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Registro Completo |
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
19/10/2018 |
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Data da última atualização: |
19/10/2018 |
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Autoria: |
OLIVEIRA, A. P. L.; RANGEL, J. P. P.; RIODADES, L. F. S.; ALMEIDA, B. L.; MATHIAS, C. H. T.; CONTI, L. M. C.; FIORIO, W. A. B.; MONTEIRO, B. S. |
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Afiliação: |
Alvaro P. L. Oliveira, Mestrado em Zootecnia, Laboratório de Células-tronco e Terapia Celular/Departamento de Medicina Veterinária/Universidade Vila Velha - UVV; Julia P. P. Rangel, Mestrado em Zootecnia, Laboratório de Células-tronco e Terapia Celular/Departamento de Medicina Veterinária/Universidade Vila Velha - UVV; Luiz F. S. Riodades, Graduação em Medicina Veterinária, Bolsa de Iniciação Científica/Departamento de Medicina Veterinária/Universidade Vila Velha - UVV; Bruna L. Almeida, Graduação em Medicina Veterinária, Bolsa de Iniciação Científica/Departamento de Medicina Veterinária/Universidade Vila Velha - UVV; Carlos Henrique T. Mathias, Mestrado em Zootecnia, Laboratório de Células-tronco e Terapia Celular/Departamento de Medicina Veterinária/Universidade Vila Velha - UVV; Laura M. C. Conti, Mestrado em Zootecnia, Laboratório de Células-tronco e Terapia Celular/Departamento de Medicina Veterinária/Universidade Vila Velha - UVV; Wagner A. B. Fiorio, Mestrado em Zootecnia/Laboratório de Células-tronco e Terapia Celular/Departamento de Medicina Veterinária/ Universidade Vila Velha - UVV; Betânia S. Monteiro, Professor de Pós-Graduação em Zootecnia/Laboratório de Células-tronco e Terapia Celular/Departamento de Medicina Veterinária/Universidade Vila Velha - UVV. |
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Título: |
Establishment of an experimental model of small intestinal ischemia and reperfusion injuries in New Zealand rabbits. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Brasília, DF, v. 38, n 8, p. 1664-1674, agosto 2018 |
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Idioma: |
Inglês |
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Notas: |
Título em português: Estabelecimento de modelo experimental de indução da lesão de isquemia e reperfusão de intestino delgado em coelhos Nova Zelândia. |
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Conteúdo: |
The present study aimed to establish a methodology capable to cause intestinal ischemia and reperfusion injuries, to perform clamping of the jejunal segment of the extramural peri-intestinal marginal artery branch. For this, 37, 10-week-old male New Zealand breed rabbits were used. One rabbit was used to establish the anatomic references for the procedure and was not part of the six experimental groups; the rest were allocated into six experimental groups: Sham group, negative control, subjected only to midline celiotomy; group I1H undergoing vascular occlusion for an hour; group I2H submitted to vascular occlusion for two hours; group I1H/R2H undergoing vascular occlusion for one hour followed by two hours of reperfusion; group I2H/R1H undergoing vascular occlusion for two hours, followed by reperfusion for one hour, and group I2H/R5H undergoing vascular occlusion for two hours followed by reperfusion for five hours. The rabbits were evaluated for the macroscopic aspects (color and peristalsis) of the jejunal segment, as well as the histological aspect, checking for presence or absence of mucosal destruction, edema, hemorrhaging, lymphatic vessel dilatation, and the presence of polymorphonuclear cells. It was observed that the macroscopic and histopathological lesions accentuated in larger employed ischemia and reperfusion times. Rabbits subjected to ischemia for two hours followed by reperfusion for five hours (I2H/R5H) made up the experimental group which was easily reproducible and showed moderate intestinal injury, different from the other groups. MenosThe present study aimed to establish a methodology capable to cause intestinal ischemia and reperfusion injuries, to perform clamping of the jejunal segment of the extramural peri-intestinal marginal artery branch. For this, 37, 10-week-old male New Zealand breed rabbits were used. One rabbit was used to establish the anatomic references for the procedure and was not part of the six experimental groups; the rest were allocated into six experimental groups: Sham group, negative control, subjected only to midline celiotomy; group I1H undergoing vascular occlusion for an hour; group I2H submitted to vascular occlusion for two hours; group I1H/R2H undergoing vascular occlusion for one hour followed by two hours of reperfusion; group I2H/R1H undergoing vascular occlusion for two hours, followed by reperfusion for one hour, and group I2H/R5H undergoing vascular occlusion for two hours followed by reperfusion for five hours. The rabbits were evaluated for the macroscopic aspects (color and peristalsis) of the jejunal segment, as well as the histological aspect, checking for presence or absence of mucosal destruction, edema, hemorrhaging, lymphatic vessel dilatation, and the presence of polymorphonuclear cells. It was observed that the macroscopic and histopathological lesions accentuated in larger employed ischemia and reperfusion times. Rabbits subjected to ischemia for two hours followed by reperfusion for five hours (I2H/R5H) made up the experimental group which was easily repro... Mostrar Tudo |
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Thesaurus Nal: |
Animal injuries; Heterophils; Intestinal mucosa; New Zealand; Rabbits. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/184769/1/Establishment-of-an-experimental-model-of-small.pdf
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Marc: |
LEADER 02583naa a2200277 a 4500
001 2097806
005 2018-10-19
008 2018 bl uuuu u00u1 u #d
100 1 $aOLIVEIRA, A. P. L.
245 $aEstablishment of an experimental model of small intestinal ischemia and reperfusion injuries in New Zealand rabbits.$h[electronic resource]
260 $c2018
500 $aTítulo em português: Estabelecimento de modelo experimental de indução da lesão de isquemia e reperfusão de intestino delgado em coelhos Nova Zelândia.
520 $aThe present study aimed to establish a methodology capable to cause intestinal ischemia and reperfusion injuries, to perform clamping of the jejunal segment of the extramural peri-intestinal marginal artery branch. For this, 37, 10-week-old male New Zealand breed rabbits were used. One rabbit was used to establish the anatomic references for the procedure and was not part of the six experimental groups; the rest were allocated into six experimental groups: Sham group, negative control, subjected only to midline celiotomy; group I1H undergoing vascular occlusion for an hour; group I2H submitted to vascular occlusion for two hours; group I1H/R2H undergoing vascular occlusion for one hour followed by two hours of reperfusion; group I2H/R1H undergoing vascular occlusion for two hours, followed by reperfusion for one hour, and group I2H/R5H undergoing vascular occlusion for two hours followed by reperfusion for five hours. The rabbits were evaluated for the macroscopic aspects (color and peristalsis) of the jejunal segment, as well as the histological aspect, checking for presence or absence of mucosal destruction, edema, hemorrhaging, lymphatic vessel dilatation, and the presence of polymorphonuclear cells. It was observed that the macroscopic and histopathological lesions accentuated in larger employed ischemia and reperfusion times. Rabbits subjected to ischemia for two hours followed by reperfusion for five hours (I2H/R5H) made up the experimental group which was easily reproducible and showed moderate intestinal injury, different from the other groups.
650 $aAnimal injuries
650 $aHeterophils
650 $aIntestinal mucosa
650 $aNew Zealand
650 $aRabbits
700 1 $aRANGEL, J. P. P.
700 1 $aRIODADES, L. F. S.
700 1 $aALMEIDA, B. L.
700 1 $aMATHIAS, C. H. T.
700 1 $aCONTI, L. M. C.
700 1 $aFIORIO, W. A. B.
700 1 $aMONTEIRO, B. S.
773 $tPesquisa Veterinária Brasileira, Brasília, DF$gv. 38, n 8, p. 1664-1674, agosto 2018
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