| |
|
|
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia. |
|
Data corrente: |
04/10/2011 |
|
Data da última atualização: |
16/02/2023 |
|
Tipo da produção científica: |
Resumo em Anais de Congresso |
|
Autoria: |
GRATTAPAGLIA, D.; RESENDE, M. D. V. de; RESENDE, M. F. R.; SANSALONI, C. P.; PETROLI, C. D.; MISSIAGGIA, A. A.; TAKAHASHI, E. K.; ZAMPROGNO, K. C.; KILIAN, A. |
|
Afiliação: |
DARIO GRATTAPAGLIA, CENARGEN; MARCOS DEON VILELA DE RESENDE, CNPF; Marcio F. R. Resende, UFV; Carolina P. Sansaloni, UnB; Cesar D. Petroli, UnB; Alexandre A. Missiaggia, FIBRIA; Elisabete K. Takahashi, CENIBRA; Karina C. Zamprogno, VERACEL; Andrzej Kilian, DArT - Diversity Arrays Technology. |
|
Título: |
High realized accuracies of genomic selection for volume growth and wood density in Eucalyptus breeding populations with contrasting effective sizes. |
|
Ano de publicação: |
2011 |
|
Fonte/Imprenta: |
In: PLANT & ANIMAL GENOMES CONFERENCE, 19., 2011, San Diego. Conference... [S.l.]: International Plant & Animal Genome, 2011. |
|
Idioma: |
Inglês |
|
Notas: |
Abstract. W235: Forest Trees. |
|
Conteúdo: |
Genomic Selection (GS) will likely cause a paradigm shift in tree breeding due to the prospects of radically increasing gain per unit time and improving selection accuracy. Deterministic simulations show GEBV (Genome Estimated Breeding Values) accuracies matching or exceeding phenotypic BLUP-based-accuracy (0.68) even with low-density marker panels (2-3 markers/centiMorgan) in breeding populations with effective sizes Ne ? 60. Furthermore, a GS-based reduction in breeding cycle time by 50% should provide a gain ?100% in selection efficiency for low heritability traits (Grattapaglia&Resende, 2010; DOI: 10.1007/s11295-010-0328-4). We now report on experimentally realized accuracies of GS for three key traits in Eucalyptus in two breeding populations (CEN and FIB) with contrasting effective sizes (Ne= 11 and Ne= 120). Genotypes at ~3,500 DArT markers and de-regressed phenotypes for Height (H), Diameter at Breast Height (DBH) and wood density (WD) (age 4yr.) were obtained for 783 and 920 random trees from CEN and FIB respectively. Sets of 700 and 838 trees for CEN and FIB were used for training and the remaining trees for validation in a jackknifing scheme. Realized GEBV accuracies for H, DBH and WD were 0.67,0.69 and 0.54 for CEN and 0.62,0.54 and 0.53 for FIB respectively. Accuracies matched and slightly surpassed expectations from simulations for FIB, possibly due to its hybrid composition. GEBV accuracies were low (zero to 0.18) across populations suggesting that population specific GS models will be necessary. These are the first experimental results of GS in forest trees and among the first public ones in plant breeding. MenosGenomic Selection (GS) will likely cause a paradigm shift in tree breeding due to the prospects of radically increasing gain per unit time and improving selection accuracy. Deterministic simulations show GEBV (Genome Estimated Breeding Values) accuracies matching or exceeding phenotypic BLUP-based-accuracy (0.68) even with low-density marker panels (2-3 markers/centiMorgan) in breeding populations with effective sizes Ne ? 60. Furthermore, a GS-based reduction in breeding cycle time by 50% should provide a gain ?100% in selection efficiency for low heritability traits (Grattapaglia&Resende, 2010; DOI: 10.1007/s11295-010-0328-4). We now report on experimentally realized accuracies of GS for three key traits in Eucalyptus in two breeding populations (CEN and FIB) with contrasting effective sizes (Ne= 11 and Ne= 120). Genotypes at ~3,500 DArT markers and de-regressed phenotypes for Height (H), Diameter at Breast Height (DBH) and wood density (WD) (age 4yr.) were obtained for 783 and 920 random trees from CEN and FIB respectively. Sets of 700 and 838 trees for CEN and FIB were used for training and the remaining trees for validation in a jackknifing scheme. Realized GEBV accuracies for H, DBH and WD were 0.67,0.69 and 0.54 for CEN and 0.62,0.54 and 0.53 for FIB respectively. Accuracies matched and slightly surpassed expectations from simulations for FIB, possibly due to its hybrid composition. GEBV accuracies were low (zero to 0.18) across populations suggesting that population ... Mostrar Tudo |
|
Palavras-Chave: |
Melhoramento genético; Seleção genômica. |
|
Thesaurus Nal: |
Eucalyptus. |
|
Categoria do assunto: |
-- |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/40976/1/2011-RAC-M.Deon-PAG-XIX-HighRealized-1.pdf
|
|
Marc: |
LEADER 02562nam a2200253 a 4500
001 1902325
005 2023-02-16
008 2011 bl uuuu u01u1 u #d
100 1 $aGRATTAPAGLIA, D.
245 $aHigh realized accuracies of genomic selection for volume growth and wood density in Eucalyptus breeding populations with contrasting effective sizes.$h[electronic resource]
260 $aIn: PLANT & ANIMAL GENOMES CONFERENCE, 19., 2011, San Diego. Conference... [S.l.]: International Plant & Animal Genome$c2011
500 $aAbstract. W235: Forest Trees.
520 $aGenomic Selection (GS) will likely cause a paradigm shift in tree breeding due to the prospects of radically increasing gain per unit time and improving selection accuracy. Deterministic simulations show GEBV (Genome Estimated Breeding Values) accuracies matching or exceeding phenotypic BLUP-based-accuracy (0.68) even with low-density marker panels (2-3 markers/centiMorgan) in breeding populations with effective sizes Ne ? 60. Furthermore, a GS-based reduction in breeding cycle time by 50% should provide a gain ?100% in selection efficiency for low heritability traits (Grattapaglia&Resende, 2010; DOI: 10.1007/s11295-010-0328-4). We now report on experimentally realized accuracies of GS for three key traits in Eucalyptus in two breeding populations (CEN and FIB) with contrasting effective sizes (Ne= 11 and Ne= 120). Genotypes at ~3,500 DArT markers and de-regressed phenotypes for Height (H), Diameter at Breast Height (DBH) and wood density (WD) (age 4yr.) were obtained for 783 and 920 random trees from CEN and FIB respectively. Sets of 700 and 838 trees for CEN and FIB were used for training and the remaining trees for validation in a jackknifing scheme. Realized GEBV accuracies for H, DBH and WD were 0.67,0.69 and 0.54 for CEN and 0.62,0.54 and 0.53 for FIB respectively. Accuracies matched and slightly surpassed expectations from simulations for FIB, possibly due to its hybrid composition. GEBV accuracies were low (zero to 0.18) across populations suggesting that population specific GS models will be necessary. These are the first experimental results of GS in forest trees and among the first public ones in plant breeding.
650 $aEucalyptus
653 $aMelhoramento genético
653 $aSeleção genômica
700 1 $aRESENDE, M. D. V. de
700 1 $aRESENDE, M. F. R.
700 1 $aSANSALONI, C. P.
700 1 $aPETROLI, C. D.
700 1 $aMISSIAGGIA, A. A.
700 1 $aTAKAHASHI, E. K.
700 1 $aZAMPROGNO, K. C.
700 1 $aKILIAN, A.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Recursos Genéticos e Biotecnologia (CENARGEN) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria de Alimentos. Para informações adicionais entre em contato com ctaa.biblioteca@embrapa.br. |
Registro Completo
|
Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
|
Data corrente: |
10/10/2017 |
|
Data da última atualização: |
10/10/2017 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Circulação/Nível: |
A - 2 |
|
Autoria: |
SILVA, E. R. DA; BIZZO, H. R.; FERNANDES, P. D.; VEIGA JUNIOR, V. F. DA; LEITÃO, S. G.; OLIVEIRA, D. R. DE. |
|
Afiliação: |
EDUARDO R. DA SILVA, UFRJ; HUMBERTO RIBEIRO BIZZO, CTAA; PATRÍCIA D. FERNANDES, UFRJ; VALDIR F. DA VEIGA JUNIOR, UFA; SUZANA G. LEITÃO, UFRJ; DANILO R. DE OLIVEIRA, UFRJ. |
|
Título: |
Development and evaluation of an inhalation chamber for in vivo tests. |
|
Ano de publicação: |
2017 |
|
Fonte/Imprenta: |
Anais da Academia Brasileira de Ciências, v. 89, n. 3, p. 1643-1653, 2017. |
|
Idioma: |
Inglês |
|
Conteúdo: |
The bioavailability, toxicity, and therapeutic efficacy of a drug is directly related to its administration route. The pulmonary route can be accessed by inhalation after fumigation, vaporization or nebulization. Thus, pharmacological and toxicological evaluation accessed by an apparatus specifically designed and validated for this type of administration is extremely important. Based on pre-existing models, an inhalation chamber was developed. This presents a central structure with five animal holders. The nebulized air passes directly and continuously through these holders and subsequently to an outlet. Evaluation of its operation was performed using clove essential oil, a nebulizer, and a flow meter. The air within the chamber was collected by static headspace and analyzed by gas chromatography with a flame ionization detector. For this purpose, a 2.5 minutes chromatographic method was developed. The air flow in each of the five outputs was 0.92 liters per minute. During the first minute, the chamber became saturated with the nebulized material. Homogeneous and continuous operation of the chamber was observed without accumulation of volatile material inside it for 25 minutes. The inhalation chamber works satisfactorily for in vivo tests with medicines designed to be administrated by inhalation. |
|
Palavras-Chave: |
Biological activities; Gas chromatograph; Headspace; Inhalation chamber. |
|
Thesagro: |
Syzygium Aromaticum. |
|
Thesaurus NAL: |
Gas chromatography; Headspace analysis. |
|
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
|
Marc: |
LEADER 02117naa a2200265 a 4500
001 2077098
005 2017-10-10
008 2017 bl uuuu u00u1 u #d
100 1 $aSILVA, E. R. DA
245 $aDevelopment and evaluation of an inhalation chamber for in vivo tests.$h[electronic resource]
260 $c2017
520 $aThe bioavailability, toxicity, and therapeutic efficacy of a drug is directly related to its administration route. The pulmonary route can be accessed by inhalation after fumigation, vaporization or nebulization. Thus, pharmacological and toxicological evaluation accessed by an apparatus specifically designed and validated for this type of administration is extremely important. Based on pre-existing models, an inhalation chamber was developed. This presents a central structure with five animal holders. The nebulized air passes directly and continuously through these holders and subsequently to an outlet. Evaluation of its operation was performed using clove essential oil, a nebulizer, and a flow meter. The air within the chamber was collected by static headspace and analyzed by gas chromatography with a flame ionization detector. For this purpose, a 2.5 minutes chromatographic method was developed. The air flow in each of the five outputs was 0.92 liters per minute. During the first minute, the chamber became saturated with the nebulized material. Homogeneous and continuous operation of the chamber was observed without accumulation of volatile material inside it for 25 minutes. The inhalation chamber works satisfactorily for in vivo tests with medicines designed to be administrated by inhalation.
650 $aGas chromatography
650 $aHeadspace analysis
650 $aSyzygium Aromaticum
653 $aBiological activities
653 $aGas chromatograph
653 $aHeadspace
653 $aInhalation chamber
700 1 $aBIZZO, H. R.
700 1 $aFERNANDES, P. D.
700 1 $aVEIGA JUNIOR, V. F. DA
700 1 $aLEITÃO, S. G.
700 1 $aOLIVEIRA, D. R. DE
773 $tAnais da Academia Brasileira de Ciências$gv. 89, n. 3, p. 1643-1653, 2017.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Agroindústria de Alimentos (CTAA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Expressão de busca inválida. Verifique!!! |
|
|
