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| 1. |  | SERIBELLI, A. A.; SILVA, P. da; FRAZÃO, M. R.; KICH, J. D.; ALLARD, M. W.; FALCÃO, J. P. Phylogenetic relationship and genomic characterization of Salmonella Typhimurium strains isolated from swine in Brazil. Infection, Genetics and Evolution, v. 92, n. 104977, 2021.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 2. | | SERIBELLI, A. A.; FRAZÃO, M. R.; GONZALES, J. C.; CAO, G.; LEON, M. S.; KICH, J. D.; ALLARD, M. W.; FALCÃO, J. P. Draft Genome Sequences of 20 Salmonella enterica subsp. enterica Serovar Typhimurium Strains Isolated from Swine in Santa Catarina, Brazil. Genome Announcements, v. 6, issue 16, e00232-18, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 3. | | SERIBELLI, A. A.; SILVA, P. da; CRUZ, M. F. da; ALMEIDA, F. de; FRAZÃO, M. R.; MEDEIROS, M. I. C.; RODRIGUES, D. dos P.; KICH, J. D.; BENEVIDES, L. de J.; SOARES, S. de C.; ALLARD, M. W.; FALCÃO, J. P. Insights about the epidemiology of Salmonella typhimurium isolates from different sources in Brazil using comparative genomics. Gut Pathogens, v. 13, n. 27, 2021.| Biblioteca(s): Embrapa Suínos e Aves. |
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| Registros recuperados : 3 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Suínos e Aves. Para informações adicionais entre em contato com cnpsa.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
31/08/2021 |
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Data da última atualização: |
31/08/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SERIBELLI, A. A.; SILVA, P. da; FRAZÃO, M. R.; KICH, J. D.; ALLARD, M. W.; FALCÃO, J. P. |
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Afiliação: |
AMANDA APARECIDA SERIBELLI, USP; PATRICK DA SILVA, UNESP; MILIANE RODRIGUES FRAZÃO, USP; JALUSA DEON KICH, CNPSA; MARC W. ALLARD, Food and Drug Administration; JULIANA PFRIMER FALCÃO, USP. |
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Título: |
Phylogenetic relationship and genomic characterization of Salmonella Typhimurium strains isolated from swine in Brazil. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Infection, Genetics and Evolution, v. 92, n. 104977, 2021. |
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DOI: |
https://doi.org/10.1016/j.meegid.2021.104977 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Salmonella Typhimurium has been transmitted between humans and animals. Although, Brazil has been one of the largest pork meat exporters worldwide, there are few studies that characterized epidemiologically S. Typhimurium strains from swine. The aims of this work were to study the phylogenetic relationship of S. Typhimurium genomes isolated from swine in Brazil among themselves and with other genomes isolated from several sources and countries using wgMLST and cgMLST and to perform the search of Salmonella pathogenicity islands (SPIs). In addition, for S. Typhimurium strains from swine to compare the virulence and antimicrobial resistance genes by VFDB and ResFinder, genetic content by BLAST Atlas and orthologous proteins clusters by OrthoVenn. The constructed phylogenetic trees by wgMLST and cgMLST grouped the majority (92.3% and 80.7%, respectively) of the strains isolated from swine in Brazil into the same group. All the isolates contained important SPIs (SPI-1, SPI-2, SPI-3, SPI-5 and SPI-9). A total of 100 and 31 virulence and resistance genes were detected in the S. Typhimurium strains isolated from swine, respectively. The BLAST Atlas and orthologous proteins analysis found regions of phages and differences in metabolic, regulatory and cellular processes among S. Typhimurium LT2 and S. Typhimurium isolates from swine. In conclusion, molecular typing based in the wgMLST and cgMLST suggested that the S. Typhimurium isolates from swine studied were genetically related. The pathogenic potential of the strains studied was corroborated by the presence of important SPIs and virulence genes. The high number of antimicrobial resistance genes detected is worrying and reinforced their potential risk in swine in Brazil. The comparison by BLAST Atlas suggested differences in mobile genetic elements among S. Typhimurium LT2 and S. Typhimurium isolates from swine in Brazil. The orthologous proteins analysis revealed unique genes related to important cellular processes in the strains from swine. MenosAbstract: Salmonella Typhimurium has been transmitted between humans and animals. Although, Brazil has been one of the largest pork meat exporters worldwide, there are few studies that characterized epidemiologically S. Typhimurium strains from swine. The aims of this work were to study the phylogenetic relationship of S. Typhimurium genomes isolated from swine in Brazil among themselves and with other genomes isolated from several sources and countries using wgMLST and cgMLST and to perform the search of Salmonella pathogenicity islands (SPIs). In addition, for S. Typhimurium strains from swine to compare the virulence and antimicrobial resistance genes by VFDB and ResFinder, genetic content by BLAST Atlas and orthologous proteins clusters by OrthoVenn. The constructed phylogenetic trees by wgMLST and cgMLST grouped the majority (92.3% and 80.7%, respectively) of the strains isolated from swine in Brazil into the same group. All the isolates contained important SPIs (SPI-1, SPI-2, SPI-3, SPI-5 and SPI-9). A total of 100 and 31 virulence and resistance genes were detected in the S. Typhimurium strains isolated from swine, respectively. The BLAST Atlas and orthologous proteins analysis found regions of phages and differences in metabolic, regulatory and cellular processes among S. Typhimurium LT2 and S. Typhimurium isolates from swine. In conclusion, molecular typing based in the wgMLST and cgMLST suggested that the S. Typhimurium isolates from swine studied were genetically ... Mostrar Tudo |
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Palavras-Chave: |
Análises filogenéticas; BLAST Atlas; Genes de virulência e resistência; Orthologous proteins; Phylogenetic analyses; Proteínas ortólogas; Relação filogenética; SPIs; Virulence and resistance genes. |
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Thesagro: |
Salmonella Typhimurium; Suíno. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03077naa a2200325 a 4500
001 2133959
005 2021-08-31
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.meegid.2021.104977$2DOI
100 1 $aSERIBELLI, A. A.
245 $aPhylogenetic relationship and genomic characterization of Salmonella Typhimurium strains isolated from swine in Brazil.$h[electronic resource]
260 $c2021
520 $aAbstract: Salmonella Typhimurium has been transmitted between humans and animals. Although, Brazil has been one of the largest pork meat exporters worldwide, there are few studies that characterized epidemiologically S. Typhimurium strains from swine. The aims of this work were to study the phylogenetic relationship of S. Typhimurium genomes isolated from swine in Brazil among themselves and with other genomes isolated from several sources and countries using wgMLST and cgMLST and to perform the search of Salmonella pathogenicity islands (SPIs). In addition, for S. Typhimurium strains from swine to compare the virulence and antimicrobial resistance genes by VFDB and ResFinder, genetic content by BLAST Atlas and orthologous proteins clusters by OrthoVenn. The constructed phylogenetic trees by wgMLST and cgMLST grouped the majority (92.3% and 80.7%, respectively) of the strains isolated from swine in Brazil into the same group. All the isolates contained important SPIs (SPI-1, SPI-2, SPI-3, SPI-5 and SPI-9). A total of 100 and 31 virulence and resistance genes were detected in the S. Typhimurium strains isolated from swine, respectively. The BLAST Atlas and orthologous proteins analysis found regions of phages and differences in metabolic, regulatory and cellular processes among S. Typhimurium LT2 and S. Typhimurium isolates from swine. In conclusion, molecular typing based in the wgMLST and cgMLST suggested that the S. Typhimurium isolates from swine studied were genetically related. The pathogenic potential of the strains studied was corroborated by the presence of important SPIs and virulence genes. The high number of antimicrobial resistance genes detected is worrying and reinforced their potential risk in swine in Brazil. The comparison by BLAST Atlas suggested differences in mobile genetic elements among S. Typhimurium LT2 and S. Typhimurium isolates from swine in Brazil. The orthologous proteins analysis revealed unique genes related to important cellular processes in the strains from swine.
650 $aSalmonella Typhimurium
650 $aSuíno
653 $aAnálises filogenéticas
653 $aBLAST Atlas
653 $aGenes de virulência e resistência
653 $aOrthologous proteins
653 $aPhylogenetic analyses
653 $aProteínas ortólogas
653 $aRelação filogenética
653 $aSPIs
653 $aVirulence and resistance genes
700 1 $aSILVA, P. da
700 1 $aFRAZÃO, M. R.
700 1 $aKICH, J. D.
700 1 $aALLARD, M. W.
700 1 $aFALCÃO, J. P.
773 $tInfection, Genetics and Evolution$gv. 92, n. 104977, 2021.
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