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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
09/06/2025 |
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Data da última atualização: |
09/06/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
OLIVEIRA, L. F. R.; TEODORO, K. B. R.; ANDRE, R. S.; COSTA, V. P. V.; CAVICCHIOLI, R.; MERCANTE, L. A.; SOUSA, C. P. de; CORREA, D. S. |
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Afiliação: |
FEDERAL UNIVERSITY OF SÃO CARLOS (UFSCAR); FEDERAL UNIVERSITY OF SÃO CARLOS (UFSCAR); FEDERAL UNIVERSITY OF SÃO CARLOS (UFSCAR); FEDERAL UNIVERSITY OF BAHIA (UFBA); FEDERAL UNIVERSITY OF SÃO CARLOS (UFSCAR); DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Combining Electrospun Nanofibers, Paenibacillus polymyxa Fermented Broth, and Silver Nanoparticles for Enhanced Antimicrobial Materials. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
BioNanoScience, v. 15, 356, 2025. |
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Páginas: |
13 p. |
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DOI: |
https://doi.org/10.1007/s12668-025-01950-2 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract The World Health Organization has identifed antimicrobial resistance as one of the top ten signifcant threats to global public health. For instance, it is predicted that conventional antibiotics will progressively lose their efcacy, accentuating the urgency to fnd innovative solutions to combat microorganisms. Eforts to develop novel antimicrobial agents are highly sought, as well as to explore the potential of natural products, such as plant extracts, and microbial secondary metabolites. In this direction, the Paenibacillus polymyxa RNC-D fermented broth (PFB), which is rich in antimicrobial peptides, was tested as component of nanostructured antimicrobial mat. For this, PFB was incorporated into polycaprolactone (PCL) nanofbers produced by electrospinning, which were further modifed with silver nanoparticles (AgNPs) to produce enhanced antimicrobial materials. The materials were physicochemically characterized using distinct techniques, while the microbiological studies were carried out using the agar disk difusion method, microbial penetration test and percentage of bacterial growth inhibition in suspension. The results showed that the incorporation of 25% of the PFB caused a signifcant improvement in the fber spinnability, resulting in nanofbers with less surface defects. Moreover, the wettability and hydrophilicity of the mats increased. Antimicrobial studies demonstrated the importance of the PFB to the formulation, which acted synergically, improving the distribution of AgNPs onto the fbers. While the fbrous mats demonstrated a protective efect against environmental microbes, when combined with AgNPs the PCL/PFB mats exhibited an inhibition halo of approximately 11.1±0.4 mm in the agar difusion test and showed capability of inhibiting the bacterial growth against E. coli. Therefore, our results demonstrate that combining electrospun nanofbers membrane, fermented broth and silver nanoparticles can be an alternative for developing enhanced antimicrobial materials with potential for biomedical applications. MenosAbstract The World Health Organization has identifed antimicrobial resistance as one of the top ten signifcant threats to global public health. For instance, it is predicted that conventional antibiotics will progressively lose their efcacy, accentuating the urgency to fnd innovative solutions to combat microorganisms. Eforts to develop novel antimicrobial agents are highly sought, as well as to explore the potential of natural products, such as plant extracts, and microbial secondary metabolites. In this direction, the Paenibacillus polymyxa RNC-D fermented broth (PFB), which is rich in antimicrobial peptides, was tested as component of nanostructured antimicrobial mat. For this, PFB was incorporated into polycaprolactone (PCL) nanofbers produced by electrospinning, which were further modifed with silver nanoparticles (AgNPs) to produce enhanced antimicrobial materials. The materials were physicochemically characterized using distinct techniques, while the microbiological studies were carried out using the agar disk difusion method, microbial penetration test and percentage of bacterial growth inhibition in suspension. The results showed that the incorporation of 25% of the PFB caused a signifcant improvement in the fber spinnability, resulting in nanofbers with less surface defects. Moreover, the wettability and hydrophilicity of the mats increased. Antimicrobial studies demonstrated the importance of the PFB to the formulation, which acted synergically, improving the dist... Mostrar Tudo |
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Palavras-Chave: |
Antimicrobial materials; Electrospinning; Electrospun nanofbers; Fermented broth; Secondary metabolite. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02963naa a2200289 a 4500
001 2176519
005 2025-06-09
008 2025 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s12668-025-01950-2$2DOI
100 1 $aOLIVEIRA, L. F. R.
245 $aCombining Electrospun Nanofibers, Paenibacillus polymyxa Fermented Broth, and Silver Nanoparticles for Enhanced Antimicrobial Materials.$h[electronic resource]
260 $c2025
300 $a13 p.
520 $aAbstract The World Health Organization has identifed antimicrobial resistance as one of the top ten signifcant threats to global public health. For instance, it is predicted that conventional antibiotics will progressively lose their efcacy, accentuating the urgency to fnd innovative solutions to combat microorganisms. Eforts to develop novel antimicrobial agents are highly sought, as well as to explore the potential of natural products, such as plant extracts, and microbial secondary metabolites. In this direction, the Paenibacillus polymyxa RNC-D fermented broth (PFB), which is rich in antimicrobial peptides, was tested as component of nanostructured antimicrobial mat. For this, PFB was incorporated into polycaprolactone (PCL) nanofbers produced by electrospinning, which were further modifed with silver nanoparticles (AgNPs) to produce enhanced antimicrobial materials. The materials were physicochemically characterized using distinct techniques, while the microbiological studies were carried out using the agar disk difusion method, microbial penetration test and percentage of bacterial growth inhibition in suspension. The results showed that the incorporation of 25% of the PFB caused a signifcant improvement in the fber spinnability, resulting in nanofbers with less surface defects. Moreover, the wettability and hydrophilicity of the mats increased. Antimicrobial studies demonstrated the importance of the PFB to the formulation, which acted synergically, improving the distribution of AgNPs onto the fbers. While the fbrous mats demonstrated a protective efect against environmental microbes, when combined with AgNPs the PCL/PFB mats exhibited an inhibition halo of approximately 11.1±0.4 mm in the agar difusion test and showed capability of inhibiting the bacterial growth against E. coli. Therefore, our results demonstrate that combining electrospun nanofbers membrane, fermented broth and silver nanoparticles can be an alternative for developing enhanced antimicrobial materials with potential for biomedical applications.
653 $aAntimicrobial materials
653 $aElectrospinning
653 $aElectrospun nanofbers
653 $aFermented broth
653 $aSecondary metabolite
700 1 $aTEODORO, K. B. R.
700 1 $aANDRE, R. S.
700 1 $aCOSTA, V. P. V.
700 1 $aCAVICCHIOLI, R.
700 1 $aMERCANTE, L. A.
700 1 $aSOUSA, C. P. de
700 1 $aCORREA, D. S.
773 $tBioNanoScience$gv. 15, 356, 2025.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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| Registros recuperados : 12 | |
| 2. |  | PETRINI, J.; DIAS, R. A. P.; PERTILE, S. F. N.; ELER, J. P.; FERRAZ, J. B. S.; MOURÃO, G. B. Degree of multicollinearity and variables involved in linear dependence in additive-dominant models. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 47, n. 12, p. 1743-1750, dez. 2012. Título em português: Grau de multicolinearidade e variáveis envolvidas na dependência linear em modelos aditivo-dominantes.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 4. | | PATRICIO, G. C. F.; EYHERABIDE, A. R.; DIAS, R. A.; TANNURI, U.; BRUNETTO, M. A.; CORTOPASSI, S. R. G. Early parenteral nutrition in enterectomized dogs. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 38, n. 3, p. 482-488, março 2018 Título em português: Nutrição parenteral precoce em cães submetidos à enterectomia.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 5. | | GUILLOUX, A. G. A.; PANACHÃO, L. I.; ALVES, A. J. S.; ZETUN, C. B.; CASSENOTE, A. J. F.; DIAS, R. A. Stray dogs in urban fragments: relation between population's perception of their presence and socio-demographic factors. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 38, n. 1, p. 89-93, janeiro 2018. Título em português: Cães errantes em fragmentos urbanos: relação entre o relato de visualização de cães errantes e fatores sociodemográficos da população local.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 6. | | GUIMARÃES, C. M.; STONE, L. F.; RANGEL, P. H. N.; FERREIRA, M. E.; ALENCAR, G. C. de O.; DIAS, R. A. A. Eficácia da avaliação radicular em condições controladas na fenotipagem para resistência à seca. In: CONGRESSO BRASILEIRO DE FISIOLOGIA VEGETAL, 11., 2007, Gramado. Fotossíntese: a essência da vida: resumos... Gramado: SBFV, 2007.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Arroz e Feijão; Embrapa Recursos Genéticos e Biotecnologia. |
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| 7. | | GUIMARÃES, C. M.; STONE, L. F.; LORIEUX, M.; OLIVEIRA, J. P. de; ALENCAR, G. C. de O.; DIAS, R. A. A. Infrared thermometry for drought phenotyping of inter and intra specific upland rice lines. Revista Brasileira de Engenharia Agrícola e Ambiental, v. 14, n. 2, p. 148-154, fev. 2010.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Arroz e Feijão. |
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| 8. | | SILVA, V. S.; MORÉS, N.; FERREIRA, F.; DIAS, R. A.; BALIAN, S.; DUTRA, V.; LEÃO, S. C.; PINHEIRO, S. R.; SAKAMOTO, S. M.; FERREIRA NETO, J. S. Identificação dos fatores de risco associados à ocorrência de micobacterioses no sul do Brasil: estudo caso - controle. Arquivos do Instituto Biológico, v.68, n.2, p.19-22, 2001.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 9. | | PADOVANI, C. R.; CAMOLESI JÚNIOR, L.; BONAFE, P.; VETTORAZZI, C. A.; DIAS, R. A. P.; DIAS, C. T. dos S.; SHIMABUKURO, Y. E.; GIRARD, P. Sistema de monitoramento e alerta de inundações e secas no Pantanal. SIMPÓSIO BRASILEIRO DE SENSORIAMENTO REMOTO, 15., Curitiba, 2011. Anais... São José dos Campos: INPE, 2011. p. 5140- 5147.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pantanal. |
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| 10. | | SAKAMOTO, S. M.; BALIAN, S. C.; LEAO, S. C.; SIRCILI, M. P.; MORES, N.; DUTRA, V.; SILVA, V. S.; CHIMARA, E.; FERREIRA, F.; PINHEIRO, S. R.; DIAS, R. A.; FERREIRA NETO, J. S. Epidemiologia e controle das micobacterioses suínas na Regiao Sul do Brasil: resultados preliminares. Arquivo do Instituto Biologico, v.65, p.92, 1998. Suplemento.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 11. | | LEAL FILHO, J. M.; BOTTENE, I. F. N.; MONTEIRO, L. A. R. C.; PELLEGRIN, A. O.; GONÇALVES, V. S. P.; FERREIRA, F.; DIAS, R. A.; AMAKU, M.; TELLES, E. O.; GRISI FILHO, J. H. H.; HEINEMANN, M. B.; FERREIRA NETO, J. S. Control of bovine brucellosis from 1998 to 2009 in the state of Mato Grosso do Sul, Brazil. Semina: Ciências Agrárias, Londrina, v. 37, n. 5, suplemento 2, p. 3467-3478, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Pantanal. |
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| 12. | | ANDRADE, B. O.; DRÖSE, W.; AGUIAR, C. A. de; AIRES, E. T.; ALVARES, D. J.; BARBIERI, R. L.; CARVALHO, C. J. B. de; BARTZ, M.; BECKER, F. G.; BENCKE, G. A.; BENEDUZI, A.; SILVA, J. B.; BLOCHTEIN, B.; BOLDRINI, I. I.; BOLL, P. K.; BORDIN, J.; SILVEIRA, R. M. B. da; MARTINS, M. B.; BOSENBECKER, C.; BRACCINI, J.; BRAUN, B.; BRITO, R.; BROWN, G. G.; BÜNEKER, H. M.; BUZATTO, C. R.; CAVALLERI, A.; CECHIN, S. Z.; COLOMBO, P.; CONSTANTINO, R.; COSTA, C. F. da; DALZOCHIO, M. S.; OLIVEIRA, M. G. de; DIAS, R. A.; SANTOS, L. A. dos; DUARTE, A. da F.; DUARTE, J. L. P.; DURIGON, J.; SILVA, M. E. da; FERREIRA, P. P. A.; FERREIRA, T.; FERRER, J.; FERRO, V. G.; FONTANA, C. S.; FREIRE, M. D.; FREITAS, T. R. O.; GALIANO, D.; GARCIA, M.; SANTOS, T. G. dos; GOMES, L. R. P.; GONZATTI, F.; GOTTSCHALK, M. S.; GRACIOLLI, G.; GRANADA, C. E.; GRINGS, M.; GUIMARÃES, P. S.; HEYDRICH, I.; IOP, S.; JARENKOW, J. A.; JUNGBLUTH, P.; KÄFFER, M. I.; KAMINSKI, L. A.; KENNE, D. C.; KIRST, F. D.; KROLOW, T. K.; KRÜGER, R. F.; KUBIAK, B. B.; LEAL-ZANCHET, A. M.; LOEBMANN, D.; LUCAS, D. B.; LUCAS, E. M.; LUZA, A. L.; MACHADO, I. F.; MADALOZZO, B.; MAESTRI, R.; MALABARBA, L. R.; MANEYRO, R.; MARINHO, M. A. T.; MARQUES, R.; MARTA, K. da S.; MARTINS, D. da S.; MARTINS, G. da S.; MARTINS, T. R.; MELLO, A. S. de; MELLO, R. L.; MENDONÇA JUNIOR, M. de S.; MORAIS, A. B. B. de; MOREIRA, F. F. F.; MOREIRA, L. F. B.; MOURA, L. de A.; NERVO, M. H.; OTT, R.; PALUDO, P.; PASSAGLIA, L. M. P.; PÉRICO, E.; PETZHOLD, E. S.; PIRES, M. M.; POPPE, J. L.; QUINTELA, F. M.; RAGUSE-QUADROS, M.; PEREIRA, M. J. R.; RENNER, S.; RIBEIRO, F. B.; RIBEIRO, J. R. I.; RODRIGUES, E. N. L.; RODRIGUES, P. E. S.; ROMANOWSKI, H. P.; RUSCHEL, T. P.; SACCOL, S. da S. A.; SAVARIS, M.; SILVEIRA, F. S.; SCHMITZ, H. J.; SIEGLOCH, A. E.; SIEWERT, R. R.; SILVA FILHO, P. J. S. da; SOARES, A. G.; SOMAVILLA, A.; SPEROTTO, P.; SPIES, M. R.; TIRELLI, F. P.; TOZETTI, A. M.; VERRASTRO, L.; ELY, C. V.; SILVA, Â. Z. da; ZANK, C.; ZEFA, E.; OVERBECK, G. E. 12,500+ and counting: biodiversity of the Brazilian Pampa. Frontiers of Biogeography, v. 15, n. 2, e59288, 2023. 1948-6596| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
| Biblioteca(s): Embrapa Clima Temperado; Embrapa Florestas. |
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| Registros recuperados : 12 | |
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