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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical. |
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Data corrente: |
07/01/2009 |
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Data da última atualização: |
15/06/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PAIVA, J. R. de; CAVALCANTI, J. J. V.; BARROS, L. de M.; CRISÓSTOMO, J. R.; LIMA, A. C.; CARDOSO, J. E.; MESQUITA, A. L. M.; MOSCA, J. L. |
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Afiliação: |
João Rodrigues de Paiva, CNPAT; José Jaime Vasconcelos Cavalcanti, CNPAT; Levi de Moura Barros, CNPAT; João Ribeiro Crisóstomo, CNPAT; Antonio Calixto Lima, CNPAT; José Emilson Cardoso, CNPAT; Antonio Lindemberg Martins Mesquita, CNPAT; José Luis Mosca, CNPAT. |
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Título: |
BRS 275 (BRS Dão): hybrid clone of dwarf x common or giant cashew. |
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Ano de publicação: |
2008 |
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Fonte/Imprenta: |
Crop Breeding and Applied Biotechnology, v.8, p.245-247, 2008. |
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Idioma: |
Inglês |
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Palavras-Chave: |
Annacardium occidentale; Commercial planting; Cultivar. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 00667naa a2200229 a 4500
001 1423104
005 2018-06-15
008 2008 bl uuuu u00u1 u #d
100 1 $aPAIVA, J. R. de
245 $aBRS 275 (BRS Dão)$bhybrid clone of dwarf x common or giant cashew.
260 $c2008
653 $aAnnacardium occidentale
653 $aCommercial planting
653 $aCultivar
700 1 $aCAVALCANTI, J. J. V.
700 1 $aBARROS, L. de M.
700 1 $aCRISÓSTOMO, J. R.
700 1 $aLIMA, A. C.
700 1 $aCARDOSO, J. E.
700 1 $aMESQUITA, A. L. M.
700 1 $aMOSCA, J. L.
773 $tCrop Breeding and Applied Biotechnology$gv.8, p.245-247, 2008.
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Registro original: |
Embrapa Agroindústria Tropical (CNPAT) |
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Registro Completo
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Biblioteca(s): |
Embrapa Pantanal. |
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Data corrente: |
19/07/2023 |
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Data da última atualização: |
19/07/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
NOGUEIRA, E.; TIRPÁK, F.; HAMILTON, L.; ZIGO, M.; KERNS, K.; SUTOVSKY, M.; KIM, J.; VOLKMANN, D.; JOVINE, L.; TAYLOR, J. F.; SCHNABEL, R. D.; SUTOVSKY, P. |
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Afiliação: |
ERIKLIS NOGUEIRA, CPAP; FILIP TIRPÁK, Slovak University of Agriculture; LAUREN HAMILTON, UNIVERISTY OF MISSOURI; MICHAL ZIGO, UNIVERSITY OF MISSOURI; KARL KERNS, UNIVERSITY OF MISSOURI; MIRIAM SUTOVSKY, UNIVERSITY OF MISSOURI; JAEWOO KIM, UNIVERSITY OF MISSOURI; DIETRICH VOLKMANN, UNIVERSITY OF MISSOURI; LUCA JOVINE, KAROLINSKA INSTITUTET; JEREMY F. TAYLOR, UNIVERSITY OF MISSOURI; ROBERT D. SCHNABEL, UNIVERSITY OF MISSOURI; PETER SUTOVSKY, UNIVERSITY OF MISSOURI. |
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Título: |
A Non-synonymous point mutation in a WD-40 domain repeat of EML5 leads to decreased bovine sperm quality and fertility. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Frontiers in Cell and Developmental Biology, v. 10, 872740, Apr. 2022. |
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ISSN: |
2296-634X |
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DOI: |
https://doi.org/10.3389/fcell.2022.872740 |
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Idioma: |
Inglês |
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Conteúdo: |
This study is part of a concerted effort to identify and phenotype rare, deleterious mutations that adversely affect sperm quality, or convey high developmental and fertility potential to embryos and ensuing progeny. A rare, homozygous mutation in EML5 (EML5R1654W), which encodes a microtubule-associated protein with high expression in testis and brain was identified in an Angus bull used extensively in artificial insemination (AI) for its outstanding progeny production traits. The bull?s fertility was low in cross-breeding timed AI (TAI) (Pregnancy/TAI = 25.2%; n = 222) and, in general, AI breeding to Nellore cows (41%; n = 822). A search of the 1,000 Bull Genomes Run9 database revealed an additional 74 heterozygous animals and 8 homozygous animals harboring this exact mutation across several different breeds (0.7% frequency within the 6,191 sequenced animals). Phenotypically, spermatozoa from the homozygous Angus bull displayed prominent piriform and tapered heads, and outwardly protruding knobbed acrosomes. Additionally, an increased retention of EML5 was also observed in the sperm head of both homozygous and heterozygous Angus bulls compared to wild-type animals. This non-synonymous point mutation is located within a WD40 signaling domain repeat of EML5 and is predicted to be detrimental to overall protein function by genomic single nucleotide polymorphism (SNP) analysis and protein modeling. Future work will examine how this rare mutation affects field AI fertility and will characterize the role of EML5 in spermatogenesis. MenosThis study is part of a concerted effort to identify and phenotype rare, deleterious mutations that adversely affect sperm quality, or convey high developmental and fertility potential to embryos and ensuing progeny. A rare, homozygous mutation in EML5 (EML5R1654W), which encodes a microtubule-associated protein with high expression in testis and brain was identified in an Angus bull used extensively in artificial insemination (AI) for its outstanding progeny production traits. The bull?s fertility was low in cross-breeding timed AI (TAI) (Pregnancy/TAI = 25.2%; n = 222) and, in general, AI breeding to Nellore cows (41%; n = 822). A search of the 1,000 Bull Genomes Run9 database revealed an additional 74 heterozygous animals and 8 homozygous animals harboring this exact mutation across several different breeds (0.7% frequency within the 6,191 sequenced animals). Phenotypically, spermatozoa from the homozygous Angus bull displayed prominent piriform and tapered heads, and outwardly protruding knobbed acrosomes. Additionally, an increased retention of EML5 was also observed in the sperm head of both homozygous and heterozygous Angus bulls compared to wild-type animals. This non-synonymous point mutation is located within a WD40 signaling domain repeat of EML5 and is predicted to be detrimental to overall protein function by genomic single nucleotide polymorphism (SNP) analysis and protein modeling. Future work will examine how this rare mutation affects field AI fertility and ... Mostrar Tudo |
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Thesagro: |
Espermatozóide; Fertilidade Animal. |
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Thesaurus NAL: |
Acrosome; Animal fertility; Biogenesis; Fertilization (reproduction); Spermatozoa; Spermiogenesis. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1155065/1/fcell-2022.pdf
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Marc: |
LEADER 02641naa a2200373 a 4500
001 2155065
005 2023-07-19
008 2022 bl uuuu u00u1 u #d
022 $a2296-634X
024 7 $ahttps://doi.org/10.3389/fcell.2022.872740$2DOI
100 1 $aNOGUEIRA, E.
245 $aA Non-synonymous point mutation in a WD-40 domain repeat of EML5 leads to decreased bovine sperm quality and fertility.$h[electronic resource]
260 $c2022
520 $aThis study is part of a concerted effort to identify and phenotype rare, deleterious mutations that adversely affect sperm quality, or convey high developmental and fertility potential to embryos and ensuing progeny. A rare, homozygous mutation in EML5 (EML5R1654W), which encodes a microtubule-associated protein with high expression in testis and brain was identified in an Angus bull used extensively in artificial insemination (AI) for its outstanding progeny production traits. The bull?s fertility was low in cross-breeding timed AI (TAI) (Pregnancy/TAI = 25.2%; n = 222) and, in general, AI breeding to Nellore cows (41%; n = 822). A search of the 1,000 Bull Genomes Run9 database revealed an additional 74 heterozygous animals and 8 homozygous animals harboring this exact mutation across several different breeds (0.7% frequency within the 6,191 sequenced animals). Phenotypically, spermatozoa from the homozygous Angus bull displayed prominent piriform and tapered heads, and outwardly protruding knobbed acrosomes. Additionally, an increased retention of EML5 was also observed in the sperm head of both homozygous and heterozygous Angus bulls compared to wild-type animals. This non-synonymous point mutation is located within a WD40 signaling domain repeat of EML5 and is predicted to be detrimental to overall protein function by genomic single nucleotide polymorphism (SNP) analysis and protein modeling. Future work will examine how this rare mutation affects field AI fertility and will characterize the role of EML5 in spermatogenesis.
650 $aAcrosome
650 $aAnimal fertility
650 $aBiogenesis
650 $aFertilization (reproduction)
650 $aSpermatozoa
650 $aSpermiogenesis
650 $aEspermatozóide
650 $aFertilidade Animal
700 1 $aTIRPÁK, F.
700 1 $aHAMILTON, L.
700 1 $aZIGO, M.
700 1 $aKERNS, K.
700 1 $aSUTOVSKY, M.
700 1 $aKIM, J.
700 1 $aVOLKMANN, D.
700 1 $aJOVINE, L.
700 1 $aTAYLOR, J. F.
700 1 $aSCHNABEL, R. D.
700 1 $aSUTOVSKY, P.
773 $tFrontiers in Cell and Developmental Biology$gv. 10, 872740, Apr. 2022.
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Embrapa Pantanal (CPAP) |
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