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Registro Completo |
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
01/04/2016 |
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Data da última atualização: |
29/12/2017 |
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Autoria: |
ANDRADE, D. G. A.; DALANEZI, F. M.; TRECENTI, A. S.; CUNHA, P. H. J.; BORGES, A. S.; OLIVEIRA-FILHO, J. P. |
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Afiliação: |
DANILO G. A. ANDRADE, UNESP; FELIPE M. DALANEZI, UNESP; ANELIZE S. TRECENTI, UNESP; PAULO HENRIQUE J. CUNHA, UFG; ALEXANDRE S. BORGES, UNESP; JOSÉ P. OLIVEIRA-FILHO, UNESP. |
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Título: |
Prevalence study of SNP c.421G>T in the ADAMTS2 gene responsible for dermtosparaxis in white doper sheep in Brazil. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 36, n. 2, p. 73-76, fev. 2016. |
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Idioma: |
Inglês |
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Conteúdo: |
Dermatosparaxis is an autosomal recessive disorder of connective tissue; the disorder is clinically characterized by skin fragility and hyperextensibility. Dermatosparaxis in White Dorper sheep is caused by a single nucleotide polymorphism (SNP) (c.421G>T) in the ADAM metalloproteinase with thrombospondin type 1 motif, 2 (ADAMTS2) gene. The aim of this study was to investigate the prevalence of this SNP in a White Dorper herd in São Paulo state, Brazil. In this study, we collected blood DNA samples from 303 White Dorper sheep and performed polymerase chain reaction to amplify the SNP region. The samples were sequenced to determine the presence of the SNP in the ADAMTS2 gene. The SNP prevalence in the studied population was 15.5%; this finding indicates that more effective control measures should be used to prevent the inheritance of SNP c.421G>T in the ADAMTS2 gene in Brazilian White Dorper herds. |
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Palavras-Chave: |
Astênia cutânea; Autossômica recessiva; Cutaneous asthenia; White dorper. |
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Thesagro: |
Ovino. |
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Thesaurus Nal: |
Sheep. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/141915/1/Prevalence-study-of-SNP.pdf
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Marc: |
LEADER 01688naa a2200253 a 4500
001 2042370
005 2017-12-29
008 2016 bl uuuu u00u1 u #d
100 1 $aANDRADE, D. G. A.
245 $aPrevalence study of SNP c.421G>T in the ADAMTS2 gene responsible for dermtosparaxis in white doper sheep in Brazil.
260 $c2016
520 $aDermatosparaxis is an autosomal recessive disorder of connective tissue; the disorder is clinically characterized by skin fragility and hyperextensibility. Dermatosparaxis in White Dorper sheep is caused by a single nucleotide polymorphism (SNP) (c.421G>T) in the ADAM metalloproteinase with thrombospondin type 1 motif, 2 (ADAMTS2) gene. The aim of this study was to investigate the prevalence of this SNP in a White Dorper herd in São Paulo state, Brazil. In this study, we collected blood DNA samples from 303 White Dorper sheep and performed polymerase chain reaction to amplify the SNP region. The samples were sequenced to determine the presence of the SNP in the ADAMTS2 gene. The SNP prevalence in the studied population was 15.5%; this finding indicates that more effective control measures should be used to prevent the inheritance of SNP c.421G>T in the ADAMTS2 gene in Brazilian White Dorper herds.
650 $aSheep
650 $aOvino
653 $aAstênia cutânea
653 $aAutossômica recessiva
653 $aCutaneous asthenia
653 $aWhite dorper
700 1 $aDALANEZI, F. M.
700 1 $aTRECENTI, A. S.
700 1 $aCUNHA, P. H. J.
700 1 $aBORGES, A. S.
700 1 $aOLIVEIRA-FILHO, J. P.
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 36, n. 2, p. 73-76, fev. 2016.
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Embrapa Unidades Centrais (AI-SEDE) |
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