Data/hora: 16/06/2024 10:42:32

Biblioteca(s): | Embrapa Amazônia Ocidental.
Data corrente: | 19/09/2022
Data da última atualização: | 04/11/2022
Autoria: | O'SULLIVAN, F. L. A.; SKAFTNESMO, K. O.; ANDERSSON, E.; KLEPPE, L.; EDVARDSEN, R. B.; NORBERG, B.; FJELLDAL, P. G.; HANSEN, T. J.; SCHULZ, R. W.; WARGELIUS, A.
Afiliação: | FERNANDA LOUREIRO ALMEIDA OSULLIVAN, CPAA; K. O. SKAFTNESMO, Institute of Marine Research; E. ANDERSSON, Institute of Marine Research; L. KLEPPE, Institute of Marine Research; R. B. EDVARDSEN, Institute of Marine Research; B. NORBERG, Institute of Marine Research; P. G. FJELLDAL, Institute of Marine Research; T. J. HANSEN, Institute of Marine Research; R. W. SCHULZ, Institute of Marine Research; A. WARGELIUS, Institute of Marine Research.
Título: | The Piwil1 N domain is required for germ cell survival in Atlantic salmon.
Ano de publicação: | 2022
Fonte/Imprenta: | Frontiers in Cell and Developmental Biology, v. 10, art. 977779, 2022.
Idioma: | Inglês
Conteúdo: | Genetic introgression of farmed salmon into wild populations can damage the genetic integrity of wild stocks and is therefore considered as an environmental threat. One possible solution is to induce sterility in farmed salmon. We have searched for proteins potentially essential for germline survival in Atlantic salmon. One of these is the argonaute protein Piwil1, known to be required for germ cell survival. To examine Piwil1 function in salmon, we induced indels in the N domain by CRISPR-Cas9. The encoded domain is present in all vertebrate Piwi proteins and has been linked to Tdrd1 protein interaction and PAZ lobe structure.
Palavras-Chave: | Argonaute protein; Fish sterility; Germline.
Thesaurus Nal: | Spermatogenesis.
Categoria do assunto: | --
Registro original: | Embrapa Amazônia Ocidental (CPAA)
Exemplares: | CPAA - (38822-1) - UPC - AP - DD -  -  -  - DIS