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 | Acesso ao texto completo restrito à biblioteca da Embrapa Florestas. Para informações adicionais entre em contato com cnpf.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Florestas. |
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Data corrente: |
02/07/2025 |
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Data da última atualização: |
07/07/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
TIMM, T. G.; TIMM, T. G.; PITZ, M. A. C.; HELM, C. V.; ALBERTON, M. D.; TAVARES, L. B. B.; MACHADO, I. D. |
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Afiliação: |
THAILISE GONÇALVES TIMM, UNIVERSIDADE REGIONAL DE BLUMENAU; THAYNÃ GONÇALVES TIMM, UNIVERSIDADE REGIONAL DE BLUMENAU; MAYRA ALICE CORRÊA PITZ, UNIVERSIDADE REGIONAL DE BLUMENAU; CRISTIANE VIEIRA HELM, CNPF; MICHELE DEBIASI ALBERTON, UNIVERSIDADE REGIONAL DE BLUMENAU; LORENA BENATHAR BALLOD TAVARES, UNIVERSIDADE REGIONAL DE BLUMENAU; ISABEL DAUFENBACK MACHADO, UNIVERSIDADE REGIONAL DE BLUMENAU. |
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Título: |
Immunomodulatory properties of a β-glucan-rich bioflour of Bactris gasipaes shells colonized by Lentinula edodes. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
Biocatalysis and Agricultural Biotechnology, v. 66, 103594, 2025. |
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DOI: |
https://doi.org/10.1016/j.bcab.2025.103594 |
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Idioma: |
Inglês |
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Conteúdo: |
Lentinula edodes β-glucans have shown potential in reducing lung injury caused by inflammation associated with severe acute respiratory syndrome (SARS). This study aimed to investigate the immunomodulatory properties related to lung inflammation, both in vitro and in vivo, of a high-β-glucan content bioflour derived from peach palm (Bactris gasipaes) shells colonized by Lentinula edodes (BPL). Neutrophils, L929, and A549 cells were treated (in vitro) with different doses (1, 10, 100 μg/mL) of BPL extracts (EBPL). The cells were subjected to cell viability assays, oxidative stress evaluation, and NO2 quantification. Male Swiss mice were divided into five groups (in vivo). Lung inflammation was induced via intranasal instillation of LPS (4 mg/kg), and the mice were treated orally with BPL. A control group received a vehicle or dexamethasone (0.5 mg/kg). Bronchoalveolar lavage (BAL) was collected to quantify total leukocytes, the mouse-to-lung weight ratio was calculated, and histological analysis was performed. Treatment with EBPL (in vitro) did not induce toxicity in cell lines and NO2 production decreased in neutrophils treated with the extracts; however, it did not reduce oxidative stress in A549 cells. A reduction in leukocytes was observed (in vivo) in BAL [11.43 × 105 (control), 9 × 105 (3 mg/kg), 3.33 × 105 (30 mg/kg), 1.43 × 105 (300 mg/kg) leukocytes/mL), histological infiltration, and a lower lung/mouse weight ratio [91.27 (control), 78.20 (3 mg/kg), 65.37 (30 mg/kg), 71.08 (300 mg/kg)]. This study highlights the nutraceutical potential of a β-glucan-rich food ingredient as an adjunct therapy for treating lung inflammation through dietary means, promoting human health and nutrition. MenosLentinula edodes β-glucans have shown potential in reducing lung injury caused by inflammation associated with severe acute respiratory syndrome (SARS). This study aimed to investigate the immunomodulatory properties related to lung inflammation, both in vitro and in vivo, of a high-β-glucan content bioflour derived from peach palm (Bactris gasipaes) shells colonized by Lentinula edodes (BPL). Neutrophils, L929, and A549 cells were treated (in vitro) with different doses (1, 10, 100 μg/mL) of BPL extracts (EBPL). The cells were subjected to cell viability assays, oxidative stress evaluation, and NO2 quantification. Male Swiss mice were divided into five groups (in vivo). Lung inflammation was induced via intranasal instillation of LPS (4 mg/kg), and the mice were treated orally with BPL. A control group received a vehicle or dexamethasone (0.5 mg/kg). Bronchoalveolar lavage (BAL) was collected to quantify total leukocytes, the mouse-to-lung weight ratio was calculated, and histological analysis was performed. Treatment with EBPL (in vitro) did not induce toxicity in cell lines and NO2 production decreased in neutrophils treated with the extracts; however, it did not reduce oxidative stress in A549 cells. A reduction in leukocytes was observed (in vivo) in BAL [11.43 × 105 (control), 9 × 105 (3 mg/kg), 3.33 × 105 (30 mg/kg), 1.43 × 105 (300 mg/kg) leukocytes/mL), histological infiltration, and a lower lung/mouse weight ratio [91.27 (control), 78.20 (3 mg/kg), 65.37 (30 mg/kg)... Mostrar Tudo |
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Palavras-Chave: |
Casca de pupunha; Immunomodulation Lung diseases; Imunomodulação; Mushroom; Nutraceutical; Nutracêuticos. |
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Thesagro: |
Bactris Gasipaes; Cogumelo; Doença Respiratória; Lentinula Edodes; Pulmão. |
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Categoria do assunto: |
Q Alimentos e Nutrição Humana |
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Marc: |
LEADER 02751naa a2200337 a 4500
001 2176968
005 2025-07-07
008 2025 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.bcab.2025.103594$2DOI
100 1 $aTIMM, T. G.
245 $aImmunomodulatory properties of a β-glucan-rich bioflour of Bactris gasipaes shells colonized by Lentinula edodes.$h[electronic resource]
260 $c2025
520 $aLentinula edodes β-glucans have shown potential in reducing lung injury caused by inflammation associated with severe acute respiratory syndrome (SARS). This study aimed to investigate the immunomodulatory properties related to lung inflammation, both in vitro and in vivo, of a high-β-glucan content bioflour derived from peach palm (Bactris gasipaes) shells colonized by Lentinula edodes (BPL). Neutrophils, L929, and A549 cells were treated (in vitro) with different doses (1, 10, 100 μg/mL) of BPL extracts (EBPL). The cells were subjected to cell viability assays, oxidative stress evaluation, and NO2 quantification. Male Swiss mice were divided into five groups (in vivo). Lung inflammation was induced via intranasal instillation of LPS (4 mg/kg), and the mice were treated orally with BPL. A control group received a vehicle or dexamethasone (0.5 mg/kg). Bronchoalveolar lavage (BAL) was collected to quantify total leukocytes, the mouse-to-lung weight ratio was calculated, and histological analysis was performed. Treatment with EBPL (in vitro) did not induce toxicity in cell lines and NO2 production decreased in neutrophils treated with the extracts; however, it did not reduce oxidative stress in A549 cells. A reduction in leukocytes was observed (in vivo) in BAL [11.43 × 105 (control), 9 × 105 (3 mg/kg), 3.33 × 105 (30 mg/kg), 1.43 × 105 (300 mg/kg) leukocytes/mL), histological infiltration, and a lower lung/mouse weight ratio [91.27 (control), 78.20 (3 mg/kg), 65.37 (30 mg/kg), 71.08 (300 mg/kg)]. This study highlights the nutraceutical potential of a β-glucan-rich food ingredient as an adjunct therapy for treating lung inflammation through dietary means, promoting human health and nutrition.
650 $aBactris Gasipaes
650 $aCogumelo
650 $aDoença Respiratória
650 $aLentinula Edodes
650 $aPulmão
653 $aCasca de pupunha
653 $aImmunomodulation Lung diseases
653 $aImunomodulação
653 $aMushroom
653 $aNutraceutical
653 $aNutracêuticos
700 1 $aTIMM, T. G.
700 1 $aPITZ, M. A. C.
700 1 $aHELM, C. V.
700 1 $aALBERTON, M. D.
700 1 $aTAVARES, L. B. B.
700 1 $aMACHADO, I. D.
773 $tBiocatalysis and Agricultural Biotechnology$gv. 66, 103594, 2025.
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Registro original: |
Embrapa Florestas (CNPF) |
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| Registros recuperados : 41 | |
| 9. |  | BARNI, P. E.; BARBOSA, R. I.; XAUD, H. A. M.; XAUD, M. R.; FEARNSIDE, P. M. Precipitação no extremo norte da Amazônia: distribuição espacial no estado de Roraima, Brasil. Sociedade & Natureza, v. 32, p. 439-456, 15 jul. 2020. Título em inglês: Precipitation in northern Amazonia: Spatial distribution in Roraima, Brazil.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Roraima. |
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| 10. | | MARQUES, J. D. de O.; LUIZÃO, F. J.; TEIXEIRA, W. G.; NOGUEIRA, E. M.; FEARNSIDE, P. M.; SARRAZIN, M. Soil carbon stocks under amazonian forest: distribution in the soil fractions and vulnerability to emission. Open Journal of Forestry, v. 7, n. 2, p. 121-142, Apr. 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 5 |
| Biblioteca(s): Embrapa Solos. |
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| 12. | | ZICCARDI, L. G.; GRAÇA, P. M. L. de A.; FIGUEIREDO, E. O.; YANAI, A. M.; FEARNSIDE, P. M. Community composition of tree and palm species following disturbance in a forest with bamboo in southwestern Amazonia, Brazil. Biotropica, v. 53, n. 5, p. 1328-1341, Sept. 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Acre. |
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| 13. | | FIGUEIREDO, E. O.; OLIVEIRA, M. V. N. d'; FEARNSIDE, P. M.; BRAZ, E. M.; PAPA, D. de A. Equations to estimate tree gaps in a precision forest management area the Amazon based on crown morphometry. Revista Árvore, Viçosa, v. 41, n. 3, e410313, 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Acre; Embrapa Florestas. |
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| 17. | | VASCONCELOS, S. S. de; FEARNSIDE, P. M.; GRAÇA, P. M. L. de A.; NOGUEIRA, E. M.; OLIVEIRA, L. C. de; FIGUEIREDO, E. O. Forest fires in southwestern Brazilian Amazonia: estimates of area and potential carbon emissions. Forest Ecology and Management, Amsterdam, v. 291, p. 199-208, Mar. 2013.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Acre. |
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| Registros recuperados : 41 | |
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