| |
|
|
| Registros recuperados : 5 | |
| 1. |  | MORAIS, J. P. S.; THOMAZI, A. C.; MAMBRINI, G. P.; GIRALDI, T. R.; RIBEIRO, C. Análise da distribuição de tamanho de partículas de titânio metálico nanométrico. In: WORKSHOP DA REDE DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 5., 2009, São Carlos. Anais...São Carlos, SP: Embrapa Instrumentação Agropecuária, 2009. p. 171-172| Biblioteca(s): Embrapa Algodão. |
|   |
| 3. | | BERTINI, V. A.; FERREIRA, M. D.; MARCONCINI, J. M.; THOMAZI, A. C. Aplicação do wiltmeter na avaliação de embalagens de folhosas para conservação pós-colheita. In: JORNADA CIENTÍFICA - EMBRAPA SÃO CARLOS, 2., 2010, São Carlos, SP. Anais... São Carlos: Embrapa Instrumentação Agropecuária: Embrapa Pecuária Sudeste, 2010. p. 27. (Embrapa Instrumentação Agropecuária. Documentos, 50).| Biblioteca(s): Embrapa Instrumentação. |
|  |
| 5. | | MIRANDA, K. W. E.; NATARELLI, C. V. L.; THOMAZI, A. C.; FERREIRA, G. M. D.; FROTA, M. M.; BASTOS, M. do S. R.; MATTOSO, L. H. C.; OLIVEIRA, J. E. Halochromic polystyrene nanofibers obtained by solution blow spinning for wine pH sensing. Sensors, Switzerland, v. 20, n. 2, art. no. 417, 2020.| Biblioteca(s): Embrapa Agroindústria Tropical; Embrapa Instrumentação. |
| |
| Registros recuperados : 5 | |
|
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
Registro Completo
|
Biblioteca(s): |
Embrapa Instrumentação. |
|
Data corrente: |
08/11/2021 |
|
Data da última atualização: |
25/11/2022 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
MALAFATTI, J. O. D.; RUELLAS, T. M. de O.; MEIRELLES, M. R.; THOMAZI, A. C.; RENDA, C. G.; PARIS, E. C. |
|
Afiliação: |
ADRIANA COATRINI THOMAZI, CNPDIA; ELAINE CRISTINA PARIS, CNPDIA. |
|
Título: |
Nanocarriers of Eu3+ doped silica nanoparticles modified by APTES for luminescent monitoring of cloxacillin. |
|
Ano de publicação: |
2021 |
|
Fonte/Imprenta: |
AIMS Materials Science, v. 8, n. 5. |
|
Páginas: |
760?775 |
|
ISSN: |
2372-0484 |
|
DOI: |
10.3934/matersci.2021046 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Drug nanocarriers have been continuously improved to promote satisfactory release control. In this sense, luminescent materials have become an alternative option in clinical trials due to their ability to monitor drug delivery. Among the nanocarriers, silica stands out for structural stability, dispersibility, and surface reactivity. When using ceramic nanocarriers, one of the challenges is their interaction and selectivity capability for organic molecules, such as drugs. In order to overcome such adversity, superficial modifications can be carried out to enable a higher affinity for the desired drug. Thus, the present study aimed to obtain silica nanoparticles (NPs) doped with low concentrations of europium (III) superficially modified by (3-aminopropyl)triethoxysilane (APTES) to assess their interaction with the model drug cloxacillin benzathine. This drug was chosen because it is part of the ampicillin family and is commonly used in several treatments. Nearspherical and homogeneous silica NPs were obtained via sol-gel synthesis, with particle sizes of approximately 21 nm. It was possible to verify the fluorescence capacity of the silica NPs when doped with europium (III) in a mole percent that varied from 0.5 to 3.0%. A 10% volume percent of APTES caused the silica nanoparticles to increase the degree of hydrophobicity, with a shift in the contact angle from 8° to 51°. After surface modification by APTES, the silica nanocarrier (10 gꞏL−1) achieved a satisfactory degree of CLOX incorporation (25 gꞏL−1), increasing the adsorptive capacity to values above 50%. Therefore, silica NPs doped with europium (III) in a low percent of 0.5% (mole) modified by APTES showed promising results as an alternative option for trials and clinical studies of drug incorporation. MenosDrug nanocarriers have been continuously improved to promote satisfactory release control. In this sense, luminescent materials have become an alternative option in clinical trials due to their ability to monitor drug delivery. Among the nanocarriers, silica stands out for structural stability, dispersibility, and surface reactivity. When using ceramic nanocarriers, one of the challenges is their interaction and selectivity capability for organic molecules, such as drugs. In order to overcome such adversity, superficial modifications can be carried out to enable a higher affinity for the desired drug. Thus, the present study aimed to obtain silica nanoparticles (NPs) doped with low concentrations of europium (III) superficially modified by (3-aminopropyl)triethoxysilane (APTES) to assess their interaction with the model drug cloxacillin benzathine. This drug was chosen because it is part of the ampicillin family and is commonly used in several treatments. Nearspherical and homogeneous silica NPs were obtained via sol-gel synthesis, with particle sizes of approximately 21 nm. It was possible to verify the fluorescence capacity of the silica NPs when doped with europium (III) in a mole percent that varied from 0.5 to 3.0%. A 10% volume percent of APTES caused the silica nanoparticles to increase the degree of hydrophobicity, with a shift in the contact angle from 8° to 51°. After surface modification by APTES, the silica nanocarrier (10 gꞏL−1) achieved a satisfactory degree of... Mostrar Tudo |
|
Palavras-Chave: |
Luminescent materials; Surface modification. |
|
Categoria do assunto: |
-- |
|
Marc: |
LEADER 02525naa a2200241 a 4500
001 2135885
005 2022-11-25
008 2021 bl uuuu u00u1 u #d
022 $a2372-0484
024 7 $a10.3934/matersci.2021046$2DOI
100 1 $aMALAFATTI, J. O. D.
245 $aNanocarriers of Eu3+ doped silica nanoparticles modified by APTES for luminescent monitoring of cloxacillin.$h[electronic resource]
260 $c2021
300 $a760?775
520 $aDrug nanocarriers have been continuously improved to promote satisfactory release control. In this sense, luminescent materials have become an alternative option in clinical trials due to their ability to monitor drug delivery. Among the nanocarriers, silica stands out for structural stability, dispersibility, and surface reactivity. When using ceramic nanocarriers, one of the challenges is their interaction and selectivity capability for organic molecules, such as drugs. In order to overcome such adversity, superficial modifications can be carried out to enable a higher affinity for the desired drug. Thus, the present study aimed to obtain silica nanoparticles (NPs) doped with low concentrations of europium (III) superficially modified by (3-aminopropyl)triethoxysilane (APTES) to assess their interaction with the model drug cloxacillin benzathine. This drug was chosen because it is part of the ampicillin family and is commonly used in several treatments. Nearspherical and homogeneous silica NPs were obtained via sol-gel synthesis, with particle sizes of approximately 21 nm. It was possible to verify the fluorescence capacity of the silica NPs when doped with europium (III) in a mole percent that varied from 0.5 to 3.0%. A 10% volume percent of APTES caused the silica nanoparticles to increase the degree of hydrophobicity, with a shift in the contact angle from 8° to 51°. After surface modification by APTES, the silica nanocarrier (10 gꞏL−1) achieved a satisfactory degree of CLOX incorporation (25 gꞏL−1), increasing the adsorptive capacity to values above 50%. Therefore, silica NPs doped with europium (III) in a low percent of 0.5% (mole) modified by APTES showed promising results as an alternative option for trials and clinical studies of drug incorporation.
653 $aLuminescent materials
653 $aSurface modification
700 1 $aRUELLAS, T. M. de O.
700 1 $aMEIRELLES, M. R.
700 1 $aTHOMAZI, A. C.
700 1 $aRENDA, C. G.
700 1 $aPARIS, E. C.
773 $tAIMS Materials Science$gv. 8, n. 5.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Instrumentação (CNPDIA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
