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Registro Completo |
Biblioteca(s): |
Embrapa Gado de Leite. |
Data corrente: |
10/05/2022 |
Data da última atualização: |
10/05/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
QUINTAO, C. C. R.; CAMARGO, L. S. de A.; BRANDAO, H. de M.; SARAIVA, N. Z.; MUNK, M. |
Afiliação: |
CAROLINA CAPOBIANGO ROMANO QUINTAO, CNPGL; LUIZ SERGIO DE ALMEIDA CAMARGO, CNPGL; HUMBERTO DE MELLO BRANDAO, CNPGL; NAIARA ZOCCAL SARAIVA, CNPGL; MICHELE MUNK, Universidade Federal de Juiz de Fora. |
Título: |
Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
Einstein, v. 20, eRB5898, 2022. |
DOI: |
https://doi.org/10.31744/einstein_journal/2022RB5898 |
Idioma: |
Inglês |
Conteúdo: |
The delivery of nucleic acids to cells is considered a crucial step for the success of genetic modifications aimed at therapeutic purposes or production of genetically modified animals. In this context, nanotechnology is one of the most promising fields of science, with the potential to solve several existing problems. Nanostructures have desirable characteristics to be used as carriers, such as nanometric size, large surface area, cell internalization capacity, prolonged and controlled release, among others. Genetically modified animals can contribute to the production of biopharmaceuticals, through the expression of high-associated-value molecules. The production of these animals, also known as biofactories, further enhances Brazilian agribusiness, since it allows adding value to the final product, and favors the integration between the agricultural market and the pharmaceutical sector. However, there is a growing concern about the safety and possible harmful effects of nanostructures, since data on the safe use of these materials are still insufficient. The objective of this review was to address aspects of the use of nanostructures, mainly carbon nanotubes as nucleic acid carriers, aiming at the production of genetically modified animals, with the certainty that progress in this field of knowledge depends on more information on the mechanisms of interaction between nanostructures, cells and embryos, as well as on its toxicity. |
Palavras-Chave: |
Genetically modified; Nanoestrutura; Nanotecnologia; Nanotubo de carbono. |
Thesagro: |
Ácido Nucléico; Genética Animal; Melhoramento Genético Animal. |
Thesaurus Nal: |
Embryonic structures; Nanotubes; Nucleic acids. |
Categoria do assunto: |
G Melhoramento Genético |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1142832/1/Challenges-use-nanostructures.pdf
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Marc: |
LEADER 02366naa a2200301 a 4500 001 2142832 005 2022-05-10 008 2022 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.31744/einstein_journal/2022RB5898$2DOI 100 1 $aQUINTAO, C. C. R. 245 $aChallenges in the use of nanostructures as carriers of nucleic acids in clinical practice.$h[electronic resource] 260 $c2022 520 $aThe delivery of nucleic acids to cells is considered a crucial step for the success of genetic modifications aimed at therapeutic purposes or production of genetically modified animals. In this context, nanotechnology is one of the most promising fields of science, with the potential to solve several existing problems. Nanostructures have desirable characteristics to be used as carriers, such as nanometric size, large surface area, cell internalization capacity, prolonged and controlled release, among others. Genetically modified animals can contribute to the production of biopharmaceuticals, through the expression of high-associated-value molecules. The production of these animals, also known as biofactories, further enhances Brazilian agribusiness, since it allows adding value to the final product, and favors the integration between the agricultural market and the pharmaceutical sector. However, there is a growing concern about the safety and possible harmful effects of nanostructures, since data on the safe use of these materials are still insufficient. The objective of this review was to address aspects of the use of nanostructures, mainly carbon nanotubes as nucleic acid carriers, aiming at the production of genetically modified animals, with the certainty that progress in this field of knowledge depends on more information on the mechanisms of interaction between nanostructures, cells and embryos, as well as on its toxicity. 650 $aEmbryonic structures 650 $aNanotubes 650 $aNucleic acids 650 $aÁcido Nucléico 650 $aGenética Animal 650 $aMelhoramento Genético Animal 653 $aGenetically modified 653 $aNanoestrutura 653 $aNanotecnologia 653 $aNanotubo de carbono 700 1 $aCAMARGO, L. S. de A. 700 1 $aBRANDAO, H. de M. 700 1 $aSARAIVA, N. Z. 700 1 $aMUNK, M. 773 $tEinstein$gv. 20, eRB5898, 2022.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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![](/consulta/web/img/deny.png) | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Corte. Para informações adicionais entre em contato com cnpgc.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Gado de Corte. |
Data corrente: |
09/03/2006 |
Data da última atualização: |
30/10/2007 |
Autoria: |
SAKAGUTI, E. S.; MARTINS, E. N.; SILVA, L. O. C. da. |
Título: |
Parâmetros genéticos dos parâmetros da curva de crescimento estimados a partir de dados de peso corporal reais e simulados de bovinos Tabapuã jovens. |
Ano de publicação: |
2004 |
Fonte/Imprenta: |
In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 41., 2004, Campo Grande, MS. A produção animal e a segurança alimentar: anais dos simpósios e dos resumos. Campo Grande, MS: Sociedade Brasileira de Zootecnia: Embrapa Gado de Corte, 2004. |
Páginas: |
5 p. MELH 048. |
Descrição Física: |
1 CD-ROM. |
Idioma: |
Português |
Notas: |
CNPGC. |
Palavras-Chave: |
Bovino de corte; Efeito materno; Genetic parameters; Growing; Herdabilidade; Simulation; Tabapuã. |
Thesagro: |
Crescimento; Melhoramento Genético Animal; Parâmetro Genético; Peso; Simulação. |
Thesaurus NAL: |
animal breeding; beef cattle; heritability; maternal effect; weight. |
Categoria do assunto: |
-- |
Marc: |
LEADER 01250naa a2200361 a 4500 001 1325992 005 2007-10-30 008 2004 bl uuuu u00u1 u #d 100 1 $aSAKAGUTI, E. S. 245 $aParâmetros genéticos dos parâmetros da curva de crescimento estimados a partir de dados de peso corporal reais e simulados de bovinos Tabapuã jovens. 260 $c2004 300 $a5 p. MELH 048.$c1 CD-ROM. 500 $aCNPGC. 650 $aanimal breeding 650 $abeef cattle 650 $aheritability 650 $amaternal effect 650 $aweight 650 $aCrescimento 650 $aMelhoramento Genético Animal 650 $aParâmetro Genético 650 $aPeso 650 $aSimulação 653 $aBovino de corte 653 $aEfeito materno 653 $aGenetic parameters 653 $aGrowing 653 $aHerdabilidade 653 $aSimulation 653 $aTabapuã 700 1 $aMARTINS, E. N. 700 1 $aSILVA, L. O. C. da 773 $tIn: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 41., 2004, Campo Grande, MS. A produção animal e a segurança alimentar: anais dos simpósios e dos resumos. Campo Grande, MS: Sociedade Brasileira de Zootecnia: Embrapa Gado de Corte, 2004.
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