| |
|
|
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
|
Data corrente: |
28/01/2015 |
|
Data da última atualização: |
23/09/2019 |
|
Tipo da produção científica: |
Nota Técnica/Nota Científica |
|
Autoria: |
BRESSANI, F. A.; TIZIOTO, P. C.; GIGLIOTI, R.; MEIRELLHES, S. L. C.; COUTINHO, L. L.; BENVENUTI, C. L.; MALAGO JUNIOR, W.; MUDADU, M. de A.; VIEIRA, L. da S.; ZAROS, L. G.; CARRILHO, E.; REGITANO, L. C. de A. |
|
Afiliação: |
FLAVIA ALINE BRESSANI DONATONI, CPPSE; Pós-graduação - Universidade Federal de São Carlos (UFSCAR) - São Carlos, SP, Brasil; Universidade Estadual Paulista (Unesp) - Jaboticabal, SP, Brasil; Universidade Federal de Lavras, Lavras, MG, Brasil.; Universidade Federal do Rio Grande do Norte (UFRN) - Natal, RN, Brasil; UFRN - Natal, RN, Brasil; WILSON MALAGO JUNIOR, CPPSE; MAURICIO DE ALVARENGA MUDADU, CPPSE; LUIZ DA SILVA VIEIRA, CNPC; UFRN - Natal, RN, Brasil; Universidade de São Paulo - São Carlos, SP, Brasil.; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
|
Título: |
Single nucleotide polymorphisms in candidate genes associated with gastrointestinal nematode infection in goats. |
|
Ano de publicação: |
2014 |
|
Fonte/Imprenta: |
Genetics and Molecular Research, v. 13, n. 4, p. 8530-8436, Oct. 2014. |
|
DOI: |
10.4238/2014.October.20.29 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Abstract: Cytokines are small cell-signaling proteins that play an important role in the immune system, participating in intracellular communication. Four candidate genes of the cytokine family (IL2, IL4, IL13, and IFNG) were selected to identify Single Nucleotide Polymorphisms (SNPs) that might be associated with resistance to gastrointestinal endoparasites in goats. A population of 229 goats, F2 offspring from an F1 intercross was produced by crossing pure Saanen goats, considered as susceptible to gastrointestinal endoparasites, with pure Anglo-Nubian goats, considered resistant. Blood was collected for DNA extraction and fecal samples were also collected for parasite egg count. Polymorphisms were prospected by sequencing animals with extreme phenotype for fecal egg count (FEC) distribution. The association between SNPs and phenotype was determined by using the Fisher exact test with correction for multiple tests. Three of the 10 SNPs were identified as significant (P ? 0.03). They were found in intron 1 of IL2 (ENSBTA00000020883), intron 3 of IL13 (ENSBTA00000015953) and exon 3 of IFNG (ENSBTA00000012529), suggesting an association between them and gastrointestinal endoparasite resistance. Further studies will help describe the effects of these markers accurately before implementing them in marker assisted selection. This study is the pioneer in describing such associations in goats. |
|
Palavras-Chave: |
Candidate gene; Citocina; Gastrointestinal diseases; Nematode; Nematódeo gastrintestinal; Resistance. |
|
Thesagro: |
Caprino; Helminto gastrintestinal; Infecção; Marcador genetico; Nematóide; Resistência. |
|
Thesaurus Nal: |
Cytokines; Genetic markers; Goats; Infection; Nematode infections; single nucleotide polymorphism. |
|
Categoria do assunto: |
G Melhoramento Genético |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/113908/1/PROCI-2014.00127.pdf
|
|
Marc: |
LEADER 02811naa a2200481 a 4500
001 2006912
005 2019-09-23
008 2014 bl uuuu u00u1 u #d
024 7 $a10.4238/2014.October.20.29$2DOI
100 1 $aBRESSANI, F. A.
245 $aSingle nucleotide polymorphisms in candidate genes associated with gastrointestinal nematode infection in goats.$h[electronic resource]
260 $c2014
520 $aAbstract: Cytokines are small cell-signaling proteins that play an important role in the immune system, participating in intracellular communication. Four candidate genes of the cytokine family (IL2, IL4, IL13, and IFNG) were selected to identify Single Nucleotide Polymorphisms (SNPs) that might be associated with resistance to gastrointestinal endoparasites in goats. A population of 229 goats, F2 offspring from an F1 intercross was produced by crossing pure Saanen goats, considered as susceptible to gastrointestinal endoparasites, with pure Anglo-Nubian goats, considered resistant. Blood was collected for DNA extraction and fecal samples were also collected for parasite egg count. Polymorphisms were prospected by sequencing animals with extreme phenotype for fecal egg count (FEC) distribution. The association between SNPs and phenotype was determined by using the Fisher exact test with correction for multiple tests. Three of the 10 SNPs were identified as significant (P ? 0.03). They were found in intron 1 of IL2 (ENSBTA00000020883), intron 3 of IL13 (ENSBTA00000015953) and exon 3 of IFNG (ENSBTA00000012529), suggesting an association between them and gastrointestinal endoparasite resistance. Further studies will help describe the effects of these markers accurately before implementing them in marker assisted selection. This study is the pioneer in describing such associations in goats.
650 $aCytokines
650 $aGenetic markers
650 $aGoats
650 $aInfection
650 $aNematode infections
650 $asingle nucleotide polymorphism
650 $aCaprino
650 $aHelminto gastrintestinal
650 $aInfecção
650 $aMarcador genetico
650 $aNematóide
650 $aResistência
653 $aCandidate gene
653 $aCitocina
653 $aGastrointestinal diseases
653 $aNematode
653 $aNematódeo gastrintestinal
653 $aResistance
700 1 $aTIZIOTO, P. C.
700 1 $aGIGLIOTI, R.
700 1 $aMEIRELLHES, S. L. C.
700 1 $aCOUTINHO, L. L.
700 1 $aBENVENUTI, C. L.
700 1 $aMALAGO JUNIOR, W.
700 1 $aMUDADU, M. de A.
700 1 $aVIEIRA, L. da S.
700 1 $aZAROS, L. G.
700 1 $aCARRILHO, E.
700 1 $aREGITANO, L. C. de A.
773 $tGenetics and Molecular Research$gv. 13, n. 4, p. 8530-8436, Oct. 2014.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 4 | |
| 1. |  | SANTOS, O. O. dos; MISTURA, C.; ARAUJO, G. G. L. de; PEREIRA, L. G. R.; PORTO, E. R.; ARAÚJO, J. R. de; SILVA, J. R. R. Composição mineral de silagens de erva-sal com diferentes proporções de capim- elefante. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 46., 2009, Maringá. Inovação científica e tecnológica em zootecnia: anais dos resumos. Maringa: SBZ: UEM, 2009. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Semiárido. |
|    |
| 2. | | SILVA, J. R. R.; MISTURA, C.; ARAUJO, G. G. L. de; PORTO, E. R.; VOLTOLINI, T. V.; MOURA NETO, J. B. de; LOPES, R. S. Parâmetros estruturais da erva-sal cultivada em diferentes espaçamentos e irrigada com rejeito de dessalinizadores no semi-árido. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 46., 2009, Maringá. Inovação científica e tecnológica em zootecnia: anais dos resumos. Maringa: SBZ: UEM, 2009. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Semiárido. |
| |
| 3. | | CORDEIRO, Y. E. M.; PINHEIRO, H. A.; SANTOS FILHO, B. G. dos; CORREA, S. S.; SILVA, J. R. R. e; DIAS-FILHO, M. B. Physiological and morphological responses of young mahogany (Swietenia macrophylla King) plants to drought. Forest Ecology and Management, v. 258, n. 7, p. 1449-1455, Sep. 2009.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Amazônia Oriental. |
|  |
| 4. | | SILVA, J. R. R.; MISTURA C.; ARAUJO, G. G. L. de; PORTO, E. R.; VOLTOLINI, T. V.; OLIVEIRA, P. T. L. de; SANTOS, O. O. dos. Produção de erva-sal cultivada em diferentes espaçamentos e irrigada com rejeito de dessalinizadores no semi-árido. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 46., 2009, Maringá. Inovação científica e tecnológica em zootecnia: anais dos resumos. Maringa: SBZ: UEM, 2009. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Semiárido. |
| |
| Registros recuperados : 4 | |
|
| Expressão de busca inválida. Verifique!!! |
|
|
