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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
05/07/2023 |
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Data da última atualização: |
27/11/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
TEODORO, K. B. R.; ALVARENGA, A. D.; OLIVEIRA, L. F. R.; CHAGAS, P. A. M.; LOPES. R. G.; ANDRE, R. S.; MERCANTE, L. A.; ALVES, F.; STRINGASCI, M. D.; BUZZA, H. H.; INADA, N. M.; CORREA, D. S. |
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Afiliação: |
KELCILENE BRUNA RICARDO TEODORO, UNIVERSIDADE FEDERAL DE SÃO CARLOS; AUGUSTO D. ALVARENGA; LUÍS FERNANDO ROCHA OLIVEIRA, UNIVERSIDADE FEDERAL DE SÃO CARLOS; PAULO AUGUSTO MARQUES CHAGAS, UNIVERSIDADE FEDERAL DE SÃO CARLOS (UFSCAR); RAPHAEL GUIMARÃES LOPES, UNIVERSIDADE FEDERAL DO TRIÂNGULO MINEIRO; RAFAELA DA SILVEIRA ANDRE, UNIVERSIDADE FEDERAL DE SÃO CARLOS; LUIZA AMIM MERCANTE, UNIVERSIDADE FEDERAL DA BAHIA (UFBA); FERNANDA ALVES; MIRIAN DENISE STRINGASCI, UNIVERSIDADE ESTADUAL DE CAMPINAS; HILDE HARB BUZZA, UNIVERSIDADE DE SÃO PAULO (USP); NATALIA MAYUMI INADA, UNIVERSIDADE DE SÃO PAULO (USP); DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Fast Fabrication of Multifunctional PCL/Curcumin Nanofibrous Membranes for Wound Dressings. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
ACS Applied Bio Materials, v. 6, 2023. |
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Páginas: |
2325–2337 |
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DOI: |
https://doi.org/10.1021/acsabm.3c00177 |
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Idioma: |
Inglês |
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Conteúdo: |
herapeutic intervention to skin wounds requires covering the affected area with wound dressings. Interdisciplinary efforts have focused on the development of smart bandages that can perform multiple functions. In this direction, here, we designed a low cost (U$0.012 per cm2 ) multifunctional therapeutic wound dressing fabricated by loading curcumin (CC) into poly(ϵ-caprolactone) (PCL) nanofibers using solution blow spinning (SBS). The freestanding PCL/CC bandages were characterized by distinct physicochemical approaches and were successful in performing varied functions, including controlled release of CC, colorimetric indication of the wound conditions, barrier against microorganisms, being biocompatible, and providing a photosensitive platform for antimicrobial photodynamic therapy (aPDT). The chemical nature of PCL and CC and the interactions between these components allowed CC to be released for 192 h (ca. 8 days), which could be correlated with the Korsmeyer−Peppas model, with a burst release suitable to treat the inflammatory phase. Due to the CC keto−enol tautomerism, an optical indication of the healing status could be obtained using PCL/CC, which occurred immediately, ranging between red/orange and yellow shades. The effect against pathogenic microorganisms evaluated by agar disc-diffusion, affected skin wound simulation (ex vivo), and microbial penetration tests demonstrated the ability to block and inhibit microbial permeation in different environments. The biocompatibilities of PCL and PCL/CC were verified by in vitro cytotoxicity study, which demonstrated that cell viabilities average above 94 and 96% for human dermal fibroblasts. In addition, the proposed bandage responded to aPDT applied to an in vivo assay, showing that, when irritated, PCL/CC was able to reduce the bacteria present on the real wound of mice. In summary, our findings demonstrate that using PCL and CC to produce nonwovens by the SBS technique offers potential for the rapid fabrication of biocompatible and multifunctional wound dressings, paving the way for large-scale production and utilization of such dressings in the treatment of skin wounds. Menosherapeutic intervention to skin wounds requires covering the affected area with wound dressings. Interdisciplinary efforts have focused on the development of smart bandages that can perform multiple functions. In this direction, here, we designed a low cost (U$0.012 per cm2 ) multifunctional therapeutic wound dressing fabricated by loading curcumin (CC) into poly(ϵ-caprolactone) (PCL) nanofibers using solution blow spinning (SBS). The freestanding PCL/CC bandages were characterized by distinct physicochemical approaches and were successful in performing varied functions, including controlled release of CC, colorimetric indication of the wound conditions, barrier against microorganisms, being biocompatible, and providing a photosensitive platform for antimicrobial photodynamic therapy (aPDT). The chemical nature of PCL and CC and the interactions between these components allowed CC to be released for 192 h (ca. 8 days), which could be correlated with the Korsmeyer−Peppas model, with a burst release suitable to treat the inflammatory phase. Due to the CC keto−enol tautomerism, an optical indication of the healing status could be obtained using PCL/CC, which occurred immediately, ranging between red/orange and yellow shades. The effect against pathogenic microorganisms evaluated by agar disc-diffusion, affected skin wound simulation (ex vivo), and microbial penetration tests demonstrated the ability to block and inhibit microbial permeation in different enviro... Mostrar Tudo |
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Palavras-Chave: |
Natural dye; Optical sensor; Photodynamic therapy; Solution blow spinning; Wound dressing. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03154naa a2200337 a 4500
001 2154815
005 2024-11-27
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1021/acsabm.3c00177$2DOI
100 1 $aTEODORO, K. B. R.
245 $aFast Fabrication of Multifunctional PCL/Curcumin Nanofibrous Membranes for Wound Dressings.$h[electronic resource]
260 $c2023
300 $a2325–2337
520 $aherapeutic intervention to skin wounds requires covering the affected area with wound dressings. Interdisciplinary efforts have focused on the development of smart bandages that can perform multiple functions. In this direction, here, we designed a low cost (U$0.012 per cm2 ) multifunctional therapeutic wound dressing fabricated by loading curcumin (CC) into poly(ϵ-caprolactone) (PCL) nanofibers using solution blow spinning (SBS). The freestanding PCL/CC bandages were characterized by distinct physicochemical approaches and were successful in performing varied functions, including controlled release of CC, colorimetric indication of the wound conditions, barrier against microorganisms, being biocompatible, and providing a photosensitive platform for antimicrobial photodynamic therapy (aPDT). The chemical nature of PCL and CC and the interactions between these components allowed CC to be released for 192 h (ca. 8 days), which could be correlated with the Korsmeyer−Peppas model, with a burst release suitable to treat the inflammatory phase. Due to the CC keto−enol tautomerism, an optical indication of the healing status could be obtained using PCL/CC, which occurred immediately, ranging between red/orange and yellow shades. The effect against pathogenic microorganisms evaluated by agar disc-diffusion, affected skin wound simulation (ex vivo), and microbial penetration tests demonstrated the ability to block and inhibit microbial permeation in different environments. The biocompatibilities of PCL and PCL/CC were verified by in vitro cytotoxicity study, which demonstrated that cell viabilities average above 94 and 96% for human dermal fibroblasts. In addition, the proposed bandage responded to aPDT applied to an in vivo assay, showing that, when irritated, PCL/CC was able to reduce the bacteria present on the real wound of mice. In summary, our findings demonstrate that using PCL and CC to produce nonwovens by the SBS technique offers potential for the rapid fabrication of biocompatible and multifunctional wound dressings, paving the way for large-scale production and utilization of such dressings in the treatment of skin wounds.
653 $aNatural dye
653 $aOptical sensor
653 $aPhotodynamic therapy
653 $aSolution blow spinning
653 $aWound dressing
700 1 $aALVARENGA, A. D.
700 1 $aOLIVEIRA, L. F. R.
700 1 $aCHAGAS, P. A. M.
700 1 $aLOPES. R. G.
700 1 $aANDRE, R. S.
700 1 $aMERCANTE, L. A.
700 1 $aALVES, F.
700 1 $aSTRINGASCI, M. D.
700 1 $aBUZZA, H. H.
700 1 $aINADA, N. M.
700 1 $aCORREA, D. S.
773 $tACS Applied Bio Materials$gv. 6, 2023.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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| Registros recuperados : 15 | |
| 3. |  | MAPELI, A. M.; FINGER, F. L.; OLIVEIRA, L. S. de; BARBOSA, J. G. Longevidade de inflorescências de Epidendrum ibaguense tratadas com aminoetoxivinilglicina. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 44, n. 3, p. 258-262, mar. 2009. Título em inglês: Extending vase life of cut Epidendrum ibaguense inflorescences with aminoethoxyvinylglycine.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 4. | | FERNANDES, A. A.; PRIETO MARTINEZ, H. E.; SILVA, D. J. H. da; BARBOSA, J. G. Produção de mudas de tomateiro por meio de estacas enraizadas em hidroponia. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 39, n. 4, p. 343-348, abr. 2004 Título em inglês: Tomato seedling production through rooted cuttings in hydroponic.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 5. | | FERNANDES, A. A.; MARTINEZ, H. E. P.; SILVA, D. J. H. da; BARBOSA, J. G.; PEDROSA, A. W. Cultivo sucessivo de plantas de tomate oriundas de sementes e propagação vegetativa em sistema hidropônico Pesquisa Agropecuária Brasileira, Brasília, DF, v. 42, n. 7, p. 1013-1019, jul. 2007 Título em inglês: Successively cultivated tomato plants originated from seeds and vegetative propagation in hydroponic system.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 6. | | CARNEIRO, T. F.; FINGER, F. L.; SANTOS, V. R. dos; NEVES, L. L. de M.; BARBOSA, J. G. Influência da sacarose e do corte da base da haste na longevidade de inflorescências de Zinnia elegans. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 37, n. 8, p. 1065-1070, ago. 2002 Título em inglês: Longevity of Zinnia elegans inflorescences affected by sucrose and recuts of the stem.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 8. | | MORANDI, M. A. B.; MAFFIA, L. A.; MIZUBUTI, E. S. G.; ALFENAS, A. C.; BARBOSA, J. G.; CRUZ, C. D. Relationships of microclimatic variables to colonization of rose debris by Botrytis cinerea and the biocontrol agent Clonostachys rosea. Biocontrol Science and Technology, Abingdon, v. 16, n. 6, p. 619-630, jun. 2006.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Meio Ambiente. |
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| 9. | | MORANDI, M. A. B.; MAFFIA, L. A.; MIZUBUTI, E. S. G.; ALFENAS, A. C.; BARBOSA, J. G. Suppression of Botrytis cinerea sporulation by Clonostachys rosea on rose debris: a valuable component in Botrytis blight management in commercial greenhouses. Biological Control, Orlando, v. 26, n. 3, p. 311-317, 2003.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Meio Ambiente. |
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| 10. | | BACKES, F. A. A. L.; BARBOSA, J. G.; CECON, P. R.; GROSSI, J. A. S.; BACKES, R. L.; FINGER, F. L. Cultivo hidropônico de lisianto para flor de corte em sistema de fluxo laminar de nutrientes Pesquisa Agropecuária Brasileira, Brasília, DF, v. 42, n. 11, p. 1561-1566, nov. 2007 Título em inglês: Hydroponic growth of lisianthus as cut flower under nutrient film technique.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 11. | | SOUZA, S. O.; FINGER, F. L.; LIMA, M. A. C. de; OLIVEIRA, A. H.; SANTOS, A. C. N. dos; COSTA, A. C. S.; BARBOSA, J. G. Influence of ethylene on senescence of Heliconia psittacorum x H. spathocircinata cv. Golden Torch. In: INTERNATIONAL SYMPOSIUM ON POSTHARVEST QUALITY OF ORNAMENTAL PLANTS, 9., 2008, Odense, Denmark. [Abstracts...]. Odense, Denmark: ISHS, 2008. p. 91.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Semiárido. |
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| 12. | | SOUZA, S. O. de; SOUSA, S. C. C. de; LIMA, M. A. C. de; OLIVEIRA, A. H.; BARBOSA, J. G.; FINGER, F. L. Longevity and quality of Heliconia psittacorum x H. spathocircinata 'Golden Torch' treated with 8-hydroxyquinoline citrate. In: INTERNATIONAL SYMPOSIUM ON POSTHARVEST QUALITY OF ORNAMENTAL PLANTS, 10., 2012, Porto de Galinhas. Book of abstract. Recife: UFRPE, 2012. p. 67.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria de Alimentos. |
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| 13. | | SOUZA, S. O. de; SOUSA, S. C. C. de; LIMA, M. A. C. de; OLIVEIRA, A. H.; BARBOSA, J. G.; FINGER, F. L. Longevity and quality of Heliconia psittacorum x H. spathocircinata 'Golden Torch' treated with 8-hydroxyquinoline citrate. Acta Horticulturae, Leuven, n. 1060, p. 187-192, jan. 2015. Edição do Proceedings of the X International Symposium on Postharvest Quality of Ornamental Plants, Porto de Galinhas, PE, 2012.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
| Biblioteca(s): Embrapa Semiárido. |
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| 14. | | SOUZA, S. O. de; SOUSA, S. C. C. de; LIMA, M. A. C. de; OLIVEIRA, A. H.; BARBOSA, J. G.; FINGER, F. L. Longevity and quality of Heliconia psittacorum x H. spathocircinata "Golden Torch" treated with 8-hydroxyquinoline citrate. In: INTERNATIONAL SYMPOSIUM ON POSTHARVEST QUALITY OF ORNAMENTAL PLANTS, 10., 2015, Porto de Galinhas. Porto de Galinhas : ACTA Horticulturae 1060, 2015. 187-192 Editores A. C. R. Castro, F. L. Cuquel, V. Loges| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroindústria de Alimentos. |
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| 15. | | PAWLOWSKI, E.; SOBUCKI, L.; BARBOSA, J. G. P.; HANDTE, V. G.; VIEIRA, I. B.; BRUNETTO, G.; MENDES, I. de C.; JACQUES, R. J. S. Relationships between yield, enzymatic activity, and chemical properties across different soil layers and phenological stages of grapevines in southern Brazil. Applied Soil Ecology, v. 204, 105732, Dec. 2024.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Cerrados. |
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| Registros recuperados : 15 | |
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