: |
https://doi.org/10.1016/j.bse.2025.105001 |
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Idioma: |
Inglês |
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Conteúdo: |
Myrciaria dubia (Kunth) McVaugh is a fruit tree native to the Amazon, commonly known as camu-camu. This species has applications in traditional medicine, pharmaceuticals, and cosmetics due to its high content of phenolic compounds, such as anthocyanins and tannins in its fruits, which have antioxidant and anti-inflammatory properties. This work aims to evaluate the influence of seasonality on chemical composition, and in vitro cytotoxicity and anti-inflammatory activities of M. dubia essential oil. Botanical material was collected monthly, the leaf essential oils were extracted by hydrodistillation, and the fruits were subjected to simultaneous distillation-extraction. GC and GC-MS performed chemical analyses of the essential oils and volatile concentrates. The local climatic parameters insolation, temperature, relative humidity, and precipitation were monitored. The MTT assay was performed to evaluate cell viability. Subsequently, a nitrite standard curve was performed to determine the nitrite concentration in the samples. The oils were tested for cytotoxic activity against gastric ascites (AGP01), glioblastoma (AHOL), and lung cancer (A549) cell lines, as well as against non-malignant murine macrophages (RAW 264.7). The essential oil yield ranged from 0.4% (April/2024) to 0.9% (October/2023), with an annual average of 0.7 ± 0.1%. There were no significant differences in the yields of the dry and rainy periods. The leaf essential oils constituents were characterized by α-pinene (0.28–49.13%), (E)-caryophyllene (12.1–34.31%), caryophyllene oxide (4.03–17.08%), leptospermone (3.88–7.92%), and δ-cadinene (1.78–6.67%). The main compounds of fruit volatile concentrates were α-pinene (25.1–55.5%), α-terpineol (7.88–21.08%), limonene (6.43–16.79%), and (E)-caryophyllene (3.44–8.67%). The essential oils treatment of M. dubia seasonal study showed significant variations in the nitrite concentration, highlighting the oil's anti-inflammatory effect. The cytotoxic activity showed antiproliferative activity against cancer cell lines AGP01, AHOL, and A549, as well as non-malignant RAW 264.7. These results reinforce the value of M. dubia as a promising source for developing pharmaceutical ingredients, especially in combating inflammatory processes and cell therapy of tumor cell lines. MenosMyrciaria dubia (Kunth) McVaugh is a fruit tree native to the Amazon, commonly known as camu-camu. This species has applications in traditional medicine, pharmaceuticals, and cosmetics due to its high content of phenolic compounds, such as anthocyanins and tannins in its fruits, which have antioxidant and anti-inflammatory properties. This work aims to evaluate the influence of seasonality on chemical composition, and in vitro cytotoxicity and anti-inflammatory activities of M. dubia essential oil. Botanical material was collected monthly, the leaf essential oils were extracted by hydrodistillation, and the fruits were subjected to simultaneous distillation-extraction. GC and GC-MS performed chemical analyses of the essential oils and volatile concentrates. The local climatic parameters insolation, temperature, relative humidity, and precipitation were monitored. The MTT assay was performed to evaluate cell viability. Subsequently, a nitrite standard curve was performed to determine the nitrite concentration in the samples. The oils were tested for cytotoxic activity against gastric ascites (AGP01), glioblastoma (AHOL), and lung cancer (A549) cell lines, as well as against non-malignant murine macrophages (RAW 264.7). The essential oil yield ranged from 0.4% (April/2024) to 0.9% (October/2023), with an annual average of 0.7 ± 0.1%. There were no significant differences in the yields of the dry and rainy periods. The leaf essential oils constituents were characterized by α-pi... Mostrar Tudo |
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Thesagro: |
Camu Camu; Câncer; Composição Química; Myrciaria Dubia; Myrtaceae; Óleo Essencial; Variação Sazonal. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 03320naa a2200301 a 4500
001 2174104
005 2025-03-20
008 2025 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.bse.2025.105001$2DOI
100 1 $aNUNES, J. de A.
245 $aSeasonal variation on chemical composition and in vitro cytotoxic and anti-inflammatory activities of Myrciaria dubia (Kunth) McVaugh essential oil from Amazon.$h[electronic resource]
260 $c2025
520 $aMyrciaria dubia (Kunth) McVaugh is a fruit tree native to the Amazon, commonly known as camu-camu. This species has applications in traditional medicine, pharmaceuticals, and cosmetics due to its high content of phenolic compounds, such as anthocyanins and tannins in its fruits, which have antioxidant and anti-inflammatory properties. This work aims to evaluate the influence of seasonality on chemical composition, and in vitro cytotoxicity and anti-inflammatory activities of M. dubia essential oil. Botanical material was collected monthly, the leaf essential oils were extracted by hydrodistillation, and the fruits were subjected to simultaneous distillation-extraction. GC and GC-MS performed chemical analyses of the essential oils and volatile concentrates. The local climatic parameters insolation, temperature, relative humidity, and precipitation were monitored. The MTT assay was performed to evaluate cell viability. Subsequently, a nitrite standard curve was performed to determine the nitrite concentration in the samples. The oils were tested for cytotoxic activity against gastric ascites (AGP01), glioblastoma (AHOL), and lung cancer (A549) cell lines, as well as against non-malignant murine macrophages (RAW 264.7). The essential oil yield ranged from 0.4% (April/2024) to 0.9% (October/2023), with an annual average of 0.7 ± 0.1%. There were no significant differences in the yields of the dry and rainy periods. The leaf essential oils constituents were characterized by α-pinene (0.28–49.13%), (E)-caryophyllene (12.1–34.31%), caryophyllene oxide (4.03–17.08%), leptospermone (3.88–7.92%), and δ-cadinene (1.78–6.67%). The main compounds of fruit volatile concentrates were α-pinene (25.1–55.5%), α-terpineol (7.88–21.08%), limonene (6.43–16.79%), and (E)-caryophyllene (3.44–8.67%). The essential oils treatment of M. dubia seasonal study showed significant variations in the nitrite concentration, highlighting the oil's anti-inflammatory effect. The cytotoxic activity showed antiproliferative activity against cancer cell lines AGP01, AHOL, and A549, as well as non-malignant RAW 264.7. These results reinforce the value of M. dubia as a promising source for developing pharmaceutical ingredients, especially in combating inflammatory processes and cell therapy of tumor cell lines.
650 $aCamu Camu
650 $aCâncer
650 $aComposição Química
650 $aMyrciaria Dubia
650 $aMyrtaceae
650 $aÓleo Essencial
650 $aVariação Sazonal
700 1 $aTEIXEIRA, L. L.
700 1 $aNASCIMENTO, W. M. O. do
700 1 $aLOPES, D. C. F.
700 1 $aSILVA, J. K. R. da
700 1 $aPINTO, L. C.
700 1 $aSANTOS, P. V. L.
700 1 $aFIGUEIREDO, P. F. B.
773 $tBiochemical Systematics and Ecology$gv. 121, 105001, Aug. 2025.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
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| Registros recuperados : 17 | |
| 2. |  | PADILHA, A. C.; PIOVESAN, B.; MORAIS, M. C.; ZOTTI, M.; BOTTON, M.; GRÜTZMACHER, A. D. Efeito de inseticidas na atividade locomotora de Plebeia emerina (Hymenoptera: Apidae). In: CONGRESSO BRASILEIRO DE ENTOMOLOGIA, 27.; CONGRESSO LATINO-AMERICANO DE ENTOMOLOGIA, 10., 2018, Gramado, RS. Saúde, ambiente e agricultura: anais. Santo Antonio de Goiás: SEB: UFSM, 2018. v. 2. resumo. p. 1295.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Uva e Vinho. |
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| 4. | | MORAIS, M. C.; RAKES, M.; PADILHA, A. C.; GRÜTZMACHER, A. D.; NAVA, D. E.; BERNARDI, O.; BERNARDI, D. Susceptibility of Brazilian Populations of Anastrepha fraterculus, Ceratitis capitata (Diptera: Tephritidae), and Drosophila suzukii (Diptera: Drosophilidae) to Selected Insecticides. Journal of Economic Entomology, v. 114, n. 3, p. 1291-1297, 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Clima Temperado. |
|  |
| 5. | | VIEIRA, J. G. A.; KRÜGER, A. P.; SCHEUNEUMANN, T.; GARCEZ, A. M.; MORAIS, M. C.; GARCIA, F. R. M.; NAVA, D. E.; BERNARDI, D. Effect of temperature on the development time and life time fecundity of parasitizing. Journal of Applied Entomology, v. 144, n. 10, p. 857-865, Dec. 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 6. | | KRÜGER, A. P.; SCHEUNEMANN, T.; VIEIRA, J. G. A.; MORAIS, M. C.; BERNARDI, D.; NAVA, D. E.; GARCIA, F. R. M. Effects of Extrinsic, Intraspecific Competition and Host Deprivation on the Biology of Trichopria anastrephae (Hymenoptera: Diapriidae) Reared on Drosophila suzukii (Diptera: Drosophilidae). Neotropical Entomology, v. 48, p. 957-965, 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 8. | | RIBEIRO, E. P.; PAES, M. C. D.; TEIXEIRA, F. F.; BARBOSA, N. A.; MOURA, P. L. T. de; MORAIS, M. C. B. de. Atividade antioxidante de milho verde de grãos pretos. In: CONGRESSO NACIONAL DE MILHO E SORGO, 30.; SIMPÓSIO SOBRE LEPDÓPTEROS COMUNS A MILHO, SOJA E ALGODÃO, 1., 2014, Salvador. Eficiência nas cadeias produtivas e o abastecimento global: resumos expandidos. Sete Lagoas: Associação Brasileira de Milho e Sorgo, 2014. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 9. | | MORAIS, M. C. C.; ARRAIS, A. M.; SILVA, N. C.; OLIVEIRA, M. E. F.; SOUZA-FABJAN, J. M. G.; FONSECA, J. F. da. Association of controlled light program, cloprostenol and gonadotropins for synchronous estrus induction and fixed time artificial insemination in dairy goats during the non-breeding season: preliminary results. Animal Reproduction, v. 17, n. 3, 2020. Edição dos Abstracts of the 34nd Annual Meeting of the Brazilian Embryo Technology Society (SBTE), 2020 (online).| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 10. | | LAUMANN, R. A.; RIBEIRO, P. H.; RAMOS, N.; PIRES, C. S. S; SCHMIDT, F. G. V.; BORGES, M.; MORAIS, M. C. B.; SUJII, E. R. Ritmos diários de atividades comportamentais de Diabrotica speciosa (Germar, 1824) Coleoptera: Chrysomelidae) relacionados à temperatura. Brasília, DF: Embrapa Recursos Genéticos e Biotecnologia, 2003. 6 p. (Embrapa Recursos Genéticos e Biotecnologia. Comunicado técnico, 90).| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 11. | | BRAIR, V. L.; ANDRADE, A. B. P.; MORAIS, M. C. C.; RANGEL, P. S. C.; OLIVEIRA, M. E. F.; SOUZA-FABJAN, J. M. G.; FONSECA, J. F. da. Short-term hormonal protocol efficiency either with or without equine chorionic gonadotrophin to promote oestrous synchronization in cyclic dairy goats. Reproduction, Fertility and Development, v. 33, n. 1/2, p. 165, 2021. Edição dos Proceedings of the 47th Annual Conference of the International Embryo Technology (IETS) Virtual Meeting, January 18-21, 2021.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 12. | | VIEIRA, J. G. A.; KRÜGER, A. P.; SCHEUNEUMANN, T.; MORAIS, M. C.; SPERIOGIN, H. J.; GARCIA, F. R. M.; NAVA, D. E.; BERNARDI, D. Some aspects of the biology of Trichopria anastrephae (Hymenoptera: Diapriidae), a resident parasitoid attacking Drosophila suzukii (Diptera: Drosophilidae) in Brazil. Journal of Economic Entomology, v. 113, n. 1, p. 81-87, 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 13. | | ANDRADE, A. B. P. de; MORAIS, M. C. C.; RANGELM P. S. C.; OLIVEIRA, M. E. F.; SOUZA-FABJAN, J. M. G.; FONSECA, J. F. da. Effect of eCG in a short-term synchronization treatment on ovarian status, estrus synchrony, and ovulation in dairy goats managed under tropical conditions. Tropical Animal Health and Production, v. 53, n. 246, 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 14. | | FIGUEIRA, L. M.; ALVES, N. G.; MAIA, A. L. R. e S.; SOUZA-FABJAN, J. M. de; BATISTA, R. I. T. P.; MORAIS, M. C. da C.; LIMA, R. R. de; OLIVEIRA, M. E. F.; FONSECA, J. F. da. Embryo yield and quality are associated with progestogen treatment during superovulation protocol in lactating Lacaune ewes. Theriogenology, v. 155, p. 132-138, Oct. 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 15. | | SANTOS, J. D. R.; OLIVEIRA, I. C.; BRAIR, V. L.; BALARO, M. F. A.; MORAIS, M. C. C.; ARASHIRO, E. K. N.; SOUZA-FABJAN, J. M. G.; FONSECA, J. F. da; BRANDÃO, F. Z. Comparison of stress and animal welfare caused by the procedures of embryo collection by either surgical or non-surgical via in sheep. Animal Reprodroduction, v. 15, n. 3, p. 404, Jul./Sept. 2018. Abstract A091. Edição dos Proceedings of the 32nd Annual Meeting of the Brazilian Embryo Technology Society (SBTE); Florianópolis, SC, Brazil, August 16th to 18th, 2018.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 16. | | SOUZA-FABJAN, J. M. G.; FIGUEIRA, L. M.; ALVES, N. G.; BATISTA, R. I. T. P.; SOUZA, L. C.; ARRAIS, A. A.; SILVA, C. F.; MORAIS, M. C. C.; FONSECA, J. F. da. Transcervical embryo recovery in Lacaune ewes superovulated with different doses of FSH. Animal Reprodroduction, v. 15, n. 3, p. 363, Jul./Sept. 2018. Abstracts A136E. Edição dos Proceedings of the 34rd Meeting of the Association of Embryo Transfer in Europe (AETE); Nantes, France, September 7th and 8th, 2018.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 17. | | VERGANI, G. B.; ARRAIS, A. M.; MELLO, M. R. B. de; DIAS, J. H.; SOUSA, M. A. P. de; MORAIS, M. C. da C.; FERREIRA, H. C.; BEVILAQUA, J. R.; OLIVEIRA, M. E. F.; SOUZA-FABJAN, J. M. G.; FONSECA, J. F. da. Follicular population at the beginning of pFSH treatment in Morada Nova ewes submitted to estrous synchronization protocols by short- (6 days), medium- (9 days) or long-term (12 days). Revista Brasileira de Reprodução Animal, v. 43, n. 2, p. 533, abr./jun. 2019. Edição dos resumos do XXIII Congresso Brasileiro de Reprodução Animal, Gramado, RS, Brasil, 15 a 17 de maio 2019.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| Registros recuperados : 17 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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