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| Registros recuperados : 6 | |
| 2. |  | SILVA, B. C. R.; BERNARDO, M. P.; MATTOSO, L. H. C. Avaliação físico-química de [Mg-Al]-HDL carregado com naproxeno sódico pelo método de reconstrução estrutural. In: JORNADA CIENTÍFICA - EMBRAPA SÃO CARLOS, 11., 2019, São Carlos, SP. Anais... São Carlos: Embrapa Pecuária Sudeste: Embrapa Instrumentação, 2019. Editores técnicos: Alexandre Berndt, Ana Rita de Araujo Nogueira, Lea Chapaval, Marcelo Mattos Cavallari, Manuel Antonio Chagas Jacinto. 46 Embrapa Pecuária Sudeste. Documentos, 134.| Biblioteca(s): Embrapa Instrumentação. |
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| 3. | | SILVA, B. C. R.; BERNARDO, M. P.; MOREIRA, F. K. V.; MATTOSO, L. H. C. Avaliação de propriedades físico-químicas de compósitos bioativos baseados em poli (ácido lático) e hidroxiapatita para impressão 3D. In: SIMPÓSIO NACIONAL DE INSTRUMENTAÇÃO AGROPECUÁRIA, 4., 2019, São Carlos, SP. Ciência, inovação e mercado: anais. São Carlos, SP: Embrapa Instrumentação, 2019. Editores: Paulino Ribeiro Villas-Boas, Maria Alice Martins, Débora Marcondes Bastos Pereira Milori, Ladislau Martin Neto. SIAGRO 2019. 642-645| Biblioteca(s): Embrapa Instrumentação. |
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| 5. | | SILVA, B. C. R.; BERNARDO, M. P.; MATTOSO, L. H. C. Propriedades térmicas de filamentos compósitos baseados em poli (ácido lático) e hidroxiapatita para prototipagem rápida. In: JORNADA CIENTÍFICA - EMBRAPA SÃO CARLOS, 12., 2020, São Carlos, SP. Anais... São Carlos: Embrapa Instrumentação: Embrapa Pecuária Sudeste, 2020. Editores técnicos: Cristiane Sanchez Farinas, Daniel Souza Corrêa, José Manoel Marconcini, Maria Fernanda Berlingieri Durigan, Paulo Sérgio de Paula Herrmann Junior. 41 Embrapa Instrumentação. Documentos, 71.| Biblioteca(s): Embrapa Instrumentação. |
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| 6. | | BULHOES, J. S.; ASSIS, A. O.; MARTINS, C. L.; FURRIEL, G. P.; SILVA, B. C. R.; RODRIGUES, L.; REIS, M. R. C.; CALHEIROS, D. F.; OLIVEIRA, M. D. de; CALIXTO, W. P. Gap filling in time series: A new methodology applying spectral analysis and system identification. In: CONFERENCE ON ELECTRICAL, ELECTRONICS ENGINEERING, INFORMATION AND COMMUNICATION TECHNOLOGIES. 2017, Pucon, Chile. [Proceedings...]. Pucon, Chile: IEE Xplore, 2017. Não paginado. (CHILECON).| Biblioteca(s): Embrapa Pantanal. |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
21/09/2021 |
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Data da última atualização: |
10/06/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
BERNARDO, M. P.; SILVA, B. C. R. da; MATTOSO, L. H. C. |
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Afiliação: |
LUIZ HENRIQUE CAPPARELLI MATTOSO, CNPDIA. |
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Título: |
Development of three-dimensional printing filaments based on poly(lactic acid)/hydroxyapatite composites with potential for tissue engineering. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Journal of Composite Materials, v. 55, n. 17, 2021. |
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Páginas: |
2289 - 2300 |
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ISSN: |
0021-9983 |
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DOI: |
10.1177/0021998320988568 |
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Idioma: |
Inglês |
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Conteúdo: |
Injured bone tissues can be healed with scaffolds, which could be manufactured using the fused deposition modeling (FDM) strategy. Poly(lactic acid) (PLA) is one of the most biocompatible polymers suitable for FDM, while hydroxyapatite (HA) could improve the bioactivity of scaffold due to its chemical composition. Therefore, the combination of PLA/HA can create composite filaments adequate for FDM and with high osteoconductive and osteointegration potentials. In this work, we proposed a different approache to improve the potential bioactivity of 3D printed scaffolds for bone tissue engineering by increasing the HA loading (20-30%) in the PLA composite filaments. Two routes were investigated regarding the use of solvents in the filament production. To assess the suitability of the FDM-3D printing process, and the influence of the HA content on the polymer matrix, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were performed. The HA phase content of the composite filaments agreed with the initial composite proportions. The wettability of the 3D printed scaffolds was also increased. It was shown a greener route for obtaining composite filaments that generate scaffolds with properties similar to those obtained by the solvent casting, with high HA content and great potential to be used as a bone graft. |
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Palavras-Chave: |
Bone reconstruction; Green alternative; Solvent-free route. |
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Categoria do assunto: |
-- |
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Marc: |
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001 2134648
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022 $a0021-9983
024 7 $a10.1177/0021998320988568$2DOI
100 1 $aBERNARDO, M. P.
245 $aDevelopment of three-dimensional printing filaments based on poly(lactic acid)/hydroxyapatite composites with potential for tissue engineering.$h[electronic resource]
260 $c2021
300 $a2289 - 2300
520 $aInjured bone tissues can be healed with scaffolds, which could be manufactured using the fused deposition modeling (FDM) strategy. Poly(lactic acid) (PLA) is one of the most biocompatible polymers suitable for FDM, while hydroxyapatite (HA) could improve the bioactivity of scaffold due to its chemical composition. Therefore, the combination of PLA/HA can create composite filaments adequate for FDM and with high osteoconductive and osteointegration potentials. In this work, we proposed a different approache to improve the potential bioactivity of 3D printed scaffolds for bone tissue engineering by increasing the HA loading (20-30%) in the PLA composite filaments. Two routes were investigated regarding the use of solvents in the filament production. To assess the suitability of the FDM-3D printing process, and the influence of the HA content on the polymer matrix, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were performed. The HA phase content of the composite filaments agreed with the initial composite proportions. The wettability of the 3D printed scaffolds was also increased. It was shown a greener route for obtaining composite filaments that generate scaffolds with properties similar to those obtained by the solvent casting, with high HA content and great potential to be used as a bone graft.
653 $aBone reconstruction
653 $aGreen alternative
653 $aSolvent-free route
700 1 $aSILVA, B. C. R. da
700 1 $aMATTOSO, L. H. C.
773 $tJournal of Composite Materials$gv. 55, n. 17, 2021.
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