Data/hora: 20/06/2024 02:24:05

Biblioteca(s): 	Embrapa Gado de Leite.	
Tipo da produção científica: 	Artigo em Periódico Indexado	
Circulação/Nível: 	A - 1	
Data corrente: 	26/11/2013	
Data da última atualização: 	05/02/2024	
Autoria: 	PENEDO, L. A.; NUNES, J. C.; GAMA, M. A. S. da; LEITE, P. E. C.; QUIRICO-SANTOS, T. F.; TORRES, A. G.	
Afiliação: 	LETÍCIA A. PENEDO, UFRJ, UFF; JULIANA C. NUNES, UFRJ; MARCO ANTONIO SUNDFELD DA GAMA, CNPGL; PAULO EMILIO C. LEITE, UFF; THEREZA F. QUIRICO-SANTOS, UFF; ALEXANDRE G. TORRES, UFRJ.	
Título: 	Intake of butter naturally enriched with cis9, trans11 conjugated linoleic acid reduces systemic inflammatory mediators in healthy young adults.	
Ano de publicação: 	2013	
Fonte/Imprenta: 	Journal of Nutritional Biochemistry, v. 24, p. 2144-2151, 2013.	
DOI: 	https://doi.org/10.1016/j.jnutbio.2013.08.006	
Idioma: 	Inglês	
Conteúdo: 	A conjugated linoleic acid (CLA) depletion-repletion study was carried out to investigate the effects of dietary c9,t11 CLA on C-reactive protein, transcription factor NFκB, metalloproteinases 2 and 9, inflammatory mediators (adiponectin, TNFα, IL-2, IL-4, IL-8, IL-10), body composition, and erythrocyte membrane composition in healthy normal-weight human adults. CLA depletion was achieved through an 8-week period of restricted dairy fat intake (depletion phase; CLA intake was 5.2±5.8 mg/day), followed by an 8-week period in which individuals consumed 20 g/day of butter naturally enriched with c9,t11 CLA (repletion phase; CLA intake of 1020±167 mg/day). The participants were 29 healthy adult volunteers (19 women and 10 men, aged 22 to 36 years), with body mass index between 18.0 and 29.9 kg m(-2). Blood samples were collected at baseline and at the end of both depletion and repletion phases. The content of CLA in erythrocytes decreased during CLA-depletion and increased during CLA-repletion. Intake of CLA-enriched butter increased the serum levels of anti-inflammatory IL-10 but reduced transcription factor NFκB in blood and serum levels of TNFα, IL-2, IL-8 and inactive metalloproteinase-9. Moreover, reduced activity of metalloproteinases 2 and 9 in serum was observed during the CLA-repletion period. In contrast, intake of CLA-enriched butter had no effects on body composition (DXA analysis) as well as on serum levels of adiponectin, C-reactive protein, and IL-4. Taken together, our results indicate that the intake of a c9,t11 CLA-enriched butter by normal-weight subjects induces beneficial changes in immune modulators associated with sub-clinical inflammation in overweight individuals.	
Palavras-Chave: 	Bioactive lipid; Depletion-repletion; Rumenic acid.	
Thesaurus Nal: 	cytokines; inflammation.	
Categoria do assunto: 	L Ciência Animal e Produtos de Origem Animal	
Registro original: 	Embrapa Gado de Leite (CNPGL)	
Exemplares: 	CNPGL - (20764-1) - UPC - AP - DD -  -  -  - DIS