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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
28/08/2018 |
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Data da última atualização: |
03/01/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LOPES, P. D.; OKINO, C. H.; FERNANDO, F. S.; PAVANI, C.; CASAGRANDE, V. M.; LOPEZ, R. F. V.; MONTASSIER, M. F. de; MONTASSIER, H. J. |
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Afiliação: |
Priscila Diniz Lopes, UNESP; CINTIA HIROMI OKINO, CPPSE; Filipe Santos Fernando, UNESP; Caren Pavani, UNESP; Viviane Mariguela Casagrande, UNESP; Renata F. V. Lopez, USP; Maria de Fátima Silva Montassier, UNESP; Helio José Montassier, UNESP. |
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Título: |
Inactivated infectious bronchitis virus vaccine encapsulated in chitosan nanoparticles induces mucosal immune responses and effective protection against challenge. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Vaccine, v. 36, p. 2630-2636, abr. 2018. |
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Volume: |
36 |
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Idioma: |
Inglês |
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Conteúdo: |
Avian infectious bronchitis virus (IBV) is one of the most important viral diseases of poultry. The mucosa of upper respiratory tract, specially the trachea, is the primary replication site for this virus. However, conventional inactivate IBV vaccines usually elicit reduced mucosal immune responses and local protection. Thus, an inactivated IBV vaccine containing BR-I genotype strain encapsulated in chitosan nanoparticles (IBV-CS) was produced by ionic gelation method to be administered by oculo-nasal route to chickens. IBV-CS vaccine administered alone resulted in markedly mucosal immune responses, characterized by high levels of anti-IBV IgA isotype antibodies and IFNc gene expression at 1dpi. The association of live attenuated Massachusetts IBV and IBV-CS vaccine also induced strong mucosal immune responses, though a switch from IgA isotype to IgG was observed, and IFNc gene expression peak was late (at 5 dpi). Efficacy of IBV-CS was evaluated by tracheal ciliostasis analysis, histopathology examination, and viral load determination in the trachea and kidney. The results indicated that IBV-CS vaccine administered alone or associated with a live attenuated heterologous vaccine induced both humoral and cellmediated immune responses at the primary site of viral replication, and provided an effective protection against IBV infection at local (trachea) and systemic (kidney) sites. |
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Thesagro: |
Bronquite; Vacina; Vacina Inativada. |
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Thesaurus Nal: |
Inactivated vaccines; Infectious bronchitis; Infectious bronchitis virus; Mucosal immunity. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02347naa a2200313 a 4500
001 2094598
005 2019-01-03
008 2018 bl uuuu u00u1 u #d
100 1 $aLOPES, P. D.
245 $aInactivated infectious bronchitis virus vaccine encapsulated in chitosan nanoparticles induces mucosal immune responses and effective protection against challenge.$h[electronic resource]
260 $c2018
300 $a36
490 $v36
520 $aAvian infectious bronchitis virus (IBV) is one of the most important viral diseases of poultry. The mucosa of upper respiratory tract, specially the trachea, is the primary replication site for this virus. However, conventional inactivate IBV vaccines usually elicit reduced mucosal immune responses and local protection. Thus, an inactivated IBV vaccine containing BR-I genotype strain encapsulated in chitosan nanoparticles (IBV-CS) was produced by ionic gelation method to be administered by oculo-nasal route to chickens. IBV-CS vaccine administered alone resulted in markedly mucosal immune responses, characterized by high levels of anti-IBV IgA isotype antibodies and IFNc gene expression at 1dpi. The association of live attenuated Massachusetts IBV and IBV-CS vaccine also induced strong mucosal immune responses, though a switch from IgA isotype to IgG was observed, and IFNc gene expression peak was late (at 5 dpi). Efficacy of IBV-CS was evaluated by tracheal ciliostasis analysis, histopathology examination, and viral load determination in the trachea and kidney. The results indicated that IBV-CS vaccine administered alone or associated with a live attenuated heterologous vaccine induced both humoral and cellmediated immune responses at the primary site of viral replication, and provided an effective protection against IBV infection at local (trachea) and systemic (kidney) sites.
650 $aInactivated vaccines
650 $aInfectious bronchitis
650 $aInfectious bronchitis virus
650 $aMucosal immunity
650 $aBronquite
650 $aVacina
650 $aVacina Inativada
700 1 $aOKINO, C. H.
700 1 $aFERNANDO, F. S.
700 1 $aPAVANI, C.
700 1 $aCASAGRANDE, V. M.
700 1 $aLOPEZ, R. F. V.
700 1 $aMONTASSIER, M. F. de
700 1 $aMONTASSIER, H. J.
773 $tVaccine$gv. 36, p. 2630-2636, abr. 2018.
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Embrapa Pecuária Sudeste (CPPSE) |
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