Data/hora: 21/09/2024 08:26:33

Biblioteca(s): 	Embrapa Gado de Leite.	
Data corrente: 	19/02/2016	
Data da última atualização: 	03/02/2024	
Autoria: 	SILVA, A. P. C.; MACÊDO, A. A.; SILVA, T. M. A.; XIMENES, L. C. A.; BRANDAO, H. de M.; PAIXÃO, T. A.; SANTOS, R. L.	
Afiliação: 	Ana Patrícia C. Silva, UFMG; Auricélio A. Macêdo, UFMG; Teane M. A. Silva, UFMG; Luana C. A. Ximenes, UFMG; HUMBERTO DE MELLO BRANDAO, CNPGL; Tatiane A. Paixão, UFMG; Renato L. Santos, UFMG.	
Título: 	Protection Provided by an Encapsulated Live Attenuated ΔabcBA Strain of Brucella ovis against Experimental Challenge in a Murine Model.	
Ano de publicação: 	2015	
Fonte/Imprenta: 	Clinical and Vaccine Immunology, v. 22, n. 7, p. 789-973, 2015.	
Idioma: 	Inglês	
Conteúdo: 	This study aimed to evaluate the Brucella ovis &#916;abcBA strain as a vaccine candidate in the murine model. BALB/c mice were subcutaneously or intraperitoneally immunized with a single dose or three doses of the B. ovis &#916;abcBA strain and then were challenged with wild-type B. ovis. Single or multiple immunizations provided only mild protection, with significantly smaller numbers of wild-type B. ovis CFU in the livers of immunized mice but not in the spleens. Encapsulation of B. ovis &#916;abcBA significantly improved protection against experimental challenges in both BALB/c and C57BL/6 mice. Furthermore, immunization with encapsulated B. ovis &#916;abcBA markedly prevented lesions in the spleens and livers of experimentally challenged mice. These results demonstrated that the encapsulated B. ovis &#916;abcBA strain confers protection to mice; therefore, this strain has potential as a vaccine candidate for rams.	
Palavras-Chave: 	Vaccine.	
Thesaurus Nal: 	animal health.	
Categoria do assunto: 	L Ciência Animal e Produtos de Origem Animal	
Registro original: 	Embrapa Gado de Leite (CNPGL)	
Exemplares: 	CNPGL - (22381-1) - UPC - AP - DD -  -  -  - DIS