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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Oriental. Para informações adicionais entre em contato com cpatu.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
08/09/2017 |
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Data da última atualização: |
20/05/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
DUARTE JUNIOR, A. P.; TAVARES, E. J. M.; ALVES, T. V. G.; MOURA, M. R. de; COSTA, C. E. F. da; SILVA JÚNIOR, J. O. C.; COSTA, R. M. R. |
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Afiliação: |
Anivaldo Pereira Duarte Junior, UFPA; ERALDO JOSE MADUREIRA TAVARES, CPATU; Taís Vanessa Gabbay Alves, UFPA; Márcia Regina de Moura, UNESP; Carlos Emmerson Ferreira da Costa, UFPA; José Otávio Carréra Silva Júnior, UFPA; Roseane Maria Ribeiro Costa, UFPA. |
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Título: |
Chitosan nanoparticles as a modified diclofenac drug release system. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Journal of Nanoparticle Research, v. 19, n. 8, article 274, 2017. |
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DOI: |
10.1007/s11051-017-3968-6 |
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Idioma: |
Inglês |
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Conteúdo: |
This study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% ( w/ v) by template polymerization method using methacrylic acid in aqueous solution. Chitosan-poly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50?100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% ( w/ v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% ( w/ v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and obeyed Korsmeyer-Peppas model, which was characterized mainly by Fickian diffusion transport. MenosThis study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% ( w/ v) by template polymerization method using methacrylic acid in aqueous solution. Chitosan-poly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50?100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% ( w/ v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% ( w/ v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and o... Mostrar Tudo |
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Palavras-Chave: |
Biopolímero; Nanopartícula; Nanotecnologia; Quitosana. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 02347naa a2200253 a 4500
001 2075279
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008 2017 bl uuuu u00u1 u #d
024 7 $a10.1007/s11051-017-3968-6$2DOI
100 1 $aDUARTE JUNIOR, A. P.
245 $aChitosan nanoparticles as a modified diclofenac drug release system.$h[electronic resource]
260 $c2017
520 $aThis study evaluated a modified nanostructured release system employing diclofenac as a drug model. Biodegradable chitosan nanoparticles were prepared with chitosan concentrations between 0.5 and 0.8% ( w/ v) by template polymerization method using methacrylic acid in aqueous solution. Chitosan-poly(methacrylic acid) (CS-PMAA) nanoparticles showed uniform size around 50?100 nm, homogeneous morphology, and spherical shape. Raw material and chitosan nanoparticles were characterized by thermal analysis, Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM), confirming the interaction between chitosan and methacrylic acid during nanoparticles preparation. Diclofenac sorption on the chitosan nanoparticles surface was achieved by incubation in water/ethanol (1:1) drug solution in concentrations of 0.5 and 0.8 mg/mL. The diclofenac amount sorbed per gram of CS-PMAA nanoparticles, when in a 0.5 mg/mL sodium diclofenac solution, was as follows: 12.93, 15, 20.87, and 29.63 mg/g for CS-PMAA nanoparticles 0.5, 0.6, 0.7, and 0.8% ( w/ v), respectively. When a 0.8 mg/mL sodium diclofenac solution was used, higher sorption efficiencies were obtained: For CS-PMAA nanoparticles with chitosan concentrations of 0.5, 0.6, 0.7, and 0.8% ( w/ v), the sorption efficiencies were 33.39, 49.58, 55.23, and 67.2 mg/g, respectively. Diclofenac sorption kinetics followed a second-order kinetics. Drug release from nanoparticles occurred in a period of up to 48 h and obeyed Korsmeyer-Peppas model, which was characterized mainly by Fickian diffusion transport.
653 $aBiopolímero
653 $aNanopartícula
653 $aNanotecnologia
653 $aQuitosana
700 1 $aTAVARES, E. J. M.
700 1 $aALVES, T. V. G.
700 1 $aMOURA, M. R. de
700 1 $aCOSTA, C. E. F. da
700 1 $aSILVA JÚNIOR, J. O. C.
700 1 $aCOSTA, R. M. R.
773 $tJournal of Nanoparticle Research$gv. 19, n. 8, article 274, 2017.
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Embrapa Amazônia Oriental (CPATU) |
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| 14. |  | NHONGO, E. J. S.; FONTANA, D. C.; GUASSELLI, L. A.; ESQUERDO, J. C. D. M. Caracterização fenológica da cobertura vegetal com base em série temporal NDVI/MODIS na Reserva do Niassa. Revista Brasileira de Cartografia, Rio de Janeiro, v. 69, n. 6, p. 1175-1187, jun. 2017. Título equivalente em inglês: Phenological characterization of vegetation cover based on time series of NDVI / MODIS, in Niassa Reserve-Mozambique.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
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| 15. | | PINTO, D. G.; FONTANA, D. C.; DALMAGO, G. A.; VICARI, M. B.; FOCHESSATO, E. Análise da dinâmica temporal dos índices de vegetação NDVI, GNDVI e EVI obtidos em dossel de canola. In: CONGRESSO BRASILEIRO DE AGROMETEOROLOGIA, 19., 2015, Lavras, MG. Anais... Sensoriamento Remoto e Geoprocessamento, p. 1994-1998.| Tipo: Artigo em Anais de Congresso |
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| 18. | | FONTANA, D. C.; BERLATO, M. A.; LAUSCHNER, M. H.; MELLO, R. W. Modelo de estimativa de rendimento de soja no Estado do Rio Grande do Sul. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 36, n. 3, p. 399-403, mar. 2001 Título em inglês: Estimation model for soybean yield in the State of Rio Grande do Sul, Brazil.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 20. | | KLERING, E. V.; FONTANA, D. C.; BERLATO, M. A.; CARGNELUTTI FILHO, A. Modelagem agrometeorológica do rendimento de arroz irrigado no Rio Grande do Sul. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 43, n. 5, p. 549-558, maio 2008 Título em inglês: Agrometeorological modelling of irrigated rice yield in Rio Grande do Sul, Brazil.| Biblioteca(s): Embrapa Unidades Centrais. |
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| Registros recuperados : 42 | |
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