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| 101. |  | QUEIROZ, C. A. DE; MATOS, K. DA S.; LOBO, I. K. C.; SOUSA, S. B. DE; MUNIZ, C. R.; YAMAGISHI, M. E. B.; ZOCOLO, G. J.; HANADA, R. E.; GASPAROTTO, L.; SOUSA, N. R.; ANDRADE, E. V. DE; CORDEIRO, I. B.; MELO, A. A. M.; SILVA, G. F. da. Morpho-anatomical and molecular characterization of the oversprouting symptoms caused by Fusarium decemcellulare in Guarana plants (Paullinia cupana var. Sorbilis). Tropical Plant Biology, 2020. in Press| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Agroindústria Tropical; Embrapa Amazônia Ocidental. |
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| 102. | | TOLEDO, L. G. de; RAMOS, M. A. dos S.; SPÓSITO, L.; CASTILHO, E. M.; PAVAN, F. R.; LOPES, E. de O.; ZOCOLO, G. J.; SILVA, F. A. N.; RODRIGUES, T. H. S.; SANTOS, A. G. dos; BAUAB, T. M.; ALMEIDA, M. T. G. de. Essential oil of Cymbopogon nardus (L.) rendle: a strategy to combat fungal infections caused by Candida species. International Journal of Molecular Sciences, v. 17, n. 8, artigo nº 1252, 2016.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 103. | | ALCÂNTARA, D. B.; FERNANDES, T. S. M.; NASCIMENTO, H. O. do; LOPES, A. F.; MENEZES, M. G. G. de; LIMA, A. C. A.; CARVALHO, T. V.; GRINBERG P.; MILHOME, M. A. L.; OLIVEIRA, A. H. B.; BECKER, H.; ZOCOLO, G. J.; NASCIMENTO, R. F. Diagnostic detection systems and QuEChERS methods for multiclass pesticide analyses in different types of fruits: an overview from the last decade. Food Chemistry, London, v. 298, artigo 124958, 14 p., 15 Nov. 2019.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 104. | | REBOUÇAS, L. V.; OLIVEIRA, F. C. E.; PINHEIRO, D. P.; SILVA, M. F. S.; FERREIRA, V. P. G.; NICOLETE, R.; OLIVEIRA, A. C. A.; ALMEIDA, R. G.; SILVA JÚNIOR, E. N. DA; RIZZO, M. S.; COSTA, M. P.; ZOCOLO, G. J.; RIBEIRO, F. O. S.; SILVA, D. A. DA; CLAUDIA PESSOA. Liposomes containing 3-arylamino-nor-B-lapachone derivative: development, characterization, and in vitro evaluation of the cytotoxic activity. Journal of Drug Delivery Science and Technology, v. 62, April, 102348, 2021.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 105. | | CAMARA NETO, J. F.; CAMPELO, M. DA S.; CERQUEIRA, G. S.; MIRANDA. J. A. L. DE; GUEDES, J. A. C.; ALMEIDA, R. R. DE; SOARES, S. DE A.; GRAMOSA, N. V.; ZOCOLO, G. J.; VIEIRA, I. G. P.; RICARDO, N. M. P. S.; RIBEIRO, M. E. N. P. Gastroprotective effect of hydroalcoholic extract from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice. Journal of Ethnopharmacology, v. 292, 115191, 2022.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 106. | | GUEDES, J. A. C.; ALVES FILHO, E. DE G.; SILVA, M. F. S.; RODRIGUES, T. H. S.; RAMIRES, C. M. C.; LIMA, M. A. C. de; SILVA, G. S. DA; PESSOA, C. DO Ó; CANUTO, K. M.; BRITO, E. S. de; ALVES, R. E.; NASCIMENTO, R. F. DO; ZOCOLO, G. J. GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam. Journal of the Brazilian Chemical Society, Campinas, v. 31, n. 2, p. 331-340, 2020.| Biblioteca(s): Embrapa Agroindústria Tropical; Embrapa Semiárido. |
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| 107. | | PEREIRA JÚNIOR, L. C.; NASCIMENTO, F. G.; OLIVEIRA, S. R. B. D.; LIMA, G. C.; CHAGAS, F. D. S.; SOMBRA, V. G.; SORIANO, E. M.; SOUZA, M. H. L. P.; ZOCOLO, G. J.; SILVA, L. M. A.; PAULA, R. C. M. DE; DAMASCENO, R. O. S.; FREITAS, A. L. P. Protective effect against gastric mucosa injury of a sulfated agaran from Acanthophora spicifera. Carbohydrate Polymers, v. 261, art. no. 117829, 2021.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| 108. | | LIRA, S. M.; HOLANDA, M. O.; SILVA, J. Y. G. DA; MARQUES, C. G.; COELHO, L. C.; LIMA, C. L. S.; COSTA, J. T. G.; DANTAS, J. B.; MACIEL, G. L.; SILVA, G. S. DA; SANTOS, G. B. M.; ZOCOLO, G. J.; DIONISIO, A. P.; GUEDES, M. I. F. Pitaya [Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose] effect on glycemia and oxidative stress in aloxan-induced diabetic mice. Food Science and Technology, v. 43, e56822, 2023. 9 p.| Biblioteca(s): Embrapa Agroindústria Tropical; Embrapa Soja. |
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| 109. | | SILVA, M. F. S.; SILVA, L. M. A. e; QUINTELA, A. L.; SANTOS, A. G. DOS; SILVA, F. A. N.; OLIVEIRA, F. DE C. E. DE; ALVES FILHO, E. DE G.; BRITO, E. S. de; CANUTO, K. M.; PESSOA, CLAUDIA DO Ó; ZOCOLO, G. J. UPLC-HRMS and NMR applied in the evaluation of solid-phase extraction methods as a rational strategy of dereplication of Phyllanthus spp. aiming at the discovery of cytotoxic metabolites. Journal of Chromatography B, Amsterdam, v. 1120, p. 51-61, 1 July 2019.| Biblioteca(s): Embrapa Agroindústria Tropical. |
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| Registros recuperados : 109 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Mandioca e Fruticultura. Para informações adicionais entre em contato com cnpmf.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Mandioca e Fruticultura. |
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Data corrente: |
25/09/2018 |
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Data da última atualização: |
25/09/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
GUEDES, J. A. C.; ALVES FILHO, E. G.; RODRIGUES, T. H. S.; SILVA, M. F. S.; SOUZA, F. V. D.; SILVA, L. M. A. e; ALVES, R. E.; CANUTO, K. M.; BRITO, E. S. de; PESSOA, C. O.; NASCIMENTO, R. F.; ZOCOLO, G. J. |
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Afiliação: |
Jhonyson Arruda Carvalho Guedes, Universidade Federal do Ceará; Elenilson de Godoy Alves Filho, Embrapa Agroindústria Tropical (bolsista); TIGRESSA HELENA SOARES RODRIGUES, CNPAT; Maria Francilene Souza Silva, Universidade Federal do Ceará; FERNANDA VIDIGAL DUARTE SOUZA, CNPMF; LORENA MARA ALEXANDRE E SILVA, CNPAT; RICARDO ELESBAO ALVES, CNPAT; KIRLEY MARQUES CANUTO, CNPAT; EDY SOUSA DE BRITO, CNPAT; Cláudia do Ó Pessoa, Universidade Federal do Ceará; Ronaldo Ferreira Nascimento, Universidade Federal do Ceará; GUILHERME JULIAO ZOCOLO, CNPAT. |
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Título: |
Metabolic profile and cytotoxicity of non-polar extracts of pineapple leaves and chemometric analysis of different pineapple cultivars. I |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Industrial Crops and Products, v. 124, p. 466-474, 2018. |
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Idioma: |
Inglês |
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Conteúdo: |
The use of co-products from the fruit agroindustry as a source of bioactive molecules presents economic advantages, since these compounds are highly available and inexpensive. Therefore, the present study aimed to evaluate their qualitative chemical composition followed by multivariate analysis, and to correlate the results with those of the cytotoxicity tests. The non-polar metabolic profiles of the leaves of seven commercial pineapple (Ananas comosus (L.) Merr.) cultivars were investigated by using GC?MS. Twenty-seven metabolites were identified from the seven hexanic extracts. Multivariate analysis (Hierarchical Cluster Analysis, Principal Component Analysis and Partial Least Squares) revealed significant differences in the metabolic fingerprint of the different cultivars. Overall, the hexanic extracts of the seven cultivars of pineapple leaves showed promising antitumor activity against the six tumor lines tested (colon, leukemia, prostate, astrocytoma, breast and cervix). Correlation of the chemometric data, qualitative analysis, and cytotoxic tests allowed us to determine the possible biomarkers responsible for each specific antitumor activity. This study demonstrates a great valuation potential of a co-product little explored in the agroindustry of foods through the prospection of biologically active compounds. |
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Palavras-Chave: |
GC MS. |
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Thesagro: |
Abacaxi. |
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Thesaurus NAL: |
Ananas; Cytotoxicity; Multivariate analysis. |
|
Categoria do assunto: |
-- |
|
Marc: |
LEADER 02272naa a2200313 a 4500
001 2096234
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100 1 $aGUEDES, J. A. C.
245 $aMetabolic profile and cytotoxicity of non-polar extracts of pineapple leaves and chemometric analysis of different pineapple cultivars. I$h[electronic resource]
260 $c2018
520 $aThe use of co-products from the fruit agroindustry as a source of bioactive molecules presents economic advantages, since these compounds are highly available and inexpensive. Therefore, the present study aimed to evaluate their qualitative chemical composition followed by multivariate analysis, and to correlate the results with those of the cytotoxicity tests. The non-polar metabolic profiles of the leaves of seven commercial pineapple (Ananas comosus (L.) Merr.) cultivars were investigated by using GC?MS. Twenty-seven metabolites were identified from the seven hexanic extracts. Multivariate analysis (Hierarchical Cluster Analysis, Principal Component Analysis and Partial Least Squares) revealed significant differences in the metabolic fingerprint of the different cultivars. Overall, the hexanic extracts of the seven cultivars of pineapple leaves showed promising antitumor activity against the six tumor lines tested (colon, leukemia, prostate, astrocytoma, breast and cervix). Correlation of the chemometric data, qualitative analysis, and cytotoxic tests allowed us to determine the possible biomarkers responsible for each specific antitumor activity. This study demonstrates a great valuation potential of a co-product little explored in the agroindustry of foods through the prospection of biologically active compounds.
650 $aAnanas
650 $aCytotoxicity
650 $aMultivariate analysis
650 $aAbacaxi
653 $aGC MS
700 1 $aALVES FILHO, E. G.
700 1 $aRODRIGUES, T. H. S.
700 1 $aSILVA, M. F. S.
700 1 $aSOUZA, F. V. D.
700 1 $aSILVA, L. M. A. e
700 1 $aALVES, R. E.
700 1 $aCANUTO, K. M.
700 1 $aBRITO, E. S. de
700 1 $aPESSOA, C. O.
700 1 $aNASCIMENTO, R. F.
700 1 $aZOCOLO, G. J.
773 $tIndustrial Crops and Products$gv. 124, p. 466-474, 2018.
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