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Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia. |
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Data corrente: |
07/12/2015 |
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Data da última atualização: |
20/06/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PETRIZ, B. A.; ALMEIDA, J. A.; GOMES, C. P. C.; PEREIRA, R. W.; MURAD, A. M.; FRANCO, O. L. |
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Afiliação: |
Bernardo A. Petriz, UCB; Jeeser A. Almeida, UCB; Clarissa P. C. Gomes, UCB; Rinaldo W. Pereira, UCB; ANDRE MELRO MURAD, CENARGEN; Octavio l. Franco, UCB. |
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Título: |
NanoUPLC/MSE proteomic analysis reveals modulation on left ventricle proteome from hypertensive rats after exercise training. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Journal of Proteomics, v. 113, p. 351-365, 2015. |
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Idioma: |
Inglês |
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Conteúdo: |
NanoUPLC/MSE was used to verify the effects of 8 weeks of low (SHR-LIT = 4) and high (SHR-HIT = 4) intensity training over the left ventricle proteome of hypertensive rats (SHR-C = 4). Training enhanced the aerobic capacity and reduced the systolic blood pressure in all exercised rats.NanoUPLC/MSE identified 250 proteins, with 233 in common to all groups and 16 exclusive to SHR-C, 2 to SHR-LIT, and 2 to the SHR-HIT. Cardiac hypertrophy related proteins appeared only in SHR-C. The SHR-LIT enhanced the abundance of 30 proteins and diminished 6, while SHR-HIT enhanced the abundance of 39 proteins and reduced other 7. The levels of metabolic (? and ?-enolase, adenine phosphoribosultransferase, and cytochrome b-c1), myofibril (myosin light chain 4, tropomyosin ? and ?-chain), and transporter proteins (hemoglobin, serum albumin, and hemopexin)were increased by both intensities. Transcription regulator and histone variants were enhanced by SHR-LIT and SHR-HIT respectively. SHR-LIT reduced the concentration of myosin binding protein C, while desmin and membrane voltage dependent anion selective channel protein-3 were reduced only by SHR-HIT. In addition, polyubiquitin B and C, and transcription regulators decreased in both intensities. Exercise also increased the concentration of anti-oxidant proteins, peroxiredozin-6 and glutathione peroxidase-1. Biological significance Pathologic left ventricle hypertrophy if one of the major outcomes of hypertension being a strong predictor of heart failure. Among the various risk factors for cardiovascular disorders, arterial hypertension is responsible for the highest rates of mortality worldwide. In this way,this present study contribute to the understanding of the molecular mechanisms involved in the attenuation of hypertension and the regression of pathological cardiac hypertrophy induced by exercise training. MenosNanoUPLC/MSE was used to verify the effects of 8 weeks of low (SHR-LIT = 4) and high (SHR-HIT = 4) intensity training over the left ventricle proteome of hypertensive rats (SHR-C = 4). Training enhanced the aerobic capacity and reduced the systolic blood pressure in all exercised rats.NanoUPLC/MSE identified 250 proteins, with 233 in common to all groups and 16 exclusive to SHR-C, 2 to SHR-LIT, and 2 to the SHR-HIT. Cardiac hypertrophy related proteins appeared only in SHR-C. The SHR-LIT enhanced the abundance of 30 proteins and diminished 6, while SHR-HIT enhanced the abundance of 39 proteins and reduced other 7. The levels of metabolic (? and ?-enolase, adenine phosphoribosultransferase, and cytochrome b-c1), myofibril (myosin light chain 4, tropomyosin ? and ?-chain), and transporter proteins (hemoglobin, serum albumin, and hemopexin)were increased by both intensities. Transcription regulator and histone variants were enhanced by SHR-LIT and SHR-HIT respectively. SHR-LIT reduced the concentration of myosin binding protein C, while desmin and membrane voltage dependent anion selective channel protein-3 were reduced only by SHR-HIT. In addition, polyubiquitin B and C, and transcription regulators decreased in both intensities. Exercise also increased the concentration of anti-oxidant proteins, peroxiredozin-6 and glutathione peroxidase-1. Biological significance Pathologic left ventricle hypertrophy if one of the major outcomes of hypertension being a strong predictor of he... Mostrar Tudo |
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Palavras-Chave: |
Análise proteômica; Hipertensão. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02514naa a2200205 a 4500
001 2030868
005 2024-06-20
008 2015 bl uuuu u00u1 u #d
100 1 $aPETRIZ, B. A.
245 $aNanoUPLC/MSE proteomic analysis reveals modulation on left ventricle proteome from hypertensive rats after exercise training.$h[electronic resource]
260 $c2015
520 $aNanoUPLC/MSE was used to verify the effects of 8 weeks of low (SHR-LIT = 4) and high (SHR-HIT = 4) intensity training over the left ventricle proteome of hypertensive rats (SHR-C = 4). Training enhanced the aerobic capacity and reduced the systolic blood pressure in all exercised rats.NanoUPLC/MSE identified 250 proteins, with 233 in common to all groups and 16 exclusive to SHR-C, 2 to SHR-LIT, and 2 to the SHR-HIT. Cardiac hypertrophy related proteins appeared only in SHR-C. The SHR-LIT enhanced the abundance of 30 proteins and diminished 6, while SHR-HIT enhanced the abundance of 39 proteins and reduced other 7. The levels of metabolic (? and ?-enolase, adenine phosphoribosultransferase, and cytochrome b-c1), myofibril (myosin light chain 4, tropomyosin ? and ?-chain), and transporter proteins (hemoglobin, serum albumin, and hemopexin)were increased by both intensities. Transcription regulator and histone variants were enhanced by SHR-LIT and SHR-HIT respectively. SHR-LIT reduced the concentration of myosin binding protein C, while desmin and membrane voltage dependent anion selective channel protein-3 were reduced only by SHR-HIT. In addition, polyubiquitin B and C, and transcription regulators decreased in both intensities. Exercise also increased the concentration of anti-oxidant proteins, peroxiredozin-6 and glutathione peroxidase-1. Biological significance Pathologic left ventricle hypertrophy if one of the major outcomes of hypertension being a strong predictor of heart failure. Among the various risk factors for cardiovascular disorders, arterial hypertension is responsible for the highest rates of mortality worldwide. In this way,this present study contribute to the understanding of the molecular mechanisms involved in the attenuation of hypertension and the regression of pathological cardiac hypertrophy induced by exercise training.
653 $aAnálise proteômica
653 $aHipertensão
700 1 $aALMEIDA, J. A.
700 1 $aGOMES, C. P. C.
700 1 $aPEREIRA, R. W.
700 1 $aMURAD, A. M.
700 1 $aFRANCO, O. L.
773 $tJournal of Proteomics$gv. 113, p. 351-365, 2015.
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| 2. |  | CEDROLA, F.; MARTINELE, I.; PAIVA, P. C. A.; LOPES, F. C. F.; PEREIRA, J.; FERREIRA, L.; LEMES, M.; FERNANDES, E. Fatty acid profile in sheep fed diets based on potato bran pellets with urea. In: ANNUAL MEETING BRAZILIAN SOCIETY OF ANIMAL SCIENCE, 50., 2013, Campinas. Proceedings... Viçosa, MG: Sociedade Brasileira de Zootecnia, 2013.| Tipo: Resumo em Anais de Congresso |
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| 3. | | bovino; ROSSI, M.; CEDROLA, F.; MARTINELE, I.; MOURTHÉ, M. H. F.; LOPES, F. C. F.; D’AGOSTO, M. Grão de soja tostado na dieta de vacas em lactação e seus efeitos sobre os protozoários ruminais. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 48., 2011, Belém, PA. O desenvolvimento da produção animal e a responsabilidade frente a novos desafios: anais. Viçosa, MG: Sociedade Brasileira de Zootecnia, 2011.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 4. | | CEDROLA, F.; ROSSI, M.; LOPES, R. P. X.; RIBEIRO, M. T.; OLIVEIRA, J. S. e; D'AGOSTO, M. Glicerina bruta na dieta de vacas em lactação e seus efeitos sobre os protozoários ciliados ruminais. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 49., 2012, Brasília. A produção animal no mundo em transformação: anais. Brasília, DF: SBZ, 2012.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 5. | | SANTANA NETO, J. A.; MARTINELE, I.; CEDROLA, F.; SANTOS, G. R. de A.; MUNIZ, E. N.; SOUZA, E. Y. B.; CASTRO FILHO, E. S.; DAGOSTO, M. Apparent digestibility and rumen protozoal profile of sheep fed cassava wastewater. Revista Brasileira de Saúde e Produção Animal, Salvador, v. 18, n. 2, p. 327-336, abr./jun. 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
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