Data/hora: 24/09/2024 09:38:37

Biblioteca(s): 	Embrapa Pecuária Sudeste.	
Data corrente: 	16/12/2014	
Data da última atualização: 	28/03/2023	
Autoria: 	ALEXANDRE, P. A.; GOMES, R. da C.; SANTANA, M. H. A.; SILVA, S. L.; LEMES, P. R.; MUDADU, M. de A.; REGITANO, L. C. de A.; MEIRELLES, F. V.; FERRAZ, J. B. S.; FUKUMASU, H.	
Afiliação: 	PÂMELA A. ALEXANDRE, UNIVERSIDADE DE SÃO PAULO/PIRASSUNUNGA; RODRIGO DA COSTA GOMES, CNPGC; MIGUEL H. A. SANTANA, USP/PIRASSUNUNGA; SAULO L. SILVA, UNIVERSIDADE DE SAO PAULO/PIRASSUNUNGA; PAULO R. LEMES, UNIVERSIDADE DE SÃO PAULO/PIRASSUNUNGA; MAURICIO DE ALVARENGA MUDADU, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; FLAVIO V. MEIRELLES, UNIVERSIDADE DE SAO PAULO/PIRASSUNUNGA; JOSÉ B. S. FERRAZ, UNIVERSIDADE DE SAO PAULO/PIRASSUNUNGA; HEIDGE FUKUMASU, UNIVERSIDADE DE SAO PAULO/PIRASSUNUNGA.	
Título: 	Bovine NR1I3 gene polymorphisms and its association with feed efficiency traits in Nellore cattle.	
Ano de publicação: 	2014	
Fonte/Imprenta: 	Meta Gene, v. 2, p. 206-217, dec. 2014.	
DOI: 	10.1016/j.mgene.2014.01.003	
Idioma: 	Inglês	
Conteúdo: 	The Nuclear receptor 1 family I member 3 (NR1I3), also known as the Constitutive Androstane Receptor (CAR), was initially characterized as a key regulator of xenobiotic metabolism. However, recent biochemical and structural data suggest that NR1I3 is activated in response to metabolic and nutritional stress in a ligand-independent manner. Thus, we prospected the Bovine NR1I3 gene for polymorphisms and studied their association with feed efficiency traits in Nellore cattle. First, 155 purebredNellore bullswere individuallymeasured for Residual Feed Intake (RFI) and the 25 best (High Feed Efficiency group, HFE) and the 25 worst animals (Low Feed Efficiency group, LFE) were selected for DNA extraction. The entire Bovine NR1I3 gene was amplified and polymorphisms were identified by sequencing. Then, one SNP different between HFE and LFE groupswas genotyped in all the 155 animals and in another 288 animals totalizing 443 Nellore bulls genotyped for association of NR1I3 SNPs with feed efficiency traits. We found 24 SNPs in the NR1I3 gene and choose a statistically different SNP between HFE and LFE groups for further analysis. Genotyping of the 155 animals showed a significant associationwithin SNP and RFI (p = 0.04), Residual Intake and BW Gain (p = 0.04) and Dry Matter Intake (p = 0.01). This SNP is located in the 5&#8242;flanking promoter region of NR1I3.	
Palavras-Chave: 	CAR; NR113 gene; Residual feed intake.	
Thesaurus Nal: 	beef cattle; Nellore.	
Categoria do assunto: 	G Melhoramento Genético	
Registro original: 	Embrapa Pecuária Sudeste (CPPSE)	
Exemplares: 	CPPSE - (22720-1) - UPC - AP - DD - PROCI-2014.00126 - ALE - 2014.00126 - DIS