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| Registros recuperados : 27 | |
| 21. |  | CAMPOS, B. M.; CARMO, A. S. do; EGITO, A. A. do; MARIANTE, A. da S.; ALBUQUERQUE, M. S. M. do; GOUVEIA, J. J. S. de; MALHADO, C. H. M.; VERARDO, L. L.; SILVA, M. V. G. B. da; CARNEIRO, P. L. S. Genetic diversity, population structure, and correlations between locally adapted zebu and taurine breeds in Brazil using SNP markers. Tropical Animal Health and Production, v. 49, n. 8, p 1677-1684, 2017.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia. |
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| 22. | | PAIXÃO, D. M.; CARNEIRO, P. L. S.; PAIVA, S. R.; SOUSA, K. R. S.; VERARDO, L. L.; BRACCINI NETO, J.; PINTO, A. P. G.; HIDALGO, A. M.; NASCIMENTO, C. S. do; PÉRISSÉ, I. V.; LOPES, P. S.; GUIMARÃES, S. E. F. Mapeamento de QTL nos cromossomos 1, 2, 3, 12, 14, 15 e X em suínos: características de carcaça e qualidade de carne. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 64, n. 4, p. 974-982, 2012.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 23. | | SILVA, M. V. G. B.; MARTINS, M. F.; CEMBRANELLI, M. de A. R.; PAIVA, L. DE C.; PANETTO, J. C. do C.; MACHADO, M. A.; VERARDO, L. L.; GONÇALVES, G. S.; REIS, D. R. de L.; MENDONÇA JÚNIOR, C. F.; BRAGA, F. do A.; FRANZON, C. de A. Programa de melhoramento genético da raça Girolando - Avaliação genômica de fêmeas jovens - junho/2017. Juiz de Fora: Embrapa Gado de Leite, 2017. 20 p. (Embrapa Gado de Leite. Documentos, 205)| Biblioteca(s): Embrapa Gado de Leite. |
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| 24. | | VIEIRA, J. I. G.; BRAGA, L. G.; CHU, T. C. S.; FERREIRA, P. H.; GUIMARÃES, S. E. F.; MARTINS, M. F.; PANETTO, J. C. do C.; MACHADO, M. A.; SILVA, D. B. dos S.; BONAFÉ, C. M.; MAGALHÃES, A. F. B.; SILVA, M. V. G. B.; VERARDO, L. L. Resequencing of Brazilian locally adapted cattle breeds revealed variants in candidate genes and transcription factors for meat fatty acid profile. Journal of Animal Breeding and Genetics, 2024. First online.| Biblioteca(s): Embrapa Gado de Leite. |
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| 25. | | SILVA, M. V. G. B.; MARTINS, M. F.; CEMBRANELLI, M. DE A. R.; PAIVA, L. DE C.; PANETTO, J. C. do C.; MACHADO, M. A.; VERARDO, L. L.; GONÇALVES, G. S.; REIS, D. R. de L.; ALVES, B. R. C. (ed.). Girolando breed genetic improvement program - Sire summary - Progeny test results - June 2017. Juiz de Fora: Embrapa Gado de Leite, 2017 55 p. (Embrapa Gado de Leite. Documentos, 206)| Biblioteca(s): Embrapa Gado de Leite. |
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| 26. | | NASCIMENTO, C. S.; PEIXOTO, J. de O.; VERARDO, L. L.; CAMPOS, C. F.; WELLER, M. M. DEL C. A.; FARIA, V. R.; BOTELHO, M. E.; MARTINS, M. F.; MACHADO, M. A.; SILVA, F. F.; LOPES, S. E. F.; GUIMARÂES. S. E. F. Transcript profiling of expressed sequence tags from semimembranosus muscle of commercial and naturalized pig breeds. Genetics and molecular research, n. 11 (AOP), 2012. Projeto: 02.10.06.003| Biblioteca(s): Embrapa Suínos e Aves. |
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| 27. | | OTTO, P. I.; GUIMARÃES, S. E. F.; VERARDO, L. L.; AZEVEDO, A. L. S.; VANDENPLAS, J.; SOARES, A. C. C.; SEVILLANO, C. A.; VERONEZE R; PIRES, M. de F. A.; FREITAS, C. de; PRATA, M. C. de A.; FURLONG, J.; VERNEQUE, R. da S.; MARTINS, M. F.; PANETTO, J. C. do C.; CARVALHO, W. A.; GOBO, D. O. R.; SILVA, M. V. G. B.; MACHADO, M. A. Genome-wide association studies for tick resistance in Bos taurus × Bos indicus crossbred cattle: A deeper look into this intricate mechanism. Journal of Dairy Science, v. 101, n. 12, p. 11020-11032, 2018.| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 27 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
09/01/2020 |
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Data da última atualização: |
06/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
OTTO, P. I.; GUIMARÃES, S. E. F.; VERARDO, L. L.; AZEVEDO, A. L. S.; VANDENPLAS, J.; SEVILLANO, C. A.; MARQUES, D. B. D.; PIRES, M. de F. A.; FREITAS, C. de; VERNEQUE, R. da S.; MARTINS, M. F.; PANETTO, J. C. do C.; CARVALHO, W. A.; GOBO, D. O. R.; SILVA, M. V. G. B.; MACHADO, M. A. |
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Afiliação: |
ANA LUISA SOUSA AZEVEDO, CNPGL; MARIA DE FATIMA AVILA PIRES, CNPGL; CELIO DE FREITAS, CNPGL; RUI DA SILVA VERNEQUE, CNPGL; MARTA FONSECA MARTINS, CNPGL; JOAO CLAUDIO DO CARMO PANETTO, CNPGL; WANESSA ARAUJO CARVALHO, CNPGL; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; MARCO ANTONIO MACHADO, CNPGL. |
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Título: |
Genome-wide association studies for heat stress response in Bos taurus × Bos indicus crossbred cattle. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Journal of Dairy Science, v. 102, n. 9, p. 8148-8158, 2019. |
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DOI: |
https://doi.org/10.3168/jds.2018-15305 |
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Idioma: |
Inglês |
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Conteúdo: |
Heat stress is an important issue in the global dairy industry. In tropical areas, an alternative to overcome heat stress is the use of crossbred animals or synthetic breeds, such as the Girolando. In this study, we performed a genome-wide association study (GWAS) and post-GWAS analyses for heat stress in an experimental Gir × Holstein F2 population. Rectal temperature (RT) was measured in heat-stressed F2 animals, and the variation between 2 consecutive RT measurements (ΔRT) was used as the dependent variable. Illumina BovineSNP50v1 BeadChip (Illumina Inc., San Diego, CA) and single-SNP approach were used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene-transcription factor (TF) networks, generated from enriched TF. The breed origin of marker alleles in the F2 population was assigned using the breed of origin of alleles (BOA) approach. Heritability and repeatability estimates (± standard error) for ΔRT were 0.13 ± 0.08 and 0.29 ± 0.06, respectively. Association analysis revealed 6 SNP significantly associated with ΔRT. Genes involved with biological processes in response to heat stress effects (LIF, OSM, TXNRD2, and DGCR8) were identified as putative candidate genes. After performing the BOA approach, the 10% of F2 animals with the lowest breeding values for ΔRT were classified as low-ΔRT, and the 10% with the highest breeding values for ΔRT were classified as high-ΔRT. On average, 49.4% of low-ΔRT animals had 2 alleles from the Holstein breed (HH), and 39% had both alleles from the Gir breed (GG). In high-ΔRT animals, the average proportion of animals for HH and GG were 1.4 and 50.2%, respectively. This study allowed the identification of candidate genes for ΔRT in Gir × Holstein crossbred animals. According to the BOA approach, Holstein breed alleles could be associated with better response to heat stress effects, which could be explained by the fact that Holstein animals are more affected by heat stress than Gir animals and thus require a genetic architecture to defend the body from the deleterious effects of heat stress. Future studies can provide further knowledge to uncover the genetic architecture underlying heat stress in crossbred cattle. MenosHeat stress is an important issue in the global dairy industry. In tropical areas, an alternative to overcome heat stress is the use of crossbred animals or synthetic breeds, such as the Girolando. In this study, we performed a genome-wide association study (GWAS) and post-GWAS analyses for heat stress in an experimental Gir × Holstein F2 population. Rectal temperature (RT) was measured in heat-stressed F2 animals, and the variation between 2 consecutive RT measurements (ΔRT) was used as the dependent variable. Illumina BovineSNP50v1 BeadChip (Illumina Inc., San Diego, CA) and single-SNP approach were used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene-transcription factor (TF) networks, generated from enriched TF. The breed origin of marker alleles in the F2 population was assigned using the breed of origin of alleles (BOA) approach. Heritability and repeatability estimates (± standard error) for ΔRT were 0.13 ± 0.08 and 0.29 ± 0.06, respectively. Association analysis revealed 6 SNP significantly associated with ΔRT. Genes involved with biological processes in response to heat stress effects (LIF, OSM, TXNRD2, and DGCR8) were identified as putative candidate genes. After performing the BOA approach, the 10% of F2 animals with the lowest breeding values for ΔRT were classified as low-ΔRT, and the 10% with the highest breeding values for ΔRT were classified as high-ΔRT. On average, 49.4% of low-ΔR... Mostrar Tudo |
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Palavras-Chave: |
Crossbred cattle; Gene network; Post-GWAS analyses. |
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Thesaurus NAL: |
Heat stress. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03369naa a2200361 a 4500
001 2118465
005 2024-02-06
008 2019 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3168/jds.2018-15305$2DOI
100 1 $aOTTO, P. I.
245 $aGenome-wide association studies for heat stress response in Bos taurus × Bos indicus crossbred cattle.$h[electronic resource]
260 $c2019
520 $aHeat stress is an important issue in the global dairy industry. In tropical areas, an alternative to overcome heat stress is the use of crossbred animals or synthetic breeds, such as the Girolando. In this study, we performed a genome-wide association study (GWAS) and post-GWAS analyses for heat stress in an experimental Gir × Holstein F2 population. Rectal temperature (RT) was measured in heat-stressed F2 animals, and the variation between 2 consecutive RT measurements (ΔRT) was used as the dependent variable. Illumina BovineSNP50v1 BeadChip (Illumina Inc., San Diego, CA) and single-SNP approach were used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene-transcription factor (TF) networks, generated from enriched TF. The breed origin of marker alleles in the F2 population was assigned using the breed of origin of alleles (BOA) approach. Heritability and repeatability estimates (± standard error) for ΔRT were 0.13 ± 0.08 and 0.29 ± 0.06, respectively. Association analysis revealed 6 SNP significantly associated with ΔRT. Genes involved with biological processes in response to heat stress effects (LIF, OSM, TXNRD2, and DGCR8) were identified as putative candidate genes. After performing the BOA approach, the 10% of F2 animals with the lowest breeding values for ΔRT were classified as low-ΔRT, and the 10% with the highest breeding values for ΔRT were classified as high-ΔRT. On average, 49.4% of low-ΔRT animals had 2 alleles from the Holstein breed (HH), and 39% had both alleles from the Gir breed (GG). In high-ΔRT animals, the average proportion of animals for HH and GG were 1.4 and 50.2%, respectively. This study allowed the identification of candidate genes for ΔRT in Gir × Holstein crossbred animals. According to the BOA approach, Holstein breed alleles could be associated with better response to heat stress effects, which could be explained by the fact that Holstein animals are more affected by heat stress than Gir animals and thus require a genetic architecture to defend the body from the deleterious effects of heat stress. Future studies can provide further knowledge to uncover the genetic architecture underlying heat stress in crossbred cattle.
650 $aHeat stress
653 $aCrossbred cattle
653 $aGene network
653 $aPost-GWAS analyses
700 1 $aGUIMARÃES, S. E. F.
700 1 $aVERARDO, L. L.
700 1 $aAZEVEDO, A. L. S.
700 1 $aVANDENPLAS, J.
700 1 $aSEVILLANO, C. A.
700 1 $aMARQUES, D. B. D.
700 1 $aPIRES, M. de F. A.
700 1 $aFREITAS, C. de
700 1 $aVERNEQUE, R. da S.
700 1 $aMARTINS, M. F.
700 1 $aPANETTO, J. C. do C.
700 1 $aCARVALHO, W. A.
700 1 $aGOBO, D. O. R.
700 1 $aSILVA, M. V. G. B.
700 1 $aMACHADO, M. A.
773 $tJournal of Dairy Science$gv. 102, n. 9, p. 8148-8158, 2019.
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