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| Registros recuperados : 33 | |
| 10. |  | BRÂNCIO, P. A.; EUCLIDES, V. P. B.; NASCIMENTO JÚNIOR, D. do; REGAZZI, A. J.; ALMEIDA, R. G.; FONSECA, D. M. Consumo de matéria seca e ganho de peso por bovinos em pastejo na avaliação de cultivares de Panicum maximum Jacq. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 38., 2001, Piracicaba. Anais... Piracicaba: FEALQ, 2001. p. 224-225. CNPGC. SBZ.| Biblioteca(s): Embrapa Gado de Corte. |
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| 13. | | BRANCIO, P. A.; NASCIMENTO JUNIOR, D. do; MORAES, E. A. de; REGAZZI, A. J.; LEITE, G. G. Qualidade da dieta de bovinos em pastagem nativa dos cerrados submetida a queima anual. In: REUNIAO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 33., 1996, Fortaleza, CE. Anais... Fortaleza: SBZ, 1996. v.2. p.227-229.| Biblioteca(s): Embrapa Cerrados. |
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| 14. | | BRANCIO, P. A.; NASCIMENTO JUNIOR, D. do; REGAZZI, A. J.; MORAES, E. A. de; LEITE, G. G. Avaliacao de pastagem nativa dos cerrados submetida a queima anual. 1. Composicao botanica da dieta de bovinos. Revista Brasileira de Zootecnia, Vicosa, v.26, n.3, p.429-437, 1997.| Biblioteca(s): Embrapa Cerrados. |
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| 15. | | BRANCIO, P. A.; NASCIMENTO JUNIOR, D. do; MORAES, E. A. de; REGAZZI, A. J.; LEITE, G. G. Avaliacao de pastagem nativa dos cerrados submetida a queima anual. 2. Qualidade da dieta de bovinos. Revista Brasileira de Zootecnia, Vicosa, v.26, n.3, p.438-442, 1997.| Biblioteca(s): Embrapa Cerrados. |
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| 16. | | BRÂNCIO, P. A.; NASCIMENTO JÚNIOR, D. do; EUCLIDES, V. P. B.; REGAZZI, A. J.; ALMEIDA, R. G.; FONSECA, D. M. Valor nutritivo da forragem disponível e da dieta selecionada por bovinos em pastagens de cultivares de Panicum maximum Jacq. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 38., 2001, Piracicaba. Anais... Piracicaba: FEALQ, 2001. P. 222-223. CNPGC. SBZ.| Biblioteca(s): Embrapa Gado de Corte. |
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| 17. | | ALMEIDA, R. G. de; NASCIMENTO JÚNIOR, D. do; EUCLIDES, V. P. B.; MACEDO, M. C. M.; FONECA, D. M. da; BRÂNCIO, P. A.; GARCEZ NETO, A. F. Disponibilidade, composição botânica e valor nutritivo da forragem de pastos consorciados, sob três taxas de lotação. Revista Brasileira de Zootecnia, v. 32, n. 1. p. 36-46, fev.. 2003.| Biblioteca(s): Embrapa Gado de Corte. |
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| 18. | | ALMEIDA, R. G. de; EUCLIDES, V. P. B.; NASCIMENTO JUNIOR, D. do; MACEDO, M. C. M.; REGAZZI, A. J.; BRANCIO, P. A.; FONSECA, P. M. Pastagens consorciadas de braquiarias com estilosantes, no cerrado. 2. Consumo, composicao botanica e valor nutritivo da dieta. In: REUNIAO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 38., 2001, Piracicaba. Anais... Piracicaba: FEALQ, 2001. p.64-65.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 19. | | ALMEIDA, R. G. de; NASCIMENTO JÚNIOR, D. do; EUCLIDES, V. P. B.; MACEDO, M. C. M.; REGAZZI, A. J.; BRÂNCIO, P. A.; FONSECA, D. M. da. Pastagens consorciadas de braquiárias com estilosanthes, no cerrado 1.Disponibilidade de forragem, composição botânica e valor nutritivo. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 38., 2001, Piracicaba. Anais... Piracicaba: FEALQ, 2001. p. 60-61. CNPGC. SBZ.| Biblioteca(s): Embrapa Gado de Corte. |
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| 20. | | ALMEIDA, R. G. de; EUCLIDES, V. P. B.; NASCIMENTO JÚNIOR, D. do; MACEDO, M. C. M.; REGAZZI, A. J.; BRÂNCIO, P. A.; FONSECA, D. M. da. Pastagens consorciadas de braquiárias com estilosanthes, no cerrado 2. Consumo, composição botânica e valor nutrivo da dieta. In: REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE ZOOTECNIA, 38., 2001, Piracicaba. Anais... Piracicaba: FEALQ, 2001. p. 64-65. CNPGC. SBZ.| Biblioteca(s): Embrapa Gado de Corte. |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Instrumentação. |
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Data corrente: |
20/04/2023 |
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Data da última atualização: |
18/07/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 3 |
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Autoria: |
PEREA, G. N. R.; PAVINATTO, A.; SCHNEIDER, R.; MUNK, M.; BRANDAO, H. de M.; CORREA, D. S. |
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Afiliação: |
Universidade de São Paulo; Universidade Federal de São Carlos; Universidade Federal de Juiz de Fora; HUMBERTO DE MELLO BRANDAO, CNPGL; DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Electrospun nanofibers based on polyvinylpyrrolidone/chitosan and cloxacillin: investigation of morphological features, antibiotic release and antimicrobial properties. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Journal of Polymer Research, v. 30, 166, 2023. |
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DOI: |
https://doi.org/10.1007/s10965-023-03535-7 |
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Idioma: |
Inglês |
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Conteúdo: |
Polymer nanofbers possess a range of attractive features that make them highly suitable for various biomedical application, including their high surface area/volume ratio, mechanical fexibility, porosity and potential for surface or bulk functionalization. Besides, such nanofbers can be used to encapsulate antibiotics to fabricate slow-release systems, but in this case the nanofbers should be fabricated with biocompatible and biodegradable polymers. Here we developed a novel nanocarrier system based on polyvinylpyrrolidone (PVP)/chitosan (CHI) electrospun nanofbers containing cloxacillin benzathine (CLO). PVP was chosen because of its ability to form nanofbers, while a small amount of chitosan was added to help control the CLO release, which antibiotic is widely employed to treat bacterial infections. The as-produced CLO-containing electrospun nanofbers were characterized regarding their morphological features and antibiotic release profle. SEM images revealed homogeneous and defectsfree nanofbers, exhibiting no discernible morphological variations between the CLO-containing and CLO-non-containing nanofbers. FTIR results indicate hydrogen bonds formation between carboxyl and carboxylate groups from CLO and hydroxyl groups from CHI. The antimicrobial properties of antibiotic-loaded nanofbers were investigated against Gram-positive bacteria S. aureus, yielding inhibition zone diameters of 12.5±1.6 mm and 29.8±1.3 mm for PVP/CHI/CLO and PVP/CLO nanofbers, respectively. Besides, the drug release kinetics study indicates that the nanocarrier system formed by PVP/CHI can release the antibiotics more slowly due to the chemical interactions between CHI and CLO compounds. Our results suggest that drug activity was preserved after encapsulation by electrospinning, and the diference in the inhibition zone diameter was corroborated by drug release mechanism experiments, indicating the system as a potential material to treat infections caused by S. aureus MenosPolymer nanofbers possess a range of attractive features that make them highly suitable for various biomedical application, including their high surface area/volume ratio, mechanical fexibility, porosity and potential for surface or bulk functionalization. Besides, such nanofbers can be used to encapsulate antibiotics to fabricate slow-release systems, but in this case the nanofbers should be fabricated with biocompatible and biodegradable polymers. Here we developed a novel nanocarrier system based on polyvinylpyrrolidone (PVP)/chitosan (CHI) electrospun nanofbers containing cloxacillin benzathine (CLO). PVP was chosen because of its ability to form nanofbers, while a small amount of chitosan was added to help control the CLO release, which antibiotic is widely employed to treat bacterial infections. The as-produced CLO-containing electrospun nanofbers were characterized regarding their morphological features and antibiotic release profle. SEM images revealed homogeneous and defectsfree nanofbers, exhibiting no discernible morphological variations between the CLO-containing and CLO-non-containing nanofbers. FTIR results indicate hydrogen bonds formation between carboxyl and carboxylate groups from CLO and hydroxyl groups from CHI. The antimicrobial properties of antibiotic-loaded nanofbers were investigated against Gram-positive bacteria S. aureus, yielding inhibition zone diameters of 12.5±1.6 mm and 29.8±1.3 mm for PVP/CHI/CLO and PVP/CLO nanofbers, respectively. Besides,... Mostrar Tudo |
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Palavras-Chave: |
Antibiotic release; Electrospinning; Eletrofiação; Mastite; Slow-release. |
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Thesagro: |
Antibiótico; Bovino; Doença Animal; Tratamento. |
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Categoria do assunto: |
--
L Ciência Animal e Produtos de Origem Animal |
|
Marc: |
LEADER 02915naa a2200301 a 4500
001 2153293
005 2023-07-18
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s10965-023-03535-7$2DOI
100 1 $aPEREA, G. N. R.
245 $aElectrospun nanofibers based on polyvinylpyrrolidone/chitosan and cloxacillin$binvestigation of morphological features, antibiotic release and antimicrobial properties.$h[electronic resource]
260 $c2023
520 $aPolymer nanofbers possess a range of attractive features that make them highly suitable for various biomedical application, including their high surface area/volume ratio, mechanical fexibility, porosity and potential for surface or bulk functionalization. Besides, such nanofbers can be used to encapsulate antibiotics to fabricate slow-release systems, but in this case the nanofbers should be fabricated with biocompatible and biodegradable polymers. Here we developed a novel nanocarrier system based on polyvinylpyrrolidone (PVP)/chitosan (CHI) electrospun nanofbers containing cloxacillin benzathine (CLO). PVP was chosen because of its ability to form nanofbers, while a small amount of chitosan was added to help control the CLO release, which antibiotic is widely employed to treat bacterial infections. The as-produced CLO-containing electrospun nanofbers were characterized regarding their morphological features and antibiotic release profle. SEM images revealed homogeneous and defectsfree nanofbers, exhibiting no discernible morphological variations between the CLO-containing and CLO-non-containing nanofbers. FTIR results indicate hydrogen bonds formation between carboxyl and carboxylate groups from CLO and hydroxyl groups from CHI. The antimicrobial properties of antibiotic-loaded nanofbers were investigated against Gram-positive bacteria S. aureus, yielding inhibition zone diameters of 12.5±1.6 mm and 29.8±1.3 mm for PVP/CHI/CLO and PVP/CLO nanofbers, respectively. Besides, the drug release kinetics study indicates that the nanocarrier system formed by PVP/CHI can release the antibiotics more slowly due to the chemical interactions between CHI and CLO compounds. Our results suggest that drug activity was preserved after encapsulation by electrospinning, and the diference in the inhibition zone diameter was corroborated by drug release mechanism experiments, indicating the system as a potential material to treat infections caused by S. aureus
650 $aAntibiótico
650 $aBovino
650 $aDoença Animal
650 $aTratamento
653 $aAntibiotic release
653 $aElectrospinning
653 $aEletrofiação
653 $aMastite
653 $aSlow-release
700 1 $aPAVINATTO, A.
700 1 $aSCHNEIDER, R.
700 1 $aMUNK, M.
700 1 $aBRANDAO, H. de M.
700 1 $aCORREA, D. S.
773 $tJournal of Polymer Research$gv. 30, 166, 2023.
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