Data/hora: 23/09/2024 18:56:50

Biblioteca(s): 	Embrapa Suínos e Aves.	
Data corrente: 	30/10/2019	
Data da última atualização: 	30/10/2019	
Autoria: 	MARCHESI, J. A. P.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; PANDOLFI, J. R. C.; MARCIANO, C. M. M.; ZANELLA, R.; SETTLES, M. L.; COUTINHO, L. L.; LEDUR, M. C.	
Afiliação: 	JORGE AUGUSTO PETROLI MARCHESI, USP; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; JOSE RODRIGO CLAUDIO PANDOLFI, CNPSA; CAROLINE M. MARINHO MARCIANO, UDESC/Chapecó; RICARDO ZANELLA, UPF; MATTHEW LEE SETTLES, University of California; LUIZ LEHMMAN COUTINHO, USP; MONICA CORREA LEDUR, CNPSA.	
Título: 	Whole transcriptome analysis of the pectoralis major muscle reveals molecular mechanisms involved with white striping in broiler chickens.	
Ano de publicação: 	2019	
Fonte/Imprenta: 	Poultry Science, v. 98, n. 2, p. 590-601, 2019.	
DOI: 	10.3382/ps/pey429	
Idioma: 	Inglês	
Conteúdo: 	Abstract: White striping (WS) is one of the most common myopathies identified in broiler chickens leading to substantial production losses, where the incidence reaches 12% in commercial chickens. It occurs primarily in heavier chickens being a modification of the breast muscle characterized by the presence of pale parallel streaks in the same orientation of the muscle fibers. Since the WS etiology remains unclear, we aimed to identify the biological and genetic mechanisms involved in its occurrence through the whole transcriptome analysis of WS in affected and unaffected chicken breast muscles. A total of 11,177 genes were expressed in the pectoralis major muscle. Out of those, 1,441genes were differentially expressed (FDR ? 0.01) between the two analyzed groups, being, respectively, 772 genes upregulated and 669 downregulated in the WS affected group. A total of 36 significantly overrepresented GO terms related to WS myopathy were enriched, and the most relevant biological processes were activation of immune system, angiogenesis, hypoxia, cell death, and striated muscle contraction. The unbalance of those biological processes may trigger the occurrence of the WS phenotype in broilers. The possible lack of capillary blood supply homogeneously in the muscle triggers the hypoxia, following the activation of glycolysis, calcium signaling and apoptosis related genes facilitating the tissue damage and WS incidence.	
Palavras-Chave: 	Breast myopathy; Muscle disorder; RNA-Seq.	
Thesagro: 	Frango de Corte; Genética Animal; Genética Molecular.	
Thesaurus Nal: 	Animal genetics; Broiler chickens; Sequence analysis.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Suínos e Aves (CNPSA)	
Exemplares: 	CNPSA - (21659-1) - UPC - AP - DD -  -  -  - DIS