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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
23/01/2025 |
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Data da última atualização: |
23/01/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVA, B. P. M. DA; FANALLI, S. L.; GOMES, J. D.; ALMEIDA, V. V. DE; FUKUMASU, H.; MOREIRA, G. C. M.; VIGNATO, B. S.; AFONSO, J.; REECY, J. M.; KOLTES, J. E.; KOLTES, D.; BALIEIRO, J. C. DE. C.; REGITANO, L. C. de A.; ALENCAR, S. M. DE; MOURÃO, G. B.; COUTINHO, L. L.; LUCHIARI FILHO, A.; CESAR, A. S. M. |
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Afiliação: |
BRUNA PEREIRA MARTINS DA SILVA, UNIVERSIDADE DE SÃO PAULO; SIMARA LARISSA FANALLI, UNIVERSIDADE DE SÃO PAULO; JULIA DEZEN GOMES, UNIVERSIDADE DE SÃO PAULO; VIVIAN VEZZONI DE ALMEIDA, UNIVERSIDADE FEDERAL DE GOIÁS; HEIDGE FUKUMASU, UNIVERSIDADE DE SÃO PAULO; GABRIEL COSTA MONTEIRO MOREIRA, UNIVERSITY OF LIÈGE; BÁRBARA SILVA-VIGNATO, UNIVERSIDADE DE SÃO PAULO; JULIANA AFONSO; JAMES MARK REECY, IOWA STATE UNIVERSITY; JAMES EUGENE KOLTES, IOWA STATE UNIVERSITY; DAWN KOLTES, IOWA STATE UNIVERSITY; JÚLIO CESAR DE CARVALHO BALIEIRO, UNIVERSIDADE DE SÃO PAULO; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; SEVERINO MATIAS DE ALENCAR, UNIVERSIDADE DE SÃO PAULO; GERSON BARRETO MOURÃO, UNIVERSIDADE DE SÃO PAULO; LUIZ LEHMANN COUTINHO, UNIVERSIDADE DE SÃO PAULO; ALBINO LUCHIARI FILHO, UNIVERSIDADE DE SÃO PAULO; ALINE SILVA MELLO CESAR, UNIVERSIDADE DE SÃO PAULO. |
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Título: |
Different oil sources impacting brain lipid and transcriptome profiles of pigs. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Livestock Science, v. 284, June 2024, 105490. |
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DOI: |
https://doi.org/10.1016/j.livsci.2024.105490 |
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Idioma: |
Inglês |
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Conteúdo: |
Lipids are fundamental to the structure and function of the brain, and their fatty acids (FA) composition is rich in polyunsaturated fatty acids (PUFA), which have protective effects and modulate gene transcription. For nutrigenomics studies, pigs (Sus scrofa) have been widely used as a biomedical model. Thus, the aimed to investigate whether different dietary oil sources modify the pig brain's lipid and transcriptomic profile. A 98-day study was performed using fifty-four male pigs. Treatments consisted of corn-soybean meal diets containing 3 % of soybean oil (SOY), canola oil (CO), or fish oil (FO). Total mRNA was extracted for sequencing. As a result, feeding diets with different oil sources affected the percentage of some FA. Palmitic acid showed a greater concentration in diets containing SOY with 27.037 %. Oleic acid and eicosenoic acid, showed a greater concentration in diets containing SOY, with 30.968 % and 2.096 %, respectively; and, total PUFA showed a better concentration in diets containing SOY and FO, with 11.685 % and 12.150 %, respectively. After quality control, considering the total reads obtained for the three groups, 94.87% were mapped against the reference genome SScrofa11.1. A comparison of gene expression between the groups of pigs was carried out by using the DESeq2 statistical package (R/Bioconductor). From SOY vs CO comparison, five differentially expressed genes (DEG, FDR < 0.05) were identified, from SOY vs FO forty-four DEG were verified, and from CO vs FO thirty-nine DEG were found. The functional enrichment analysis resulted in pathway maps (P < 0.05) related to apoptosis and cell proliferation, obesity and type 2 diabetes, neurophysiological process, and inflammation. The networks were associated with signal transduction, calcium transport, and oxidative stress. Overall, the results showed that diets with different oil sources could affect some brain tissue parameters and may help guide future research on the availability of dietary FA in the brain. MenosLipids are fundamental to the structure and function of the brain, and their fatty acids (FA) composition is rich in polyunsaturated fatty acids (PUFA), which have protective effects and modulate gene transcription. For nutrigenomics studies, pigs (Sus scrofa) have been widely used as a biomedical model. Thus, the aimed to investigate whether different dietary oil sources modify the pig brain's lipid and transcriptomic profile. A 98-day study was performed using fifty-four male pigs. Treatments consisted of corn-soybean meal diets containing 3 % of soybean oil (SOY), canola oil (CO), or fish oil (FO). Total mRNA was extracted for sequencing. As a result, feeding diets with different oil sources affected the percentage of some FA. Palmitic acid showed a greater concentration in diets containing SOY with 27.037 %. Oleic acid and eicosenoic acid, showed a greater concentration in diets containing SOY, with 30.968 % and 2.096 %, respectively; and, total PUFA showed a better concentration in diets containing SOY and FO, with 11.685 % and 12.150 %, respectively. After quality control, considering the total reads obtained for the three groups, 94.87% were mapped against the reference genome SScrofa11.1. A comparison of gene expression between the groups of pigs was carried out by using the DESeq2 statistical package (R/Bioconductor). From SOY vs CO comparison, five differentially expressed genes (DEG, FDR < 0.05) were identified, from SOY vs FO forty-four DEG were verified, and fro... Mostrar Tudo |
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Palavras-Chave: |
Brain function; Differentially expressed genes; Lipid homeostasis; Pig model. |
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Thesaurus Nal: |
Fatty acids; Protective effect. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 03203naa a2200409 a 4500
001 2171933
005 2025-01-23
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.livsci.2024.105490$2DOI
100 1 $aSILVA, B. P. M. DA
245 $aDifferent oil sources impacting brain lipid and transcriptome profiles of pigs.$h[electronic resource]
260 $c2024
520 $aLipids are fundamental to the structure and function of the brain, and their fatty acids (FA) composition is rich in polyunsaturated fatty acids (PUFA), which have protective effects and modulate gene transcription. For nutrigenomics studies, pigs (Sus scrofa) have been widely used as a biomedical model. Thus, the aimed to investigate whether different dietary oil sources modify the pig brain's lipid and transcriptomic profile. A 98-day study was performed using fifty-four male pigs. Treatments consisted of corn-soybean meal diets containing 3 % of soybean oil (SOY), canola oil (CO), or fish oil (FO). Total mRNA was extracted for sequencing. As a result, feeding diets with different oil sources affected the percentage of some FA. Palmitic acid showed a greater concentration in diets containing SOY with 27.037 %. Oleic acid and eicosenoic acid, showed a greater concentration in diets containing SOY, with 30.968 % and 2.096 %, respectively; and, total PUFA showed a better concentration in diets containing SOY and FO, with 11.685 % and 12.150 %, respectively. After quality control, considering the total reads obtained for the three groups, 94.87% were mapped against the reference genome SScrofa11.1. A comparison of gene expression between the groups of pigs was carried out by using the DESeq2 statistical package (R/Bioconductor). From SOY vs CO comparison, five differentially expressed genes (DEG, FDR < 0.05) were identified, from SOY vs FO forty-four DEG were verified, and from CO vs FO thirty-nine DEG were found. The functional enrichment analysis resulted in pathway maps (P < 0.05) related to apoptosis and cell proliferation, obesity and type 2 diabetes, neurophysiological process, and inflammation. The networks were associated with signal transduction, calcium transport, and oxidative stress. Overall, the results showed that diets with different oil sources could affect some brain tissue parameters and may help guide future research on the availability of dietary FA in the brain.
650 $aFatty acids
650 $aProtective effect
653 $aBrain function
653 $aDifferentially expressed genes
653 $aLipid homeostasis
653 $aPig model
700 1 $aFANALLI, S. L.
700 1 $aGOMES, J. D.
700 1 $aALMEIDA, V. V. DE
700 1 $aFUKUMASU, H.
700 1 $aMOREIRA, G. C. M.
700 1 $aVIGNATO, B. S.
700 1 $aAFONSO, J.
700 1 $aREECY, J. M.
700 1 $aKOLTES, J. E.
700 1 $aKOLTES, D.
700 1 $aBALIEIRO, J. C. DE. C.
700 1 $aREGITANO, L. C. de A.
700 1 $aALENCAR, S. M. DE
700 1 $aMOURÃO, G. B.
700 1 $aCOUTINHO, L. L.
700 1 $aLUCHIARI FILHO, A.
700 1 $aCESAR, A. S. M.
773 $tLivestock Science$gv. 284, June 2024, 105490.
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Embrapa Pecuária Sudeste (CPPSE) |
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| 4. |  | BAYMA, M. M. A.; SA, C. P. de; FONSECA, F. L. da. Avaliação ambiental, social e econômica da recomendação das boas práticas na produção da castanha-do-brasil em florestas naturais do Acre. In: CONGRESSO DA SOCIEDADE BRASILEIRA DE ECONOMIA, ADMINISTRAÇÃO E SOCIOLOGIA RURAL, 51., 2013, Belém, PA. Novas fronteiras da agropecuária no Brasil e na Amazônia: desafios da sustentabilidade. Belém, PA: SOBER, 2013. 10 p.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Acre. |
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| 5. | | PORRO, R.; FONSECA, F. L. da; VALENTIM, J. F.; CARLINI, E. L. D. G. Acre. In: PORRO, R. (ed.). Atlas da Bioeconomia inclusiva na Amazônia informações e análises sobre realidades diferenciadas para subsídio a ações em sociobioeconomia. Brasília, DF: Embrapa, 2025. Cap. 2, p. 107-156.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Acre; Embrapa Amazônia Oriental; Embrapa Meio Ambiente. |
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| 12. | | FONSECA, F. L. da; GARCIA, M. F.; RINGENBERG, R.; FORESTI, J.; KOVALESKI, A. Aspectos biológicos de quatro linhagens de Trichogramma pretiosum (RILEY), em ovos de Bonagota cranaodes (MEYRICK). SIMPÓSIO DE CONTROLE BIOLÓGICO, 7., 2001, Poços de Caldas, MG. Anais... Poços de Caldas: Sociedade Entomológica do Brasil, 2001. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Uva e Vinho. |
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| 13. | | MARTINS, K.; FONSECA, F. L. da; BENTES, M. P. de M.; COSTA, P. da. Coleta e monitoramento da produção de oleorresina de copaíbas. In: WADT, L. H. de O.; SANTOS, L. M. H.; BENTES, M. P. de M.; OLIVEIRA, V. B. V. (ed.). Produtos florestais não madeireiros: guia metodológico da Rede Kamukaia. Brasília, DF: Embrapa, 2017. p. 119-123.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Acre; Embrapa Amazônia Oriental; Embrapa Roraima. |
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| 15. | | FONSECA, F. L. DA; GARCIA, M. S.; FORESTI, J.; RINGENBERG, R.; KOVALESKI, A. exigências térmicas de Trichogramma pretiosum (RILEY) em ovos de Bonagota cranaodes (MEYRICK) (LEPIDOPTERA:TORTRICIDAE) SIMPÓSIO DE CONTROLE BIOLÓGICO, 7., 2001, Poços de Caldas, MG. Anais... Poços de Caldas: Sociedade Entomológica do Brasil, 2001. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Uva e Vinho. |
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| 16. | | GARCIA, M. S.; FONSECA, F. L. da; FORESTI, J.; KOVALESKI, A.; RINGENBERG, R. Efeito da idade do hospedeiro no parasitismo de trichogramma pretiosum (RILEY), sobre ovos de Bonagota cranaodes (MEYRICK) (Lepidoptera:tortricidae). SIMPÓSIO DE CONTROLE BIOLÓGICO, 7., 2001, Poços de Caldas, MG. Anais... Poços de Caldas: Sociedade Entomológica do Brasil, 2001. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Uva e Vinho. |
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| 19. | | KOVALESKI, A.; GARCIA, M. S.; FONSECA, F. L. DA; RINGENBERG, R. Parasitismo de Trichogramma pretiosum (RILEY), sobre ovos de Bonagota cranaodes (MEYRICK), em condições de campo. SIMPÓSIO DE CONTROLE BIOLÓGICO, 7., 2001, Poços de Caldas, MG. Anais... Poços de Caldas: Sociedade Entomológica do Brasil, 2001. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Uva e Vinho. |
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| Registros recuperados : 40 | |
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