Data/hora: 21/09/2024 20:51:22

Biblioteca(s): 	Embrapa Gado de Leite.	
Data corrente: 	19/11/2013	
Data da última atualização: 	05/02/2024	
Autoria: 	UTSUNOMIYA, Y. T.; CARMO, A. S. do; CARVALHEIRO, R.; NEVES, H. H. R.; MATOS, M. C.; ZAVAREZ, L. B.; O'BRIEN, A. M. P.; SÖLKNER, J.; McEWAN, J. C.; COLE, J. B.; TASSEL, C. P. V.; SCHENKEL, F. S.; SILVA, M. V. G. B.; PORTO NETO, L. R.; SONSTEGARD, T. S.; GARCIA, J. F.	
Afiliação: 	YURI T. UTSUNOMIYA, UNESP; ADRIANA S. DO CARMO, UNESP; ROBERTO CARVALHEIRO, GenSys Consultores Associados; HAROLDO H. R. NEVES, UNESP; MÁRCIA C. MATOS, UNESP; LUDMILLA B. ZAVAREZ, UNESP; ANA M. PÉREZ O'BRIEN, University of Natural Resources and Life Sciences, Vienna; JOHANN SÖLKNER, University of Natural Resources and Life Sciences, Vienna; JOHN C. McEWAN, Centre for Reproduction and Genomics, AgResearch, Mosgiel, New Zealand; JOHN B. COLE, ARS-USDA, USA; CURTIS P. VAN TASSEL, ARS-USDA, USA; FLÁVIO S. SCHENKEL, University of Guelph, Canada; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; LAERCIO R. PORTO NETO, University of Queensland, Australia; University of New England, Australia; TAD S. SONSTEGARD, ARS-USDA, USA; JOSÉ F. GARCIA, UNESP.	
Título: 	Genome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height.	
Ano de publicação: 	2013	
Fonte/Imprenta: 	BMC Genetics, London, v. 14, article 52, 2013.	
DOI: 	https://doi.org/10.1186/1471-2156-14-52	
Idioma: 	Inglês	
Conteúdo: 	Background - Birth weight (BW) is an economically important trait in beef cattle, and is associated with growth- and stature-related traits and calving difficulty. One region of the cattle genome, located on Bos primigenius taurus chromosome 14 (BTA14), has been previously shown to be associated with stature by multiple independent studies, and contains orthologous genes affecting human height. A genome-wide association study (GWAS) for BW in Brazilian Nellore cattle (Bos primigenius indicus) was performed using estimated breeding values (EBVs) of 654 progeny-tested bulls genotyped for over 777,000 single nucleotide polymorphisms (SNPs). Results - The most significant SNP (rs133012258, PGC = 1.34 × 10-9), located at BTA14:25376827, explained 4.62% of the variance in BW EBVs. The surrounding 1 Mb region presented high identity with human, pig and mouse autosomes 8, 4 and 4, respectively, and contains the orthologous height genes PLAG1, CHCHD7, MOS, RPS20, LYN, RDHE2 (SDR16C5) and PENK. The region also overlapped 28 quantitative trait loci (QTLs) previously reported in literature by linkage mapping studies in cattle, including QTLs for birth weight, mature height, carcass weight, stature, pre-weaning average daily gain, calving ease, and gestation length. Conclusions- This study presents the first GWAS applying a high-density SNP panel to identify putative chromosome regions affecting birth weight in Nellore cattle. These results suggest that the QTLs on BTA14 associated with body size in taurine cattle (Bos primigenius taurus) also affect birth weight and size in zebu cattle (Bos primigenius indicus).	
Palavras-Chave: 	Bos primigenius indicus; GWAS; Nellore cattle; Stature.	
Thesaurus Nal: 	birth weight.	
Categoria do assunto: 	G Melhoramento Genético	
Registro original: 	Embrapa Gado de Leite (CNPGL)	
Exemplares: 	CNPGL - (20756-1) - UPC - AP - DD -  -  -  - DIS