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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
16/11/2020 |
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Data da última atualização: |
10/08/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
TOSCANO, J. H. B.; OKINO, C. H.; SANTOS, I. B. dos; GIRALDELO, L. A.; HAEHLING, M. B. von; ESTEVES, S. N.; BASSETTO, C. C.; AMARANTE, A. F. T. do; CHAGAS, A. C. de S. |
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Afiliação: |
João Henrique Barbosa Toscano, UNESP; CINTIA HIROMI OKINO, CPPSE; Isabella Barbosa dos Santos, UNESP; Luciana Aparecida Giraldelo, UNICEP; Marei Borsch von Haehling, UNESP; SERGIO NOVITA ESTEVES, CPPSE; Cesar Cristiano Bassetto, UNESP; Alessandro Francisco Talamini do Amarante, UNESP; ANA CAROLINA DE SOUZA CHAGAS, CPPSE. |
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Título: |
Local and systemic immune mediators of Morada Nova lambs with divergent Haemonchus contortus resistance phenotypes. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Parasite Immunology, v. 42, e12790, 2020. |
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Páginas: |
10 p. |
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DOI: |
https://doi.org/10.1111/pim.12790 |
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Idioma: |
Inglês |
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Conteúdo: |
Aims: Local and systemic immune mediators of Morada Nova lambs with divergent Haemonchus contortus resistance phenotypes were evaluated. Methods and Results: Lambs were ranked through faecal egg counts (FEC) after two parasitic challenges with 4,000 H.contortus L3. After the second challenge, the lambs underwent a third artificial infection and were euthanized 7 days later. Immunerelated genes were quantified locally in abomasal mucosa and lymph nodes (CD4, IFN?, IL4, IL5, IL13, IL2RA and MS4A2) and systemically in the whole blood (IL4 and IL13). Anti-H. contortus IgG and IgA antibodies and eosinophils and mast cells counts were also investigated. Resistant animals presented higher systemic IgG and IgA titres, both negatively correlated with FEC. Susceptible animals had higher blood levels of IL4 transcripts. At the local level, resistant lambs had higher eosinophils counts and superior MS4A2 levels in abomasal fundic mucosa, besides higher IgA levels in abomasal mucus, while susceptible lamb had superior IL4 expression in abomasal lymph nodes. Conclusion: These data indicate that resistant lambs had an immune response mediated by antibody-mediated cytotoxicity. Also, the systemic humoral profile, particularly IgA isotype, seems to be a good resistance marker for Morada Nova sheep, as we found differences between groups even when FEC did not differ. |
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Palavras-Chave: |
Host resistance; Morada Nova. |
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Thesagro: |
Elisa; Haemonchus Contortus. |
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Thesaurus Nal: |
Eosinophils; Gene expression; Sheep breeds. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02332naa a2200325 a 4500
001 2126621
005 2022-08-10
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1111/pim.12790$2DOI
100 1 $aTOSCANO, J. H. B.
245 $aLocal and systemic immune mediators of Morada Nova lambs with divergent Haemonchus contortus resistance phenotypes.$h[electronic resource]
260 $c2020
300 $a10 p.
520 $aAims: Local and systemic immune mediators of Morada Nova lambs with divergent Haemonchus contortus resistance phenotypes were evaluated. Methods and Results: Lambs were ranked through faecal egg counts (FEC) after two parasitic challenges with 4,000 H.contortus L3. After the second challenge, the lambs underwent a third artificial infection and were euthanized 7 days later. Immunerelated genes were quantified locally in abomasal mucosa and lymph nodes (CD4, IFN?, IL4, IL5, IL13, IL2RA and MS4A2) and systemically in the whole blood (IL4 and IL13). Anti-H. contortus IgG and IgA antibodies and eosinophils and mast cells counts were also investigated. Resistant animals presented higher systemic IgG and IgA titres, both negatively correlated with FEC. Susceptible animals had higher blood levels of IL4 transcripts. At the local level, resistant lambs had higher eosinophils counts and superior MS4A2 levels in abomasal fundic mucosa, besides higher IgA levels in abomasal mucus, while susceptible lamb had superior IL4 expression in abomasal lymph nodes. Conclusion: These data indicate that resistant lambs had an immune response mediated by antibody-mediated cytotoxicity. Also, the systemic humoral profile, particularly IgA isotype, seems to be a good resistance marker for Morada Nova sheep, as we found differences between groups even when FEC did not differ.
650 $aEosinophils
650 $aGene expression
650 $aSheep breeds
650 $aElisa
650 $aHaemonchus Contortus
653 $aHost resistance
653 $aMorada Nova
700 1 $aOKINO, C. H.
700 1 $aSANTOS, I. B. dos
700 1 $aGIRALDELO, L. A.
700 1 $aHAEHLING, M. B. von
700 1 $aESTEVES, S. N.
700 1 $aBASSETTO, C. C.
700 1 $aAMARANTE, A. F. T. do
700 1 $aCHAGAS, A. C. de S.
773 $tParasite Immunology$gv. 42, e12790, 2020.
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| 1. |  | FONSECA, C. F. da; LIMA, D. C. V. de; SOUZA, D. da S. e; SILVA, S. G. N. da; LIMA, J. R. B. de; OLIVEIRA, J. B. de; MOURA, G. J. B. de; ALÉSSIO, F. M. Distribuição espacial e abundância de carrapatos (Acari: Ixodidae) em remanescente de Mata Atlântica, Nordeste do Brasil. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n, 10, p. 1085-1090, outubro 2017. Título em inglês: Spatial distribution and abundance of ticks (Acari: Ixodidae) in Atlantic forest remaining, northeastern Brazil.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 2. | | LEAL, C. A. S.; KIM, P. C. P.; ALMEIDA, J. C.; MELO, R. P. B.; SANTOS, A. S.; LIMA, D. C. V.; PINHEIRO JÚNIOR, J. W.; MOTA, R. A. Padronização de multiplex PCR para detecção de dermatófitos em pelos e crostas de cães e gatos. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 38, n. 9, p. 1824-1828, setembro 2018 Título em inglês: Standardization of a PCR multiplex for the detection of dermatophytes in dogs and cats fur and crusts.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 3. | | LIMA, D. C. V.; SIQUEIRA, D. B.; SILVA JUNIOR, V. A.; NERY, L. T. B.; ALBUQUERQUE, L. C. R. de; SOUZA, D. S.; MELO, C. C. S.; OLIVEIRA, E. C. S. Ectopic testis in coati (Nasua nasua Linnaeus, 1766). Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 36, n. 10, p. 999-1004, out. 2016.| Biblioteca(s): Embrapa Unidades Centrais. |
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