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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com rosangela.lacerda@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
08/12/2016 |
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Data da última atualização: |
30/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BARROS, P. A. de; GENEROSO, S. V.; ANDRADE, M. E. R.; GAMA, M. A. S. da; LOPES, F. C. F.; SOUZA, É. L. de S. e; MARTINS, F. D.; MIRANDA, S. E. M.; FERNANDES, S. O. A.; CARDOSO, V. N. |
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Afiliação: |
Patricia Aparecida Vieira de Barros, UFMG; Simone de Vasconcelos Generoso, UFMG; Maria Emilia Rabelo Andrade, UFMG; MARCO ANTONIO SUNDFELD DA GAMA, CNPGL; FERNANDO CESAR FERRAZ LOPES, CNPGL; Ericka Lorenna de Sales e Souza, UFMG; Flaviano dos Santos Martins, UFMG; Sued Eustaquio Mendes Miranda, UFMG; Simone Odilia Antunes Fernandes, UFMG; Valbert Nascimento Cardoso, UFMG. |
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Título: |
Effect of conjugated linoleic acid-enriched butter after 24 hours of intestinal mucositis induction. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Nutrition and Cancer, v. 69, n. 1, p. 168-175, 2017. |
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Idioma: |
Inglês |
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Notas: |
Publicado online em 28 set. 2016. |
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Conteúdo: |
Mucositis is the most common side effect due to chemotherapy or radiotherapy. It refers to the inflammation of intestinal mucous membranes, and it is associated with complications such as diarrhea, weight loss, and increased intestinal permeability (IP). This study was designed to evaluate the effect of diet containing conjugated linoleic acid (CLA)-enriched butter on intestinal damage and inflammatory response after 24 h of 5-fluorouracil (5-FU)-induced mucositis. Mice were divided into four groups: CTL; CLA; 5-FU, and CLA 5-FU, and they were fed for 31 days. On the 30th experimental day, mucositis was induced by unique injection of 300 mg/kg of 5-FU. After 24 h (31st experimental day), IP was evaluated; ileum and fecal material were collected to determine cytokine level and myeloperoxidase (MPO) activity and secretory immunoglobulin A (sIgA). The 5-FU group showed an increase in IP and MPO activity (CTL vs. 5-FU: P < 0.05). Additionally, increased levels of IP and MPO were observed in CLA 5-FU group compared to those in the test groups (P < 0.05). Animals in the CLA 5-FU group showed reduced concentrations of sIgA (CTL vs. CLA 5-FU: P < 0.05). CLA-enriched butter exacerbating the 5-FU-induced intestinal damage. Safety concerns regarding the use of CLA require further investigation. |
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Palavras-Chave: |
CLA-enriched butter; Immunonutrients; Intestinal damage; Mucositis. |
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Thesaurus Nal: |
Fatty acids. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02220naa a2200301 a 4500
001 2058266
005 2023-01-30
008 2016 bl uuuu u00u1 u #d
100 1 $aBARROS, P. A. de
245 $aEffect of conjugated linoleic acid-enriched butter after 24 hours of intestinal mucositis induction.$h[electronic resource]
260 $c2016
500 $aPublicado online em 28 set. 2016.
520 $aMucositis is the most common side effect due to chemotherapy or radiotherapy. It refers to the inflammation of intestinal mucous membranes, and it is associated with complications such as diarrhea, weight loss, and increased intestinal permeability (IP). This study was designed to evaluate the effect of diet containing conjugated linoleic acid (CLA)-enriched butter on intestinal damage and inflammatory response after 24 h of 5-fluorouracil (5-FU)-induced mucositis. Mice were divided into four groups: CTL; CLA; 5-FU, and CLA 5-FU, and they were fed for 31 days. On the 30th experimental day, mucositis was induced by unique injection of 300 mg/kg of 5-FU. After 24 h (31st experimental day), IP was evaluated; ileum and fecal material were collected to determine cytokine level and myeloperoxidase (MPO) activity and secretory immunoglobulin A (sIgA). The 5-FU group showed an increase in IP and MPO activity (CTL vs. 5-FU: P < 0.05). Additionally, increased levels of IP and MPO were observed in CLA 5-FU group compared to those in the test groups (P < 0.05). Animals in the CLA 5-FU group showed reduced concentrations of sIgA (CTL vs. CLA 5-FU: P < 0.05). CLA-enriched butter exacerbating the 5-FU-induced intestinal damage. Safety concerns regarding the use of CLA require further investigation.
650 $aFatty acids
653 $aCLA-enriched butter
653 $aImmunonutrients
653 $aIntestinal damage
653 $aMucositis
700 1 $aGENEROSO, S. V.
700 1 $aANDRADE, M. E. R.
700 1 $aGAMA, M. A. S. da
700 1 $aLOPES, F. C. F.
700 1 $aSOUZA, É. L. de S. e
700 1 $aMARTINS, F. D.
700 1 $aMIRANDA, S. E. M.
700 1 $aFERNANDES, S. O. A.
700 1 $aCARDOSO, V. N.
773 $tNutrition and Cancer$gv. 69, n. 1, p. 168-175, 2017.
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Embrapa Gado de Leite (CNPGL) |
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| Biblioteca(s): Embrapa Arroz e Feijão. |
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