Data/hora: 20/06/2024 02:47:45

Biblioteca(s): 	Embrapa Agricultura Digital.	
Tipo da produção científica: 	Resumo em Anais de Congresso	
Data corrente: 	15/01/2016	
Data da última atualização: 	21/01/2020	
Autoria: 	SILVA, J. M. da; ROMANIUC, A. R.; CAETANO, A. R.; GIACHETTO, P. F.; YAMAGISHI, M. E. B.	
Afiliação: 	JOAQUIM MANOEL DA SILVA, Unemat; ALAN ROBERTO ROMANIUC, CNPTIA; ALEXANDRE RODRIGUES CAETANO, CENARGEN; POLIANA FERNANDA GIACHETTO, CNPTIA; MICHEL EDUARDO BELEZA YAMAGISHI, CNPTIA.	
Título: 	Java Merging Copy Number Variants (JM-CNV): a new algorithm for identifying Copy Number Variant Regions (CNVR).	
Ano de publicação: 	2015	
Fonte/Imprenta: 	In: PLANT & ANIMAL GENOME CONFERENCE, 23., 2015, San Diego, CA. [Abstracts...]. San Diego: [s.n.], 2015.	
Páginas: 	Não paginado.	
Idioma: 	Inglês	
Notas: 	PAG 2015. Pôster P1170.	
Conteúdo: 	CNVs (Copy Number Variations) are defined as copy number variations of DNA fragments typically larger than one kilobase (Kb), but less than five megabases (Mb). They represent a genomic disequilibrium that alters the ploidy in a specific locus within an individual, which may also be observed with varying frequencies within a population. An initial study estimated that 12% of the human genome shows this type of structural variation. Reliable tools have been developed to detect CNVs from molecular data produced with three main platforms: Comparative Genomic Hybridization (CGH) arrays, Single Nucleotide Polymorphism (SNP) genotyping arrays, and DNA Next-Generation Sequencing (NGS). However, processes for merging overlapping CNVs into a meaningful set of discrete Copy Number Variable Regions (CNVRs) need improvement, particularly when several CNV patterns co-exist within the same genomic locus. Available algorithms frequently merge noncontiguous CNVRs or fragment large CNVRs into multiple regions. A new web-based software (Java Merging Copy Number Variants: JM-CNV) was developed to address the aforementioned issues.	
Palavras-Chave: 	Bioinformática; Copy Number Variations.	
Thesaurus Nal: 	Bioinformatics; Computer software.	
Categoria do assunto: 	X Pesquisa, Tecnologia e Engenharia	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/item/137048/1/Java-Silva-PAG.pdf	
Registro original: 	Embrapa Agricultura Digital (CNPTIA)	
Exemplares: 	CNPTIA - (18586-1) - UPC - RA - DD -  -  -  - DIS