| |
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria Tropical. Para informações adicionais entre em contato com cnpat.biblioteca@embrapa.br. |
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Agroindústria Tropical. |
|
Data corrente: |
14/05/2025 |
|
Data da última atualização: |
14/05/2025 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
COUTINHO, T. DO N. P.; RODRIGUES, F. A. M.; ASSIS, D. A. DE; REBOUÇAS, L. M.; FERREIRA, T. L.; CABRAL, V. P. DE F.; RODRIGUES, D. S.; SÁ, L. G. DO A. V.; LOPES, F. F. DA S.; NASCIMENTO, G. A DO; MATTOS, A. L. A.; CAVALCANTI, B. C.; NOBRE JÚNIOR, H. V.; SILVA, C. R. DA; RICARDO, N. M. P. S. |
|
Afiliação: |
TATIANA DO N. P. COUTINHO, FEDERAL UNIVERSITY OF CEARÁ; FRANCISCO A. M. RODRIGUES, FEDERAL UNIVERSITY OF CEARÁ; DAVID A. DE ASSIS, FEDERAL UNIVERSITY OF CEARÁ; LOUHANA M. REBOUÇAS, FEDERAL UNIVERSITY OF CEARÁ; THAIS L. FERREIRA, FEDERAL UNIVERSITY OF CEARÁ; VITÓRIA P. DE F. CABRAL, FEDERAL UNIVERSITY OF CEARÁ; DANIEL S. RODRIGUES, FEDERAL UNIVERSITY OF CEARÁ; LÍVIA G. DO A. V. SÁ, FEDERAL UNIVERSITY OF CEARÁ; FRANCISCO F. DA S. LOPES, CEARÁ STATE UNIVERSITY; GABRIELA A. DO NASCIMENTO, STATE UNIVERSITY OF CEARÁ; ADRIANO LINCOLN ALBUQUERQUE MATTOS, CNPAT; BRUNO C. CAVALCANTI, FEDERAL UNIVERSITY OF CEARÁ; HÉLIO V. NOBRE JÚNIOR, FEDERAL UNIVERSITY OF CEARÁ; CECÍLIA R. DA SILVA, FEDERAL UNIVERSITY OF CEARÁ; NÁGILA M. P. S. RICARDO, FEDERAL UNIVERSITY OF CEARÁ. |
|
Título: |
Microspheres based on galactomannan and Spondias purpurea L. extract to increase antifungal and antibiofilm efficacy against Candida spp. |
|
Ano de publicação: |
2025 |
|
Fonte/Imprenta: |
International Journal of Biological Macromolecules, 297, 139788, 2025. |
|
DOI: |
https://doi.org/10.1016/j.ijbiomac.2025.139788 |
|
Idioma: |
Inglês |
|
Conteúdo: |
The ongoing problem of an increasing resistance of Candida spp. to available antifungals, has made it necessary the search for new therapeutic alternatives. The aim of this work was to develop a microsphere based on Caesalpinia ferrea galactomannan and Spondias purpurea L. stem bark extract using the spray drying technique and evaluate its antimicrobial effect on biofilm formation and planktonic cells of Candida spp. Differential scanning calorimetry (DSC), infrared analysis (IR) and scanning electron microscopy (SEM) were used to characterize the microsphere, in addition to the encapsulation efficiency by HPLC to quantify the extract in the microsphere. In microbiological analyses, broth microdilution and antibiofilm tests were carried out. The results of the minimum inhibitory concentration (MIC) for the stem bark extract (SBE) were within 0.5 – 2 μ g mL 1 and the galactomannan microsphere (GMB) 1 – 8 μ g mL 1. As for the biofilm, the microsphere compared to the extract showed a statistically significant improvement at 8xMIC for C. albicans 1, while for C. auris, it was at 4xMIC and 8xMIC. Furthermore, SBE and GMB did not present toxicity. The study revealed that the synthesized microspheres have the potential to be used as an antifungal agent. |
|
Palavras-Chave: |
Antifungal; Antifúngico; Galactomanana; Microesferas; Microspheres. |
|
Thesagro: |
Biofilme; Caesalpinia Férrea; Spondias Purpurea. |
|
Thesaurus Nal: |
Biofilm; Galactomannans. |
|
Categoria do assunto: |
-- |
|
Marc: |
LEADER 02578naa a2200421 a 4500
001 2175605
005 2025-05-14
008 2025 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.ijbiomac.2025.139788$2DOI
100 1 $aCOUTINHO, T. DO N. P.
245 $aMicrospheres based on galactomannan and Spondias purpurea L. extract to increase antifungal and antibiofilm efficacy against Candida spp.$h[electronic resource]
260 $c2025
520 $aThe ongoing problem of an increasing resistance of Candida spp. to available antifungals, has made it necessary the search for new therapeutic alternatives. The aim of this work was to develop a microsphere based on Caesalpinia ferrea galactomannan and Spondias purpurea L. stem bark extract using the spray drying technique and evaluate its antimicrobial effect on biofilm formation and planktonic cells of Candida spp. Differential scanning calorimetry (DSC), infrared analysis (IR) and scanning electron microscopy (SEM) were used to characterize the microsphere, in addition to the encapsulation efficiency by HPLC to quantify the extract in the microsphere. In microbiological analyses, broth microdilution and antibiofilm tests were carried out. The results of the minimum inhibitory concentration (MIC) for the stem bark extract (SBE) were within 0.5 – 2 μ g mL 1 and the galactomannan microsphere (GMB) 1 – 8 μ g mL 1. As for the biofilm, the microsphere compared to the extract showed a statistically significant improvement at 8xMIC for C. albicans 1, while for C. auris, it was at 4xMIC and 8xMIC. Furthermore, SBE and GMB did not present toxicity. The study revealed that the synthesized microspheres have the potential to be used as an antifungal agent.
650 $aBiofilm
650 $aGalactomannans
650 $aBiofilme
650 $aCaesalpinia Férrea
650 $aSpondias Purpurea
653 $aAntifungal
653 $aAntifúngico
653 $aGalactomanana
653 $aMicroesferas
653 $aMicrospheres
700 1 $aRODRIGUES, F. A. M.
700 1 $aASSIS, D. A. DE
700 1 $aREBOUÇAS, L. M.
700 1 $aFERREIRA, T. L.
700 1 $aCABRAL, V. P. DE F.
700 1 $aRODRIGUES, D. S.
700 1 $aSÁ, L. G. DO A. V.
700 1 $aLOPES, F. F. DA S.
700 1 $aNASCIMENTO, G. A DO
700 1 $aMATTOS, A. L. A.
700 1 $aCAVALCANTI, B. C.
700 1 $aNOBRE JÚNIOR, H. V.
700 1 $aSILVA, C. R. DA
700 1 $aRICARDO, N. M. P. S.
773 $tInternational Journal of Biological Macromolecules, 297, 139788, 2025.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Agroindústria Tropical (CNPAT) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 3 | |
| 3. |  | MIDORIKAWA, G. E. O.; SANTOS, L. C. Z.; OLIVEIRA, P. A. de; FAVARO, L. C. de L. Prospecção, seleção e identificação de bactérias produtoras de corantes. In: ENCONTRO DE PESQUISA E INOVAÇÃO DA EMBRAPA AGROENERGIA, 6., 2020, Brasília, DF. Anais... Brasília, DF: Embrapa, 2020. p. 195-200 il.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroenergia. |
|    |
| Registros recuperados : 3 | |
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
