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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
08/06/2021 |
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Data da última atualização: |
10/06/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
FACCHINATTO, W. M.; GALANTE, J.; MESQUITA, L.; SILVA, D. S.; SANTOS, D. M. dos; MORAES, T. B.; CAMPANA-FILHO, S. P.; COLNAGO, L. A.; SARMENTO, B.; NEVES, J. das. |
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Afiliação: |
LUIZ ALBERTO COLNAGO, CNPDIA. |
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Título: |
Clotrimazole-loaded N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan nanoparticles for topical treatment of vulvovaginal candidiasis. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Acta Biomaterialia, v. 125, 2021. |
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Páginas: |
312?321 |
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ISSN: |
172-7061 |
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DOI: |
https://doi.org/10.1016/j.actbio.2021.02.029 |
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Idioma: |
Inglês |
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Conteúdo: |
Vulvovaginal candidiasis (VVC) represents a considerable health burden for women. Despite the availability of a significant array of antifungal drugs and topical products, the management of the infection is not always effective, and new approaches are needed. Here, we explored cationic N-(2-hydroxy)- propyl-3-trimethylammonium, O-palmitoyl chitosan nanoparticles (NPs) as carriers of clotrimazole (CLT) for the topical treatment of VVC. CLT-NPs with approximately 280 nm in diameter were obtained by selfassembly in water and subsequent stabilization by ionic crosslinking with tripolyphosphate. The nanosystem featured pH-independent sustained drug release up to 24 h, which affected both in vitro anti-Candida activity and cytotoxicity. The CLT-loaded nanostructured platform yielded favorable selectivity index values for a panel of standard strains and clinical isolates of Candida spp. and female genital tract cell lines (HEC-1-A, Ca Ski and HeLa), as compared to the free drug. CLT-NPs also improved in vitro drug permeability across HEC-1-A and Ca Ski cell monolayers, thus suggesting that the nanocarrier may provide higher mucosal tissue levels of the active compound. Overall, data support that CLT-NPs may be a valuable asset for the topical treatment of VVC. |
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Palavras-Chave: |
Health; Vaginal drug delivery; Women s health. |
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Categoria do assunto: |
-- |
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Marc: |
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001 2132239
005 2022-06-10
008 2021 bl uuuu u00u1 u #d
022 $a172-7061
024 7 $ahttps://doi.org/10.1016/j.actbio.2021.02.029$2DOI
100 1 $aFACCHINATTO, W. M.
245 $aClotrimazole-loaded N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan nanoparticles for topical treatment of vulvovaginal candidiasis.$h[electronic resource]
260 $c2021
300 $a312?321
520 $aVulvovaginal candidiasis (VVC) represents a considerable health burden for women. Despite the availability of a significant array of antifungal drugs and topical products, the management of the infection is not always effective, and new approaches are needed. Here, we explored cationic N-(2-hydroxy)- propyl-3-trimethylammonium, O-palmitoyl chitosan nanoparticles (NPs) as carriers of clotrimazole (CLT) for the topical treatment of VVC. CLT-NPs with approximately 280 nm in diameter were obtained by selfassembly in water and subsequent stabilization by ionic crosslinking with tripolyphosphate. The nanosystem featured pH-independent sustained drug release up to 24 h, which affected both in vitro anti-Candida activity and cytotoxicity. The CLT-loaded nanostructured platform yielded favorable selectivity index values for a panel of standard strains and clinical isolates of Candida spp. and female genital tract cell lines (HEC-1-A, Ca Ski and HeLa), as compared to the free drug. CLT-NPs also improved in vitro drug permeability across HEC-1-A and Ca Ski cell monolayers, thus suggesting that the nanocarrier may provide higher mucosal tissue levels of the active compound. Overall, data support that CLT-NPs may be a valuable asset for the topical treatment of VVC.
653 $aHealth
653 $aVaginal drug delivery
653 $aWomen s health
700 1 $aGALANTE, J.
700 1 $aMESQUITA, L.
700 1 $aSILVA, D. S.
700 1 $aSANTOS, D. M. dos
700 1 $aMORAES, T. B.
700 1 $aCAMPANA-FILHO, S. P.
700 1 $aCOLNAGO, L. A.
700 1 $aSARMENTO, B.
700 1 $aNEVES, J. das
773 $tActa Biomaterialia$gv. 125, 2021.
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| 1. |  | LIMA, E. B. de; BARROS, R. C. de; BALENSIFER, P. H. de M.; FERREIRA, M. A. J. F.; SILVA, A. F. Diversidade de variedades crioulas na 7° Feira de Troca de Sementes Crioulas do Agreste Meridional de Pernambuco. RG News, v. 9, n. 1, p. 136, 2023. Edição Especial do 6º Simpósio Rede de Recursos Genéticos Vegetais do Nordeste, Recife, Nov. 2023.| Tipo: Resumo em Anais de Congresso |
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