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Registro Completo |
Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
Data corrente: |
24/07/2019 |
Data da última atualização: |
09/01/2020 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
OLIVEIRA, P. S. N. de; COUTINHO, L. L.; CESAR, A. S. M.; DINIZ, W. J. da S.; SOUZA, M. de S.; ANDRADE, B. G.; KOLTES, J. E.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; REGITANO, L. C. de A. |
Afiliação: |
PRISCILA S. N. DE OLIVEIRA, CPPSE; LUIZ L. COUTINHO, Esalq/USP; ALINE S. M. CESAR, Esalq/USP; WELLISON J. DA SILVA DINIZ, UFSCar; MARCELA M. DE SOUZA, Iowa State University; BRUNO G. ANDRADE, CPPSE; JAMES E. KOLTES, Iowa State University; GERSON B. MOURÃO, Esalq/USP; ADHEMAR ZERLOTINI NETO, CNPTIA; JAMES M. REECY, Iowa State University; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
Título: |
Co-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle. |
Ano de publicação: |
2019 |
Fonte/Imprenta: |
Frontiers in Genetics, v. 10, p. 1-14, July 2019. |
DOI: |
10.3389/fgene.2019.00651 |
Idioma: |
Inglês |
Notas: |
Article 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano. |
Conteúdo: |
Fatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate pathways of phenotype modulation that could positively benefit beef production and human consumption. MenosFatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate... Mostrar Tudo |
Palavras-Chave: |
Ácido linoleico conjugado; Ácido oleico; Ácidos graxos; Genômica; Integrative genomics; MiRNA; MRNA; Redes de co-expressão. |
Thesagro: |
Bos Indicus; Gado de Corte. |
Thesaurus Nal: |
Beef cattle; Conjugated linoleic acid; Oleic acid. |
Categoria do assunto: |
-- L Ciência Animal e Produtos de Origem Animal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/199817/1/AP-Coexpression-networks.pdf
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Marc: |
LEADER 02877naa a2200421 a 4500 001 2110872 005 2020-01-09 008 2019 bl uuuu u00u1 u #d 024 7 $a10.3389/fgene.2019.00651$2DOI 100 1 $aOLIVEIRA, P. S. N. de 245 $aCo-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle.$h[electronic resource] 260 $c2019 500 $aArticle 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano. 520 $aFatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate pathways of phenotype modulation that could positively benefit beef production and human consumption. 650 $aBeef cattle 650 $aConjugated linoleic acid 650 $aOleic acid 650 $aBos Indicus 650 $aGado de Corte 653 $aÁcido linoleico conjugado 653 $aÁcido oleico 653 $aÁcidos graxos 653 $aGenômica 653 $aIntegrative genomics 653 $aMiRNA 653 $aMRNA 653 $aRedes de co-expressão 700 1 $aCOUTINHO, L. L. 700 1 $aCESAR, A. S. M. 700 1 $aDINIZ, W. J. da S. 700 1 $aSOUZA, M. de S. 700 1 $aANDRADE, B. G. 700 1 $aKOLTES, J. E. 700 1 $aMOURÃO, G. B. 700 1 $aZERLOTINI NETO, A. 700 1 $aREECY, J. M. 700 1 $aREGITANO, L. C. de A. 773 $tFrontiers in Genetics$gv. 10, p. 1-14, July 2019.
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Embrapa Pecuária Sudeste (CPPSE) |
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![](/consulta/web/img/deny.png) | Acesso ao texto completo restrito à biblioteca da Embrapa Florestas. Para informações adicionais entre em contato com cnpf.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Florestas. |
Data corrente: |
18/02/2019 |
Data da última atualização: |
30/10/2019 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
MATTOS, B. D.; SILVA, L. R. da; SOUZA, I. R. de; MAGALHAES, W. L. E.; LEME, D. M. |
Afiliação: |
Bruno Dufau Mattos, Aalto University; Lucas Rafael da Silva, UFPR; Irisdoris Rodrigues de Souza, UFPR; WASHINGTON LUIZ ESTEVES MAGALHAES, CNPF; Daniela Morais Leme, UFPR. |
Título: |
Slow delivery of biocide from nanostructured, microscaled, particles reduces its phytoxicity: a model investigation. |
Ano de publicação: |
2019 |
Fonte/Imprenta: |
Journal of Hazardous Materials, v. 367, p. 513-519, Apr. 2019. 7 p. |
DOI: |
10.1016/j.jhazmat.2018.12.117 |
Idioma: |
Inglês |
Conteúdo: |
Nano-engineered delivery systems have emerged as possible solutions for more efficient pest management in agriculture. Likewise for nanostructured drug delivery systems (DDS) in medicine, the use of biocide delivery systems (BDS) brought concerns on their toxicology on non-targeted organisms. Plants, for instance, are the foundation of the ecosystem, acting as primary actor in the food chain and is associated with the whole biodiversity, being strictly related to human health. This is a very important consideration to fully understand the benefits of using delivery systems for crop protection and production. Herein, a biocide delivery system was prepared by loading nanostructured, microscaled, biogenic silica particles with thymol, a known phytotoxicant. The resulting system contains 120 mg of thymol per gram of silica and displays slow release features. The Allium cepa bioassay was chosen to demonstrate how the toxicity and cellular damages induced by thymol can be significantly reduced through a slow, controlled, release strategy. The lower mobility of the reference particles associated with slow-delivery features reduced the toxicity and cellular damages caused by thymol in the plant genetic model. |
Palavras-Chave: |
Biocida; Liberação lenta; Phyto toxicity; Slow delivery; Timol. |
Thesagro: |
Allium Cepa; Genética. |
Thesaurus NAL: |
Biocides; Genetics; Pest management; Thymol. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
Marc: |
LEADER 02129naa a2200313 a 4500 001 2106145 005 2019-10-30 008 2019 bl uuuu u00u1 u #d 024 7 $a10.1016/j.jhazmat.2018.12.117$2DOI 100 1 $aMATTOS, B. D. 245 $aSlow delivery of biocide from nanostructured, microscaled, particles reduces its phytoxicity$ba model investigation.$h[electronic resource] 260 $c2019 520 $aNano-engineered delivery systems have emerged as possible solutions for more efficient pest management in agriculture. Likewise for nanostructured drug delivery systems (DDS) in medicine, the use of biocide delivery systems (BDS) brought concerns on their toxicology on non-targeted organisms. Plants, for instance, are the foundation of the ecosystem, acting as primary actor in the food chain and is associated with the whole biodiversity, being strictly related to human health. This is a very important consideration to fully understand the benefits of using delivery systems for crop protection and production. Herein, a biocide delivery system was prepared by loading nanostructured, microscaled, biogenic silica particles with thymol, a known phytotoxicant. The resulting system contains 120 mg of thymol per gram of silica and displays slow release features. The Allium cepa bioassay was chosen to demonstrate how the toxicity and cellular damages induced by thymol can be significantly reduced through a slow, controlled, release strategy. The lower mobility of the reference particles associated with slow-delivery features reduced the toxicity and cellular damages caused by thymol in the plant genetic model. 650 $aBiocides 650 $aGenetics 650 $aPest management 650 $aThymol 650 $aAllium Cepa 650 $aGenética 653 $aBiocida 653 $aLiberação lenta 653 $aPhyto toxicity 653 $aSlow delivery 653 $aTimol 700 1 $aSILVA, L. R. da 700 1 $aSOUZA, I. R. de 700 1 $aMAGALHAES, W. L. E. 700 1 $aLEME, D. M. 773 $tJournal of Hazardous Materials$gv. 367, p. 513-519, Apr. 2019. 7 p.
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