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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria Tropical. Para informações adicionais entre em contato com cnpat.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios. |
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Data corrente: |
10/12/2024 |
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Data da última atualização: |
03/01/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
FREIRE, G. DE P.; ALMEIDA FILHO, L. C. P.; RIBEIRO, P. R. V.; NUNES, P. I. G.; LIMA, R. P. DE; PORTELA, B. Y. M.; BRITO, E. S. de; ALVES, A. P. N. N.; VIANA, D. DE A.; URANO, C. A. DE F. F.; SANTOS, F. A. |
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Afiliação: |
GABRIELLE DE PAULA FREIRE, UNIVERSIDADE FEDERAL DO CEARÁ; LUIZ CARLOS PEREIRA ALMEIDA FILHO, UNIVERSIDADE FEDERAL DO CEARÁ; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; PAULO IURY GOMES NUNES, UNIVERSIDADE FEDERAL DO CEARÁ; RENAN PEREIRA DE LIMA, WEILL CORNELL MEDICINE; BENEDITO YAGO MACHADO PORTELA, UNIVERSIDADE FEDERAL DO CEARÁ; EDY SOUSA DE BRITO, CNAT; ANA PAULA NEGREIROS NUNES ALVES, UNIVERSIDADE FEDERAL DO CEARÁ; DANIEL DE ARAÚJO VIANA, CENTRO UNIVERSITÁRIO CHRISTUS; CARVALHO ANA DE FÁTIMA FONTENELE URANO, UNIVERSIDADE FEDERAL DO CEARÁ; FLAVIA ALMEIDA SANTOS, UNIVERSIDADE FEDERAL DO CEARÁ. |
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Título: |
Gastroprotective and ulcer healing efects of Lonchocarpus sericeus seed extract in rodents. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Revista Brasileira de Farmacognosia, v. 34, p. 1298–1312, 2024. |
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Páginas: |
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DOI: |
https://doi.org/10.1007/s43450-024-00577-w |
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Idioma: |
Inglês |
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Conteúdo: |
Lonchocarpus sericeus (Poir.) Kunth ex DC., Fabaceae, is traditionally used to treat stomach disorders and constipation. Previous studies examined its anti-inflammatory, antinociceptive, and hepatoprotective properties, but its potential as a gastroprotective agent remains unexplored. This study aimed to investigate the gastroprotective and gastric healing effects of the hexane extract of L. sericeus seeds and assess its acute toxicity. Gas chromatography revealed that the hexane extract contains eight fatty acids, with oleic acid, palmitic acid, and behenic acid being the most abundant. In mice, L. sericeus extract (0.8, 1.6, and 3.2 mg/kg, p.o.) significantly reduced gastric lesions induced by ethanol, while a seven-day treatment with the extract (25, 50, and 100 mg/kg, p.o.) significantly reduced lesion area and volume in acetic acid-induced gastric lesions in rats. The extract demonstrated an antioxidant effect in both models. The gastroprotective effect of the extract on ethanol-induced gastric lesions involved the inhibition of signaling pathways related to the stimulation of endogenous prostaglandins and nitric oxide and the activation of TRPV1 receptors but not potassium channels. The extract also protected against ethanol-induced depletion of gastric wall mucus and reduced gastric secretory volume and acidity, while increasing pH in pylorus-ligated mice. Gastric histological analysis revealed that the extract promotes reepithelialization and reduces hemorrhage and inflammation. In conclusion, L. sericeus extract exhibited gastroprotective effects against ethanol- and acetic acid-induced gastric ulcers, likely due to its antioxidant activity, preservation of gastric mucus, regulation of prostaglandins and nitric oxide release, TRPV1 receptors activation, and antisecretory activity, with no observed toxicity. MenosLonchocarpus sericeus (Poir.) Kunth ex DC., Fabaceae, is traditionally used to treat stomach disorders and constipation. Previous studies examined its anti-inflammatory, antinociceptive, and hepatoprotective properties, but its potential as a gastroprotective agent remains unexplored. This study aimed to investigate the gastroprotective and gastric healing effects of the hexane extract of L. sericeus seeds and assess its acute toxicity. Gas chromatography revealed that the hexane extract contains eight fatty acids, with oleic acid, palmitic acid, and behenic acid being the most abundant. In mice, L. sericeus extract (0.8, 1.6, and 3.2 mg/kg, p.o.) significantly reduced gastric lesions induced by ethanol, while a seven-day treatment with the extract (25, 50, and 100 mg/kg, p.o.) significantly reduced lesion area and volume in acetic acid-induced gastric lesions in rats. The extract demonstrated an antioxidant effect in both models. The gastroprotective effect of the extract on ethanol-induced gastric lesions involved the inhibition of signaling pathways related to the stimulation of endogenous prostaglandins and nitric oxide and the activation of TRPV1 receptors but not potassium channels. The extract also protected against ethanol-induced depletion of gastric wall mucus and reduced gastric secretory volume and acidity, while increasing pH in pylorus-ligated mice. Gastric histological analysis revealed that the extract promotes reepithelialization and reduces hemorrhage and i... Mostrar Tudo |
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Palavras-Chave: |
TRPV1 receptor activation. |
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Thesaurus Nal: |
Antioxidants; Fatty acids; Nitric oxide; Prostaglandins. |
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Categoria do assunto: |
W Química e Física |
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Marc: |
LEADER 02832naa a2200325 a 4500
001 2170288
005 2025-01-03
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s43450-024-00577-w$2DOI
100 1 $aFREIRE, G. DE P.
245 $aGastroprotective and ulcer healing efects of Lonchocarpus sericeus seed extract in rodents.$h[electronic resource]
260 $c2024
300 $a.
520 $aLonchocarpus sericeus (Poir.) Kunth ex DC., Fabaceae, is traditionally used to treat stomach disorders and constipation. Previous studies examined its anti-inflammatory, antinociceptive, and hepatoprotective properties, but its potential as a gastroprotective agent remains unexplored. This study aimed to investigate the gastroprotective and gastric healing effects of the hexane extract of L. sericeus seeds and assess its acute toxicity. Gas chromatography revealed that the hexane extract contains eight fatty acids, with oleic acid, palmitic acid, and behenic acid being the most abundant. In mice, L. sericeus extract (0.8, 1.6, and 3.2 mg/kg, p.o.) significantly reduced gastric lesions induced by ethanol, while a seven-day treatment with the extract (25, 50, and 100 mg/kg, p.o.) significantly reduced lesion area and volume in acetic acid-induced gastric lesions in rats. The extract demonstrated an antioxidant effect in both models. The gastroprotective effect of the extract on ethanol-induced gastric lesions involved the inhibition of signaling pathways related to the stimulation of endogenous prostaglandins and nitric oxide and the activation of TRPV1 receptors but not potassium channels. The extract also protected against ethanol-induced depletion of gastric wall mucus and reduced gastric secretory volume and acidity, while increasing pH in pylorus-ligated mice. Gastric histological analysis revealed that the extract promotes reepithelialization and reduces hemorrhage and inflammation. In conclusion, L. sericeus extract exhibited gastroprotective effects against ethanol- and acetic acid-induced gastric ulcers, likely due to its antioxidant activity, preservation of gastric mucus, regulation of prostaglandins and nitric oxide release, TRPV1 receptors activation, and antisecretory activity, with no observed toxicity.
650 $aAntioxidants
650 $aFatty acids
650 $aNitric oxide
650 $aProstaglandins
653 $aTRPV1 receptor activation
700 1 $aALMEIDA FILHO, L. C. P.
700 1 $aRIBEIRO, P. R. V.
700 1 $aNUNES, P. I. G.
700 1 $aLIMA, R. P. DE
700 1 $aPORTELA, B. Y. M.
700 1 $aBRITO, E. S. de
700 1 $aALVES, A. P. N. N.
700 1 $aVIANA, D. DE A.
700 1 $aURANO, C. A. DE F. F.
700 1 $aSANTOS, F. A.
773 $tRevista Brasileira de Farmacognosia$gv. 34, p. 1298–1312, 2024.
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Embrapa Agroindústria Tropical (CNPAT) |
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| 1. |  | MARQUES, T. R.; COSTA NETO, E. C. da; FOCHEZATTO, A.; MARQUES, C. S. S. Indústria frigorífica no Brasil: uma análise exploratória da concentração espacial. In: CONGRESSO DA SOCIEDADE BRASILEIRA DE ECONOMIA, ADMINISTRAÇÃO E SOCIOLOGIA RURAL, 55., 2017, Santa Maria, RS. Inovação, extensão e cooperação para o desenvolvimento. Brasília, DF: SOBER, 2017.| Tipo: Artigo em Anais de Congresso |
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