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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
11/12/2023 |
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Autoria: |
COLDITZ, I. G.; WATSON, D. L. |
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Título: |
The role of humoral and cellular mediators in enhanced mammary inflammatory reactions to staphylococcal infection in systemically immunized ewes. |
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Ano de publicação: |
1982 |
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Fonte/Imprenta: |
Microbiology and Immnology, v. 26, n. 12, p. 1171-1180, 1982. |
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DOI: |
10.1111/j.1348-0421.1982.tb00266.x. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Prior systemic immunization with live Staphylococcus aureus vaccine enhances the early recruitment of neutrophils into nonlactating mammary glands infected with staphylococci. The study investigates the role of humoral and cellular mediators in this phenomenon. Intramammary infusion of bacteria suspended in immune sheep serum did not enhance the inflammatory response to infection in nonimmunized ewes despite the presence of complement in the infused serum. Infusion of complement activated by incubation with zymosan evoked a massive neutrophil influx into mammary secretions by 4 hr after infusion. Hemolytic complement activity was not detected in mammary secretions of immunized or nonimmunized ewes. These findings indicate that, despite the inflammatory effect of complement activation, humoral immune factors did not promote neutrophil migration into infected glands. Mammary glands of systemically immunized ewes stimulated 5 days previously with staphylococcal soluble antigens (SSA) supported larger neutrophil influxes during staphylococcal infection than contralateral glands stimulated with endotoxin 5 days prior to infection. Exudates of SSA-stimulated glands had significantly higher cell concentrations, prior to infection, than endotoxin-stimulated glands; however elevated cell concentrations in endotoxin-stimulated glands of nonimmune ewes did not support enhanced inflammatory responses. These findings suggest that qualitative but not quantitative characteristics of mammary leucocytes influence the inflammatory response to infection in systemically immunized ewes. MenosAbstract: Prior systemic immunization with live Staphylococcus aureus vaccine enhances the early recruitment of neutrophils into nonlactating mammary glands infected with staphylococci. The study investigates the role of humoral and cellular mediators in this phenomenon. Intramammary infusion of bacteria suspended in immune sheep serum did not enhance the inflammatory response to infection in nonimmunized ewes despite the presence of complement in the infused serum. Infusion of complement activated by incubation with zymosan evoked a massive neutrophil influx into mammary secretions by 4 hr after infusion. Hemolytic complement activity was not detected in mammary secretions of immunized or nonimmunized ewes. These findings indicate that, despite the inflammatory effect of complement activation, humoral immune factors did not promote neutrophil migration into infected glands. Mammary glands of systemically immunized ewes stimulated 5 days previously with staphylococcal soluble antigens (SSA) supported larger neutrophil influxes during staphylococcal infection than contralateral glands stimulated with endotoxin 5 days prior to infection. Exudates of SSA-stimulated glands had significantly higher cell concentrations, prior to infection, than endotoxin-stimulated glands; however elevated cell concentrations in endotoxin-stimulated glands of nonimmune ewes did not support enhanced inflammatory responses. These findings suggest that qualitative but not quantitative characteristics... Mostrar Tudo |
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Palavras-Chave: |
Administration dosage; Complement system proteins; Complications; Estafilococus; Infecao; Mastite; Staphylococcal infections; Staphylococcal Vaccines. |
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Thesagro: |
Doença; Microbiologia; Ovino. |
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Thesaurus Nal: |
Antibody formation; Etiology; Immunology; Mammary gland diseases; Mastitis; Neutrophils; Pregnancy; Sheep diseases; Somatic cell count. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 02761naa a2200385 a 4500
001 1519523
005 2023-12-11
008 1982 bl uuuu u00u1 u #d
024 7 $a10.1111/j.1348-0421.1982.tb00266.x.$2DOI
100 1 $aCOLDITZ, I. G.
245 $aThe role of humoral and cellular mediators in enhanced mammary inflammatory reactions to staphylococcal infection in systemically immunized ewes.$h[electronic resource]
260 $c1982
520 $aAbstract: Prior systemic immunization with live Staphylococcus aureus vaccine enhances the early recruitment of neutrophils into nonlactating mammary glands infected with staphylococci. The study investigates the role of humoral and cellular mediators in this phenomenon. Intramammary infusion of bacteria suspended in immune sheep serum did not enhance the inflammatory response to infection in nonimmunized ewes despite the presence of complement in the infused serum. Infusion of complement activated by incubation with zymosan evoked a massive neutrophil influx into mammary secretions by 4 hr after infusion. Hemolytic complement activity was not detected in mammary secretions of immunized or nonimmunized ewes. These findings indicate that, despite the inflammatory effect of complement activation, humoral immune factors did not promote neutrophil migration into infected glands. Mammary glands of systemically immunized ewes stimulated 5 days previously with staphylococcal soluble antigens (SSA) supported larger neutrophil influxes during staphylococcal infection than contralateral glands stimulated with endotoxin 5 days prior to infection. Exudates of SSA-stimulated glands had significantly higher cell concentrations, prior to infection, than endotoxin-stimulated glands; however elevated cell concentrations in endotoxin-stimulated glands of nonimmune ewes did not support enhanced inflammatory responses. These findings suggest that qualitative but not quantitative characteristics of mammary leucocytes influence the inflammatory response to infection in systemically immunized ewes.
650 $aAntibody formation
650 $aEtiology
650 $aImmunology
650 $aMammary gland diseases
650 $aMastitis
650 $aNeutrophils
650 $aPregnancy
650 $aSheep diseases
650 $aSomatic cell count
650 $aDoença
650 $aMicrobiologia
650 $aOvino
653 $aAdministration dosage
653 $aComplement system proteins
653 $aComplications
653 $aEstafilococus
653 $aInfecao
653 $aMastite
653 $aStaphylococcal infections
653 $aStaphylococcal Vaccines
700 1 $aWATSON, D. L.
773 $tMicrobiology and Immnology$gv. 26, n. 12, p. 1171-1180, 1982.
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| 12. |  | SOUZA, R. O. de L.; SILVA, D. S.; LEAL, T. M. A influência da suplementação alimentar e da frequência de amamentação sobre a atividade ovariana pós-parto em ovelhas da raça Santa Inês e sobre o desempenho ponderal dos cordeiros. In: SIMPÓSIO DE PRODUÇÃO CIENTÍFICA, 6.; SEMINÁRIO DE INICIAÇÃO CIENTÍFICA, 4.; SEMINÁRIO DE PÓS-GRADUAÇÃO, 3., 2005, Teresina, PI. Resumos... Teresina: UESPI, 2005. p. 207| Tipo: Resumo em Anais de Congresso |
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