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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria de Alimentos. Para informações adicionais entre em contato com ctaa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
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Data corrente: |
02/12/2016 |
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Data da última atualização: |
25/09/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
TONUCCI, L. B.; SANTOS, K. M. O. dos; OLIVEIRA, L. L. de; RIBEIRO, S. M. R.; MARTINO, H. S. D. |
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Afiliação: |
Livia Bordalo Tonucci, INTA; KARINA MARIA OLBRICH DOS SANTOS, CTAA; Leandro Licursi de Oliveira, UFV; Sonia Machado Rocha Ribeiro, UFV; Hercia Stampini Duarte Martino, UFV. |
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Título: |
Clinical application of probiotics in type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Clinical Nutrition, v. 36, n. 1, p. 85-92, 2017. |
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DOI: |
10.1016/j.clnu.2015.11.011. |
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Idioma: |
Inglês |
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Conteúdo: |
Background & aims: Type 2 diabetes has been associated with dysbiosis and one of the possible routes to restore a healthy gut microbiota is by the regular ingestion of probiotics. We aimed to investigate the effects of probiotics on glycemic control, lipid profile, inflammation, oxidative stress and short chain fatty acids in T2D. Methods: In a double-blind, randomized, placebo-controlled trial, 50 volunteers consumed daily 120 g/d of fermented milk for 6 wk. Participants were assigned into two groups: probiotic group, consuming fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp lactis BB-12 (109 colony-forming units/d, each) and control group, consuming conventional fermented milk. Anthropometric measurements, body composition, fasting blood and faecal samples were taken at baseline and after 6 wk. Results: 45 subjects out of 50 (90%) completed follow-up. After 6 wk, there was a significant decrease in fructosamine levels (9.91 mmol/L; p ¼ 0.04) and hemoglobin A1c tended to be lower (0.67%; p ¼ 0.06) in probiotic group. TNF-a and resistin were significantly reduced in probiotic and control groups (1.5 and 1.3 pg/mL, .1 and 2.8 ng/mL, respectively), while IL-10 was significantly reduced ( 0.65 pg/mL; p < 0.001) only in the control group. Fecal acetic acid was increased in both groups (0.58 and 0.59% in probiotic and control groups, respectively; p < 0.01). There was a significant difference between groups concerning mean changes of HbA1c (þ0.31 for control group vs 0.65 for probiotic group; p ¼ 0.02), total cholesterol (þ0.55 for control group vs 0.15 for probiotic group; p ¼ 0.04) and LDL-cholesterol (þ0.36 for control group vs 0.20 for probiotic group p ¼ 0.03). Conclusions: Probiotic consumption improved the glycemic control in T2D subjects, however, the intake of fermented milk seems to be involved with others metabolic changes, such as decrease in inflammatory cytokines (TNF-a and resistin) and increase in the acetic acid. MenosBackground & aims: Type 2 diabetes has been associated with dysbiosis and one of the possible routes to restore a healthy gut microbiota is by the regular ingestion of probiotics. We aimed to investigate the effects of probiotics on glycemic control, lipid profile, inflammation, oxidative stress and short chain fatty acids in T2D. Methods: In a double-blind, randomized, placebo-controlled trial, 50 volunteers consumed daily 120 g/d of fermented milk for 6 wk. Participants were assigned into two groups: probiotic group, consuming fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp lactis BB-12 (109 colony-forming units/d, each) and control group, consuming conventional fermented milk. Anthropometric measurements, body composition, fasting blood and faecal samples were taken at baseline and after 6 wk. Results: 45 subjects out of 50 (90%) completed follow-up. After 6 wk, there was a significant decrease in fructosamine levels (9.91 mmol/L; p ¼ 0.04) and hemoglobin A1c tended to be lower (0.67%; p ¼ 0.06) in probiotic group. TNF-a and resistin were significantly reduced in probiotic and control groups (1.5 and 1.3 pg/mL, .1 and 2.8 ng/mL, respectively), while IL-10 was significantly reduced ( 0.65 pg/mL; p < 0.001) only in the control group. Fecal acetic acid was increased in both groups (0.58 and 0.59% in probiotic and control groups, respectively; p < 0.01). There was a significant difference between groups concerning mean changes of Hb... Mostrar Tudo |
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Palavras-Chave: |
Gut microbiota; Oxidative; Type 2 diabetes. |
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Thesagro: |
Stress. |
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Thesaurus Nal: |
Inflammation; Probiotics. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 02784naa a2200253 a 4500
001 2057801
005 2017-09-25
008 2017 bl uuuu u00u1 u #d
024 7 $a10.1016/j.clnu.2015.11.011.$2DOI
100 1 $aTONUCCI, L. B.
245 $aClinical application of probiotics in type 2 diabetes mellitus$ba randomized, double-blind, placebo-controlled study.$h[electronic resource]
260 $c2017
520 $aBackground & aims: Type 2 diabetes has been associated with dysbiosis and one of the possible routes to restore a healthy gut microbiota is by the regular ingestion of probiotics. We aimed to investigate the effects of probiotics on glycemic control, lipid profile, inflammation, oxidative stress and short chain fatty acids in T2D. Methods: In a double-blind, randomized, placebo-controlled trial, 50 volunteers consumed daily 120 g/d of fermented milk for 6 wk. Participants were assigned into two groups: probiotic group, consuming fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp lactis BB-12 (109 colony-forming units/d, each) and control group, consuming conventional fermented milk. Anthropometric measurements, body composition, fasting blood and faecal samples were taken at baseline and after 6 wk. Results: 45 subjects out of 50 (90%) completed follow-up. After 6 wk, there was a significant decrease in fructosamine levels (9.91 mmol/L; p ¼ 0.04) and hemoglobin A1c tended to be lower (0.67%; p ¼ 0.06) in probiotic group. TNF-a and resistin were significantly reduced in probiotic and control groups (1.5 and 1.3 pg/mL, .1 and 2.8 ng/mL, respectively), while IL-10 was significantly reduced ( 0.65 pg/mL; p < 0.001) only in the control group. Fecal acetic acid was increased in both groups (0.58 and 0.59% in probiotic and control groups, respectively; p < 0.01). There was a significant difference between groups concerning mean changes of HbA1c (þ0.31 for control group vs 0.65 for probiotic group; p ¼ 0.02), total cholesterol (þ0.55 for control group vs 0.15 for probiotic group; p ¼ 0.04) and LDL-cholesterol (þ0.36 for control group vs 0.20 for probiotic group p ¼ 0.03). Conclusions: Probiotic consumption improved the glycemic control in T2D subjects, however, the intake of fermented milk seems to be involved with others metabolic changes, such as decrease in inflammatory cytokines (TNF-a and resistin) and increase in the acetic acid.
650 $aInflammation
650 $aProbiotics
650 $aStress
653 $aGut microbiota
653 $aOxidative
653 $aType 2 diabetes
700 1 $aSANTOS, K. M. O. dos
700 1 $aOLIVEIRA, L. L. de
700 1 $aRIBEIRO, S. M. R.
700 1 $aMARTINO, H. S. D.
773 $tClinical Nutrition$gv. 36, n. 1, p. 85-92, 2017.
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Registro original: |
Embrapa Agroindústria de Alimentos (CTAA) |
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Biblioteca |
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| Registros recuperados : 46 | |
| 4. |  | CHAGAS, E. C.; PILARSKI, F.; SAKABE, R.; MORAES, F. R. de. Desempenho produtivo e respostas fisiopatológicas de tambaquis alimentados com ração suplementada com b-glucano. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 48, n. 8, p. 899-905, ago. 2013.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Amazônia Ocidental; Embrapa Unidades Centrais. |
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| 7. | | FUJIMOTO, R. Y.; CASTRO, M. P. de; HONORATO, C. A.; MORAES, F. R. de. Composição corporal e eficiência de utilização de nutrientes por pacus alimentados com ração suplementada com cromo trivalente. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 42, n. 12, p. 1763-1768, dez. 2007 Título em inglês: Body composition and nutrient efficiency use by pacus fed on ration supplemented with chromium.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 12. | | SALIM, J. A.; MAZONI, I.; MANCINI, A. L.; MORAES, F. R.; JARDINE, J. G.; NESHICH, I. P.; NESHICH, G. MSSP: a web-based application for analysis of selected parameter from multiple structures in a graphical manner. In: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 5., 2009, Angra dos Reis. Abstracts book... Angra dos Reis: ABBCB, 2009. Não paginado. X-Meeting 2009.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 14. | | NESHICH, I. A. P.; MORAES, F. R. de; SALIM, J. A.; MAZONI, I.; MANCINI, A.; JARDINE, J. G.; NESHICH, G. Surface hydrophobicity index (SHI): insight into the mechanisms of protein-protein associations. In: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 5., 2009, Angra dos Reis. Abstracts book... Angra dos Reis: ABBCB, 2009. Não paginado. X-Meeting 2009| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 15. | | MAZONI, I.; SALIM, J. A; NESHICH, I. A. P.; MORAES, F. R. de; NISHIMURA, L.; JARDINE, J. G.; NESHICH, G. Structure function relationship de convoluted to a level of physical chemical descriptors: case study - lysozyme / lactalbumine differences. In: ANNUAL MEETING OF THE SBBq, 40., 2011, Foz do Iguaçu. [Proceedings...]. São Paulo, SP: Brazilian Society for Biochemistry and Molecular Biology, 2011. Não paginado.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 17. | | MAZONI, I.; SALIM, J. A; MORAES, F. R. de; CORREA, J. L.; BORRO, L. C.; NESHICH, G. Comprehensive analysis of the distinct nano environments characteristics containing the different secondary structure elements: alpha-helices, beta-sheets, and turns. Current Nanomedicine, v. 15, n. 3, p. 267-285, 2025.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 18. | | JARDINE, J. G.; NESHICH, I. A. P.; MORAES, F. R. de; MAZONI, I.; MANCINI, A.; SALIM, J. A.; NESHICH, G. Generation of lipase B mutants with increased surface hydrophobicity in order to improve biodiesel catalysis. In: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 5., 2009, Angra dos Reis. Abstracts book... Angra dos Reis: ABBCB, 2009. Não paginado. X-Meeting 2009.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 19. | | SAKABE, R.; MORAES, F. R. de; BELO, M. A. de A.; PILARSKI, F.; MORAES, J. R. E. de. Kinetics of chronic inflammation in Nile tilapia fed n-3 and n-6 essential fatty acids. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 48, n. 3, p. 313-319, mar. 2013. Título em português: Cinética da inflamação crônica em tilápia?do?nilo alimentada com ácidos graxos essenciais n?3 e n?6.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 20. | | VARANDAS, D. N; MARTINS, M. L; MORAES, F. R. de; RAMOS, F. M.; SANTOS, R. F. B.; FUJIMOTO, R. Y. Pesque-solte: pesca repetitiva, variáveis hematológicas e parasitismo no peixe híbrido tambacu. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 48, n. 8, p. 1058-1063, ago. 2013.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Tabuleiros Costeiros; Embrapa Unidades Centrais. |
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| Registros recuperados : 46 | |
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