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 | Acesso ao texto completo restrito à biblioteca da Embrapa Recursos Genéticos e Biotecnologia. Para informações adicionais entre em contato com cenargen.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia. |
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Data corrente: |
04/06/2024 |
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Data da última atualização: |
21/01/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PAULA, V. G. de; SOUSA, R. S. de; SILVA, R. C. M. R. da; ALVES, E. G.; CAETANO, A. R.; IANELLA, P.; CAMPOS, T. A. de. |
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Afiliação: |
VICTOR GOMES DE PAULA, UNIVERSIDADE DE BRASÍLIA; RAYANE SARAFIM DE SOUSA, UNIVERSIDADE DE BRASÍLIA; RAFAELLA CHRISTINA MOREIRA ROCHA DA SILVA, UNIVERSIDADE DE BRASÍLIA; EVERTON GIOVANI ALVES, LABORATÓRIO CENTRAL DE SAÚDE DO DISTRITO FEDERAL; ALEXANDRE RODRIGUES CAETANO, CENARGEN; PATRICIA IANELLA, CENARGEN; TATIANA AMABILE DE CAMPOS, UNIVERSIDADE DE BRASÍLIA. |
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Título: |
Fim3–24/ptxP-3 genotype is associated to whooping cough outbreak in Brazilian Midwest: The selection of Bordetella pertussis strains driven by vaccine immunization. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Infection, Genetics and Evolution, v. 121, 105599, 2024. |
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DOI: |
https://doi.org/10.1016/j.meegid.2024.105599 |
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Idioma: |
Inglês |
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Conteúdo: |
Whopping cough (or Pertussis) is an acute infectious respiratory disease caused by Bordetella pertussis bacteria. The disease is highly transmissible and can be fatal in children under two years old. Since the introduction of vaccine immunization in 1940, Pertussis incidence decreased worldwide. In Brazil, the immunization was introduced in 1977 using the whole cell (wP) vaccine. Despite the high vaccination coverage, an unexpected increase in the number of observed Pertussis cases was observed in 2012. In this year, 2257 cases were reported exceeding the average incidence rate of <1000 cases per year until 2010. This outbreak reached a peak level in 2014 and ended in 2018 according to the Brazilian National Surveillance System (SINAN). To understand the relationship between the outbreak and the vaccination, bacterial isolates (n = 136) from the Brazilian Midwest region obtained during the outbreak were submitted to genotyping of two vaccine loci: ptxP and fim3. Most of isolates (102) were obtained from nursing children (29 days to 2 years old). Genotyping of 94 isolates revealed that fim3–24/ptxP-3 was the most prevalent genotype (68%) associated with the outbreak peak. Two additional genotypes were also observed: fim3–1/ptxP-3 (15%) and fim3–3/ptxP-3 (17%). Conversely, the fim3–1/ptxP-2 genotype, which is harbored by the strain used in the wP vaccine (Bp137), was not observed. These results showed that B. pertussis circulating strains in the outbreak analyzed were different from the strain used for Pertussis immunization in Brazil. These observations provide insights that could be used to target vaccination programs to prevent future whooping cough outbreaks in Brazil. MenosWhopping cough (or Pertussis) is an acute infectious respiratory disease caused by Bordetella pertussis bacteria. The disease is highly transmissible and can be fatal in children under two years old. Since the introduction of vaccine immunization in 1940, Pertussis incidence decreased worldwide. In Brazil, the immunization was introduced in 1977 using the whole cell (wP) vaccine. Despite the high vaccination coverage, an unexpected increase in the number of observed Pertussis cases was observed in 2012. In this year, 2257 cases were reported exceeding the average incidence rate of <1000 cases per year until 2010. This outbreak reached a peak level in 2014 and ended in 2018 according to the Brazilian National Surveillance System (SINAN). To understand the relationship between the outbreak and the vaccination, bacterial isolates (n = 136) from the Brazilian Midwest region obtained during the outbreak were submitted to genotyping of two vaccine loci: ptxP and fim3. Most of isolates (102) were obtained from nursing children (29 days to 2 years old). Genotyping of 94 isolates revealed that fim3–24/ptxP-3 was the most prevalent genotype (68%) associated with the outbreak peak. Two additional genotypes were also observed: fim3–1/ptxP-3 (15%) and fim3–3/ptxP-3 (17%). Conversely, the fim3–1/ptxP-2 genotype, which is harbored by the strain used in the wP vaccine (Bp137), was not observed. These results showed that B. pertussis circulating strains in the outbreak analyzed were differen... Mostrar Tudo |
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Palavras-Chave: |
Antigen selection; Fim3; Outbreak; Pertussis; PtxP; Whopping cough. |
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Thesaurus Nal: |
Bordetella pertussis; Vaccines. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02657naa a2200301 a 4500
001 2164651
005 2025-01-21
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024 7 $ahttps://doi.org/10.1016/j.meegid.2024.105599$2DOI
100 1 $aPAULA, V. G. de
245 $aFim3–24/ptxP-3 genotype is associated to whooping cough outbreak in Brazilian Midwest$bThe selection of Bordetella pertussis strains driven by vaccine immunization.$h[electronic resource]
260 $c2024
520 $aWhopping cough (or Pertussis) is an acute infectious respiratory disease caused by Bordetella pertussis bacteria. The disease is highly transmissible and can be fatal in children under two years old. Since the introduction of vaccine immunization in 1940, Pertussis incidence decreased worldwide. In Brazil, the immunization was introduced in 1977 using the whole cell (wP) vaccine. Despite the high vaccination coverage, an unexpected increase in the number of observed Pertussis cases was observed in 2012. In this year, 2257 cases were reported exceeding the average incidence rate of <1000 cases per year until 2010. This outbreak reached a peak level in 2014 and ended in 2018 according to the Brazilian National Surveillance System (SINAN). To understand the relationship between the outbreak and the vaccination, bacterial isolates (n = 136) from the Brazilian Midwest region obtained during the outbreak were submitted to genotyping of two vaccine loci: ptxP and fim3. Most of isolates (102) were obtained from nursing children (29 days to 2 years old). Genotyping of 94 isolates revealed that fim3–24/ptxP-3 was the most prevalent genotype (68%) associated with the outbreak peak. Two additional genotypes were also observed: fim3–1/ptxP-3 (15%) and fim3–3/ptxP-3 (17%). Conversely, the fim3–1/ptxP-2 genotype, which is harbored by the strain used in the wP vaccine (Bp137), was not observed. These results showed that B. pertussis circulating strains in the outbreak analyzed were different from the strain used for Pertussis immunization in Brazil. These observations provide insights that could be used to target vaccination programs to prevent future whooping cough outbreaks in Brazil.
650 $aBordetella pertussis
650 $aVaccines
653 $aAntigen selection
653 $aFim3
653 $aOutbreak
653 $aPertussis
653 $aPtxP
653 $aWhopping cough
700 1 $aSOUSA, R. S. de
700 1 $aSILVA, R. C. M. R. da
700 1 $aALVES, E. G.
700 1 $aCAETANO, A. R.
700 1 $aIANELLA, P.
700 1 $aCAMPOS, T. A. de
773 $tInfection, Genetics and Evolution$gv. 121, 105599, 2024.
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