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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria Tropical. Para informações adicionais entre em contato com cnpat.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios. |
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Data corrente: |
02/01/2023 |
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Data da última atualização: |
29/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LIMA, L. F. DE; ANDRADE-PINHEIRO, J. C.; FREITAS, M. A.; SILVA, A. I. DA; FONSECA, V. J. A.; SILVA, T. G. DA; SILVA, J. C. P. DA; LIMA, R. H. DE; SALES, D. L.; NEVES, R. P.; BRITO, E. S. de; RIBEIRO, P. R. V.; CANUTO, K. M.; COUTINHO, H. D. M.; SIYADATPANAH, A.; KIM, B.; MORAIS-BRAGA, M. F. B. |
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Afiliação: |
LUCIENE FERREIRA DE LIMA, University Regional of Cariri; JACQUELINE COSMO ANDRADE-PINHEIRO, University Regional of Cariri; MARIA AUDILENE FREITAS, University Federal of Pernambuco; ADRIELY IDALINA DA SILVA, University Federal of Pernambuco; VICTOR JUNO ALENCAR FONSECA, University Regional of Cariri; TAÍS GUSMÃO DA SILVA, University Regional of Cariri; JOSEFA CAROLAINE PEREIRA DA SILVA, University Regional of Cariri; ROSILAINE HONORATO DE LIMA, University Regional of Cariri; DÉBORA LIMA SALES, University Regional of Cariri; REJANE PEREIRA NEVES, University Federal of Pernambuco; EDY SOUSA DE BRITO, CNAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; KIRLEY MARQUES CANUTO, CNPAT; HENRIQUE DOUGLAS MELO COUTINHO, University Regional of Cariri; ABOLGHASEM SIYADATPANAH, Birjand University of Medical Sciences; BONGLEE KIM, Kyung Hee University; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, University Regional of Cariri. |
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Título: |
Anti-Candida properties of Gossypium hirsutum L.: enhancement of fungal growth, biofilm production and antifungal resistance. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Pharmaceutics, v. 14, n. 698, 2022. |
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Páginas: |
18 p. |
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DOI: |
https://doi.org/10.3390/pharmaceutics140406982022 |
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Idioma: |
Inglês |
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Conteúdo: |
(1) Background: Candida is a genus of yeasts with notable pathogenicity and significant ability to develop antimicrobial resistance. Gossypium hirsutum L., a medicinal plant that is traditionally used due to its antimicrobial properties, has demonstrated significant antifungal activity. Therefore, this study investigated the chemical composition and anti-Candida effects of aqueous (AELG) and hydroethanolic (HELG) extracts obtained from the leaves of this plant. (2) Methods: The extracts were chemically characterized by UPLC-QTOF-MS/MS, and their anti-Candida activities were investigated by analyzing cell viability, biofilm production, morphological transition, and enhancement of antifungal resistance. (3) Results: The UPLC-QTOF-MS/MS analysis revealed the presence of twenty-one compounds in both AELG and HELG, highlighting the predominance of flavonoids. The combination of the extracts with fluconazole significantly reduced its IC50 values against Candida albicans INCQS 40006, Candida tropicalis INCQS 40042, and C. tropicalis URM 4262 strains, indicating enhanced antifungal activity. About biofilm production, significant inhibition was observed only for the AELG-treated C. tropicalis URM 4262 strain in comparison with the untreated control. Accordingly, this extract showed more significant inhibitory effects on the morphological transition of the INCQS 40006 and URM 4387 strains of C. albicans (4) Conclusions: Gossypium hirsutum L. presents promising antifungal effects, that may be potentially linked to the combined activity of chemical constituents identified in its extracts. Menos(1) Background: Candida is a genus of yeasts with notable pathogenicity and significant ability to develop antimicrobial resistance. Gossypium hirsutum L., a medicinal plant that is traditionally used due to its antimicrobial properties, has demonstrated significant antifungal activity. Therefore, this study investigated the chemical composition and anti-Candida effects of aqueous (AELG) and hydroethanolic (HELG) extracts obtained from the leaves of this plant. (2) Methods: The extracts were chemically characterized by UPLC-QTOF-MS/MS, and their anti-Candida activities were investigated by analyzing cell viability, biofilm production, morphological transition, and enhancement of antifungal resistance. (3) Results: The UPLC-QTOF-MS/MS analysis revealed the presence of twenty-one compounds in both AELG and HELG, highlighting the predominance of flavonoids. The combination of the extracts with fluconazole significantly reduced its IC50 values against Candida albicans INCQS 40006, Candida tropicalis INCQS 40042, and C. tropicalis URM 4262 strains, indicating enhanced antifungal activity. About biofilm production, significant inhibition was observed only for the AELG-treated C. tropicalis URM 4262 strain in comparison with the untreated control. Accordingly, this extract showed more significant inhibitory effects on the morphological transition of the INCQS 40006 and URM 4387 strains of C. albicans (4) Conclusions: Gossypium hirsutum L. presents promising antifungal effects, that... Mostrar Tudo |
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Palavras-Chave: |
Antimicrobial resistance; Biofilm eradication; Erradicação do biofilme; Resistência antimicrobiana; UPLC-QTOF-MS/MS. |
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Thesagro: |
Gossypium Hirsutum; Malvaceae. |
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Categoria do assunto: |
--
W Química e Física |
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Marc: |
LEADER 02880naa a2200421 a 4500
001 2153889
005 2024-02-29
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3390/pharmaceutics140406982022$2DOI
100 1 $aLIMA, L. F. DE
245 $aAnti-Candida properties of Gossypium hirsutum L.$benhancement of fungal growth, biofilm production and antifungal resistance.$h[electronic resource]
260 $c2022
300 $a18 p.
520 $a(1) Background: Candida is a genus of yeasts with notable pathogenicity and significant ability to develop antimicrobial resistance. Gossypium hirsutum L., a medicinal plant that is traditionally used due to its antimicrobial properties, has demonstrated significant antifungal activity. Therefore, this study investigated the chemical composition and anti-Candida effects of aqueous (AELG) and hydroethanolic (HELG) extracts obtained from the leaves of this plant. (2) Methods: The extracts were chemically characterized by UPLC-QTOF-MS/MS, and their anti-Candida activities were investigated by analyzing cell viability, biofilm production, morphological transition, and enhancement of antifungal resistance. (3) Results: The UPLC-QTOF-MS/MS analysis revealed the presence of twenty-one compounds in both AELG and HELG, highlighting the predominance of flavonoids. The combination of the extracts with fluconazole significantly reduced its IC50 values against Candida albicans INCQS 40006, Candida tropicalis INCQS 40042, and C. tropicalis URM 4262 strains, indicating enhanced antifungal activity. About biofilm production, significant inhibition was observed only for the AELG-treated C. tropicalis URM 4262 strain in comparison with the untreated control. Accordingly, this extract showed more significant inhibitory effects on the morphological transition of the INCQS 40006 and URM 4387 strains of C. albicans (4) Conclusions: Gossypium hirsutum L. presents promising antifungal effects, that may be potentially linked to the combined activity of chemical constituents identified in its extracts.
650 $aGossypium Hirsutum
650 $aMalvaceae
653 $aAntimicrobial resistance
653 $aBiofilm eradication
653 $aErradicação do biofilme
653 $aResistência antimicrobiana
653 $aUPLC-QTOF-MS/MS
700 1 $aANDRADE-PINHEIRO, J. C.
700 1 $aFREITAS, M. A.
700 1 $aSILVA, A. I. DA
700 1 $aFONSECA, V. J. A.
700 1 $aSILVA, T. G. DA
700 1 $aSILVA, J. C. P. DA
700 1 $aLIMA, R. H. DE
700 1 $aSALES, D. L.
700 1 $aNEVES, R. P.
700 1 $aBRITO, E. S. de
700 1 $aRIBEIRO, P. R. V.
700 1 $aCANUTO, K. M.
700 1 $aCOUTINHO, H. D. M.
700 1 $aSIYADATPANAH, A.
700 1 $aKIM, B.
700 1 $aMORAIS-BRAGA, M. F. B.
773 $tPharmaceutics$gv. 14, n. 698, 2022.
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Registro original: |
Embrapa Alimentos e Territórios (CNAT) |
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| Registros recuperados : 37 | |
| 8. |  | MUNIZ, C. R.; SILVA, G. F. da; SOUZA JUNIOR, M. T.; FREIRE, F. das C. O.; KEMA, G. H. J.; GUEDES, M. I. F. Agrobacterium tumefaciens-mediated transformation of Lasiodiplodia theobromae, the causal agent of gummosis in cashew nut plants. Genetics and Molecular Research, v. 13, n. 2, p. 2906-2913, 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agroindústria Tropical; Embrapa Amazônia Ocidental. |
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| 9. | | FURTADO, R. F.; DUTRA, R. A. F.; ALVES, C. R.; FÉLIX, W. P.; GUEDES, M. I. F.; SILVA, L. M. de A. Desenvolvimento de biossensor para detecção de traços de ricina em torta de mamona. In: WORKSHOP DE REDE DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO,3., 2007, Londrina. Anais... São Carlos: Embrapa Instrumentação Agropecuária, 2007. p. 13-15| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 10. | | PIMENTA, M. G. R.; FURTADO, R. F.; CARVALHO, J. B. de; SILVA, V. P. A. da; GUEDES, M. I. F.; DUTRA, R. F.; ALVES, C. R. Estudo da interação lectinas-carboidrato utilizando eletrodo convencional e ultramicroeletrodo. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE QUÍMICA, 32., 2009. Fortaleza. Resumos... Fortaleza: Sociedade Brasileira de Química, 2009. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 11. | | FREITAS, C. A. S.; VIEIRA, I. G. P.; SOUSA, P. H. M; MUNIZ, C. R.; GONZAGA, M. L. da C.; GUEDES, M. I. F. Carnauba wax p-methoxycinnamic diesters: Characterisation, antioxidant activity and simulated gastrointestinal digestion followed by in vitro bioaccessibility. Food Chemistry, v. 196, p. 1293-1300, 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 12. | | FURTADO, R. F.; SILVA, V. P. A. da; PIMENTA, M. G. R.; CARVALHO, J. B. de; ALVES, C. R.; GUEDES, M. I. F.; DUTRA, R. F. Imobilização de lectinas em superfície de ouro. In: SIMPÓSIO BRASILEIRO DE ELETROQUÍMICA E ELETROANALÍTICA, 17., 2009, Fortaleza. Anais... Fortaleza: Sociedade Brasileira de Química, 2009. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 13. | | ROCHA, M. E. B.; FREIRE, F. das C. O.; RONDINA, D.; GUEDES, M. I. F.; VIEIRA, I. G. P.; MENDES, F. N. P.; ALMEIDA, R. R. Produção de aflatoxinas por Aspergillus flavus em meios líquidos. In: CONGRESSO BRASILEIRO DE MICOLOGIA, 6., 2010, Brasília. Anais. Brasília: Sociedade Brasileira de Micologia, 2010. p. 465-466.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 14. | | FURTADO, R. F.; DUTRA, R. A. F.; ALVES, C. R.; GUEDES, M. I. F. LIMA, M. R.; SILVA, V. P. A. da. Produção de anticorpos policlonais anti-ricina. In: CONGRESSO BRASILEIRO DE MAMONA, 3., 2008, Salvador. Energia e ricinoquímica: anais. Salvador: Embrapa, 2008. 5 p. 1 CD ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 15. | | FURTADO, R. F.; PIMENTA, M. G. R.; SILVA, V. P. A. da; CARVALHO, J. B. de; GUEDES, M. I. F.; DUTRA, R. F.; ALVES, C. R. Perfil voltamétrico de galactose em superfície de ouro modificada quimicamente com lectinas. In: SIMPÓSIO BRASILEIRO DE ELETROQUÍMICA E ELETROANALÍTICA, 17., 2009, Fortaleza. Anais... Fortaleza: Sociedade Brasileira de Química, 2009. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 16. | | ALVES, C. R.; PIMENTA, M. G. R.; VIEIRA, R. H. S. F.; FURTADO, R. F.; GUEDES, M. I. F.; SILVA, R. C. B.; ASSIS, O. B. G. Practical use of immobilized iysozyme for the remediation process of Escherichia coli in aqueous solution. Electronic Journal of Biotechnology, Valparaíso, v. 10, n. 1, p. 161-165, 2007.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Instrumentação. |
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| 17. | | FURTADO, R. F.; DUARTE, A. M. S. F.; GUEDES, M. I. F.; ALVES, C. R.; DUTRA, R. A. F.; OLIVEIRA, M. R. Production of polyclonal antibodies against ricin. In: MEETING OF THE BRAZILIAN SOCIETY FOR IMMUNOLOGY, 33.; EXTRA SECTION OF CLINICAL IMMUNOLOGY, 2., 2008. Intervention in the immune system: abstract. Ribeirão Preto: Sociedade Brasileira de Imunologia, 2008.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 18. | | MUNIZ, C. R.; SILVA, G. F. da; FREIRE, F. das C. O.; GUEDES, M. I. F.; SOUZA JUNIOR, M. T.; KEMA, G.; JALINK, H. Relationships among Lasiodiplodia theobromae isolates associated with tropical fruit plants inferred from the analysis of ITS and EF1-a gene. In: EUROPEAN CONFERENCE ON FUNGAL GENETICS, 10., 2010, Leiden. Programme & Abstracts. Leiden, Holanda: Elsevier, 2010.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria Tropical; Embrapa Amazônia Ocidental. |
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| 19. | | MARQUES, C. G.; SILVA, B. B. DA; LIRA, S. M.; DIONISIO, A. P.; VAN TILBURG, M. F.; GUEDES, M. I. F.; RABELO, C. A. F. Red Pitaya (Hylocereus polyrhizus) as a Functional Food Nutritional Value, Phytochemical Content and Health-Promoting Effects. In: FREIRE, J. A. P.; MEDEIROS, S. R. A. ; AQUINO, J. DE S.; FEITOSA, CHISTIANE M.; MAHENDRA RAI (eds.). Bioprospection of Co-products and Agro-industrial Wastes A Sustainable Biotechnological Approach. Boca Raton: Boca Raton, 2023.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 20. | | MARQUES, c. m.; SILVA, B. B. DA; LIRA, S. M.; DIONISIO, A. P.; VAN TILBURG, M. F.; GUEDES, M. I. F.; RABELO, C. A. F. Red Pitaya (Hylocereus polyrhizus) as a Functional Food Nutritional Value, Phytochemical Content and Health-Promoting Effects. In: FREIRE, J. A. P.;MEDEIROS, S. R.A.; AQUINO, J. DE S.; FEITOSA, C. M.; RAI, M. (ed.). Bioprospection of Co-products and Agro-industrial Wastes A Sustainable Biotechnological Approach. Boca Raton: CRC, 2023.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| Registros recuperados : 37 | |
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