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| Registros recuperados : 214 | |
| 82. |  | EHRHARDT, M. V. S; ESASHIKA, D. A. S.; MICHEREFF FILHO, M.; SILVA, P. S; ESCOPELLI, H. F. Associação de controle químico e da resistência varietal para redução da trnasmissão de begomovírus ao tomateiro. In: JORNADA CIENTÍFICA DA EMBRAPA HORTALIÇAS, 4., 2014, Brasília, DF. Resumos... Brasília: Embrapa Hortaliças, 2014. Resumo 2.| Biblioteca(s): Embrapa Hortaliças. |
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| 83. | | SILVA, P. S.; FERRARA, F. A. A.; AGUIAR-MENEZES, E. de L.; BONIFÁCIO, G. S.; SILVA, A. C. da. Associação entre plantas frutíferas hospedeiras e espécies de moscas-das-frutas no município de Bom Jesus do Itabapoana. In: CONGRESSO BRASILEIRO DE FRUTICULTURA, 20., ANNUAL MEETING OF THE AMERICAN SOCIETY FOR THE TROPICAL HORTICULTURAE, 54., 12 A 17 de outubro de 2008, Vitória, ES. Anais... Vitória, ES, 2008 Parceria: UFF, UFRRJ.| Biblioteca(s): Embrapa Agrobiologia. |
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| 84. | | KLUMB, E. K.; SILVA, P. S.; MELLO, D. C.; LAVANDOSKI, A. P.; SILVEIRA, A. D.; SCIVITTARO, W. B. Absorção de fósforo e potássio pelo arroz irrigado por inundação do solo e aspersão. In: ENCONTRO DE INICIAÇÃO CIENTÍFICA E PÓS-GRADUAÇÃO DA EMBRAPA CLIMA TEMPERADO, 4., 2012, Pelotas. Ciência e inovação para 2050: qual o futuro que queremos? Resumos e palestras... Pelotas: Embrapa Clima Temperado, 2012. 1 CD-ROM.| Biblioteca(s): Embrapa Clima Temperado. |
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| 85. | | OLIVEIRA, L. G. G.; SILVA, P. S.; SOLARI, F. L.; TRENTIN, G.; SILVEIRA, M. C. T. da. Avaliação de características estruturais de festuca, sob manejo rotacionário ao longo de ciclos de pastejo. In: CONGRESSO DE INICIAÇÃO CIENTÍFICA, 26.; ENCONTRO DE PÓS-GRADUAÇÃO UFPEL, 19.; SEMANA INTEGRADA DE ENSINO, PESQUISA E EXTENSÃO, 3., 2017, Pelotas. Anais... Pelotas: UFPel, 2017.| Biblioteca(s): Embrapa Pecuária Sul. |
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| 86. | | KIRINUS, M. B. M.; SILVA, P. S.; BARRETO, C. F.; OLIVEIRA, R. P. de; MALGARIM, M. B. Diagnose foliar em tangerina 'Satsuma Okitsu' submetida à aplicação de selênio. Agrarian, Dourados, v. 15, n. 55, e15215, 2022.| Biblioteca(s): Embrapa Clima Temperado. |
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| 87. | | SILVA, P. S. L.; SILVA, P. I. B.; OLIVEIRA, V. R.; SILVA, K. E. F.; MONTEIRO, A. L. Doses of carnauba leaf residues and corn yield. Horticultura Brasileira, Brasília, DF, v. 32, n. 1, p. 74-80, jan./mar. 2014.| Biblioteca(s): Embrapa Hortaliças. |
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| 92. | | SILVA, P. S. da; OLIVEIRA, L. G. G. de; SILVEIRA, M. C. T. da; GENRO, T. C. M. Caracterização da massa de forragem do pastejo simulado de capim-sudão BRS Estribo com e sem irrigação. In: SIMPÓSIO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA PECUÁRIA SUL, 8., 2018, Bagé. Resumos... Bagé: Embrapa Pecuária Sul, 2018. p. 21. (Embrapa Pecuária Sul. Eventos técnicos & científicos, 1). Fernando Flores Cardoso, Daniel Portella Montardo, José Carlos Ferrugem Moraes, Marcos Flávio Silva Borba, Sandro da Silva Camargo, editores técnicos.| Biblioteca(s): Embrapa Pecuária Sul. |
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| 93. | | SILVA FILHO, A. J. R. da; ANTONIO, R. P.; SILVA, P. S. L.; SILVEIRA, L. M. da; ALBUQURQUE, L. B. Avaliação morfológica e agronômica de sementes de acessos de caupi coletados no Rio Grande do Norte. Agropecuária Científica no Semi-Árido, Patos, v. 9, n. 4, p. 102-106, out./dez. 2013.| Biblioteca(s): Embrapa Semiárido. |
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| 95. | | SCIVITTARO, W. B.; SILVA, R. S. da; MARCO, E. de; KLUMB, E. K.; SILVA, P. S. da. Tolerância de genótipos de arroz à salinidade da água de irrigação na fase vegetativa. In: REUNIÃO BRASILEIRA DE FERTILIDADE DO SOLO E NUTRIÇÃO DE PLANTAS, 30.; REUNIÃO BRASILEIRA SOBRE MICORRIZAS, 14.; SIMPÓSIO BRASILEIRO DE MICROBIOLOGIA DO SOLO, 12.; REUNIÃO BRASILEIRA DE BIOLOGIA DO SOLO, 9., SIMPÓSIO SOBRE SELÊNIO NO BRASIL. Maceio. A responsabilidade socioambiental da pesquisa agrícola: resumos, Vicoça: SBCS, 2012. p. 1-4| Biblioteca(s): Embrapa Clima Temperado. |
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| 96. | | MOURA, A. P. de; CARVALHO, G. A.; COSME, L. V.; ALVES, E.; BOTTON, M.; SILVA, P. S. Toxicological and ultrastructural analysis of the impact of pesticides used in temperate fruit cropson two populations of Chrysoperla externa (Neuroptera, Chrysopidae). Revista Brasileira de Entomologia, São Paulo, v. 55, n. 3, p. 411-418 set. 2011.| Biblioteca(s): Embrapa Hortaliças; Embrapa Uva e Vinho. |
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| 97. | | OLIVEIRA, L. G. G. de; SILVA, P. S. da; SILVEIRA, M. C. T. da; LAMEGO, F. P. Comparação de dois estudos de fluxo e renovação de folhas em diferentes gerações de perfilho de capim-annoni-2. In: SIMPÓSIO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA PECUÁRIA SUL, 9., 2019, Bagé. Resumos... Bagé: Embrapa Pecuária Sul, 2019. p. 22. (Embrapa Pecuária Sul. Eventos técnicos & científicos, 2). Fernando Flores Cardoso, editor técnico.| Biblioteca(s): Embrapa Pecuária Sul. |
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| 99. | | BARRETO, C. F.; MORENO, M. B.; SILVA, P. S. da; FARIAS, R. de M.; FACHINELLO, J. C.; MARTINS, C. R. Conservação de maçãs 'fuji suprema'minimamente processados Revista Iberoamericana de Tecnología Postcosecha, v. 17, n. 1, p. 99-105, 2016.| Biblioteca(s): Embrapa Clima Temperado. |
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| Registros recuperados : 214 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
16/03/2011 |
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Data da última atualização: |
22/03/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
COSTA, D. C. S.; BELO, V. A.; SILVA, P. S.; METZGER, I. F.; LANNA, C. M.; MACHADO, M. A.; SANTOS, J. E. T. |
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Afiliação: |
D. C. SOUZA COSTA, UFJF; V. A. BELO, UNICAMP; P. S. SILVA, UNICAMP; I. F. METZGER, FMRP/USP; C. M. LANNA, UFJF; MARCO ANTONIO MACHADO, CNPGL; J. E. TANUS SANTOS, FMRP/USP. |
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Título: |
eNOS haplotype associated with hypertension in obese children and adolescents. |
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Ano de publicação: |
2010 |
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Fonte/Imprenta: |
International Journal of Obesity, v. 35, p. 387-392, 2010. |
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DOI: |
https://doi.org/10.1038/ijo.2010.146 |
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Idioma: |
Inglês |
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Conteúdo: |
The aim of our study is to investigate whether genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (in the promoter region T−786C, in exon 7 (Glu298Asp) and in intron 4 (4b/4a)) or eNOS haplotypes are associated with hypertension in obese children and adolescents. Methods: We genotyped 175 healthy (controls), 110 normotensive obese and 73 hypertensive obese children and adolescents. Genotypes were determined by Taqman allele discrimination assay and real-time PCR, and by PCR followed by fragment separation by electrophoresis. We compared the distribution of eNOS genotypes, alleles and haplotypes in the three study groups of subjects. We have also measured whole-blood nitrite concentrations. Results: The 4a4a genotype for the intron 4 polymorphism was more common in normotensive obese and hypertensive obese (P<0.01). The AspAsp genotype for Glu298Asp polymorphism was less common in normotensive obese (P<0.02). No significant differences were found in allele distributions for the three eNOS polymorphisms. However, the haplotype combining the C, 4b and Glu variants for the three polymorphisms was more common in hypertensive obese than in normotensive obese or control children and adolescents (odds ratio=2.28 and 2.79, respectively; 95% confidence interval: 1.31–4.31 and 1.39–5.64, respectively; both P<0.00625). This haplotype was not associated with significantly different nitrite concentrations (P>0.05). Conclusions:Our findings suggest that the eNOS haplotype, C b Glu, is associated with hypertension in obese children and adolescents. Further studies examining the possible interactions of eNOS haplotypes with environmental factors and other genetic markers involved in the development of obesity and its complications are warranted. MenosThe aim of our study is to investigate whether genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (in the promoter region T−786C, in exon 7 (Glu298Asp) and in intron 4 (4b/4a)) or eNOS haplotypes are associated with hypertension in obese children and adolescents. Methods: We genotyped 175 healthy (controls), 110 normotensive obese and 73 hypertensive obese children and adolescents. Genotypes were determined by Taqman allele discrimination assay and real-time PCR, and by PCR followed by fragment separation by electrophoresis. We compared the distribution of eNOS genotypes, alleles and haplotypes in the three study groups of subjects. We have also measured whole-blood nitrite concentrations. Results: The 4a4a genotype for the intron 4 polymorphism was more common in normotensive obese and hypertensive obese (P<0.01). The AspAsp genotype for Glu298Asp polymorphism was less common in normotensive obese (P<0.02). No significant differences were found in allele distributions for the three eNOS polymorphisms. However, the haplotype combining the C, 4b and Glu variants for the three polymorphisms was more common in hypertensive obese than in normotensive obese or control children and adolescents (odds ratio=2.28 and 2.79, respectively; 95% confidence interval: 1.31–4.31 and 1.39–5.64, respectively; both P<0.00625). This haplotype was not associated with significantly different nitrite concentrations (P>0.05). Conclusions:Our findings suggest that the eNOS hap... Mostrar Tudo |
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Palavras-Chave: |
ENOS. |
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Thesaurus NAL: |
children; haplotypes; hypertension; nitric oxide. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/881116/1/eNOS-haplotype-associated-with-hypertension.pdf
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Marc: |
LEADER 02551naa a2200265 a 4500
001 1881116
005 2024-03-22
008 2010 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1038/ijo.2010.146$2DOI
100 1 $aCOSTA, D. C. S.
245 $aeNOS haplotype associated with hypertension in obese children and adolescents.$h[electronic resource]
260 $c2010
520 $aThe aim of our study is to investigate whether genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (in the promoter region T−786C, in exon 7 (Glu298Asp) and in intron 4 (4b/4a)) or eNOS haplotypes are associated with hypertension in obese children and adolescents. Methods: We genotyped 175 healthy (controls), 110 normotensive obese and 73 hypertensive obese children and adolescents. Genotypes were determined by Taqman allele discrimination assay and real-time PCR, and by PCR followed by fragment separation by electrophoresis. We compared the distribution of eNOS genotypes, alleles and haplotypes in the three study groups of subjects. We have also measured whole-blood nitrite concentrations. Results: The 4a4a genotype for the intron 4 polymorphism was more common in normotensive obese and hypertensive obese (P<0.01). The AspAsp genotype for Glu298Asp polymorphism was less common in normotensive obese (P<0.02). No significant differences were found in allele distributions for the three eNOS polymorphisms. However, the haplotype combining the C, 4b and Glu variants for the three polymorphisms was more common in hypertensive obese than in normotensive obese or control children and adolescents (odds ratio=2.28 and 2.79, respectively; 95% confidence interval: 1.31–4.31 and 1.39–5.64, respectively; both P<0.00625). This haplotype was not associated with significantly different nitrite concentrations (P>0.05). Conclusions:Our findings suggest that the eNOS haplotype, C b Glu, is associated with hypertension in obese children and adolescents. Further studies examining the possible interactions of eNOS haplotypes with environmental factors and other genetic markers involved in the development of obesity and its complications are warranted.
650 $achildren
650 $ahaplotypes
650 $ahypertension
650 $anitric oxide
653 $aENOS
700 1 $aBELO, V. A.
700 1 $aSILVA, P. S.
700 1 $aMETZGER, I. F.
700 1 $aLANNA, C. M.
700 1 $aMACHADO, M. A.
700 1 $aSANTOS, J. E. T.
773 $tInternational Journal of Obesity$gv. 35, p. 387-392, 2010.
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